Parathyroid hormone (1-34) augments spinal fusion, fusion mass volume, and fusion mass quality in a rabbit spinal fusion model.

O'Loughlin PF, Cunningham ME, Bukata SV, Tomin E, Poynton AR, Doty SB, Sama AA, Lane JM

Spine1 Jan 2009Cited by 78 (Europe PMC)

PMID19112335DOI10.1097/brs.0b013e318191e687PepBankPUB-19112335

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rabbits after spinal fusion surgery, PTH increased fusion frequency to 81% versus 30% with saline.
In plain wordsIn rabbits after spinal fusion surgery, PTH increased fusion frequency compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFusion by manual bending
Study
New Zealand white rabbitsn = 44
Posterolateral spinal fusion
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 microg/kg daily · subcutaneous · 6 weeksAs given in this study (New Zealand white rabbits).
Source sentences
Summary
Manual bending identified fusion in 30% (control) versus 81% (PTH) animals (P < 0.001).
3 context sentences(design, population, supporting numbers)
Summary · context
Forty-four male New Zealand white rabbits underwent bilateral posterolateral spine fusion (L5-L6 level).
Summary · context
Twenty-two rabbits received daily subcutaneous injections of PTH (1-34) (10 microg/kg) and 22 received an injection of saline fluid.
Summary · context
All were killed 6 weeks after surgery.
Report a problemFND-1911233501
02AnimalAnimal study (in vivo)Efficacy outcome
In rabbits after spinal fusion surgery, PTH increased the average radiographic score to 4.51 versus 3.36 with saline.
In plain wordsIn rabbits after spinal fusion surgery, PTH increased the radiographic fusion score compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseRadiographic fusion score
Study
New Zealand white rabbitsn = 44
Posterolateral spinal fusion
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 microg/kg daily · subcutaneous · 6 weeksAs given in this study (New Zealand white rabbits).
Source sentences
Summary
A radiographic scoring system ("0" = no bone formation, "5" = full fusion) resulted in an average score of 3.36 (control) versus 4.51 (PTH) (P < 0.001).
3 context sentences(design, population, supporting numbers)
Summary · context
Forty-four male New Zealand white rabbits underwent bilateral posterolateral spine fusion (L5-L6 level).
Summary · context
Twenty-two rabbits received daily subcutaneous injections of PTH (1-34) (10 microg/kg) and 22 received an injection of saline fluid.
Summary · context
All were killed 6 weeks after surgery.
Report a problemFND-1911233502
03AnimalAnimal study (in vivo)Efficacy outcome
In rabbits after spinal fusion surgery, PTH increased median fusion mass volume to 6.03 cc versus 3.5 cc with saline.
In plain wordsIn rabbits after spinal fusion surgery, PTH increased fusion mass volume compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFusion mass volume
Study
New Zealand white rabbitsn = 44
Posterolateral spinal fusion
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 microg/kg daily · subcutaneous · 6 weeksAs given in this study (New Zealand white rabbits).
Source sentences
Summary
MicroCT analysis demonstrated a median mass of 3.5 cc (control) (range, 2.25-5.40 cc) versus 6.03 cc (PTH) (range, 4.34-10.58 cc) (P < 0.001).
3 context sentences(design, population, supporting numbers)
Summary · context
Forty-four male New Zealand white rabbits underwent bilateral posterolateral spine fusion (L5-L6 level).
Summary · context
Twenty-two rabbits received daily subcutaneous injections of PTH (1-34) (10 microg/kg) and 22 received an injection of saline fluid.
Summary · context
All were killed 6 weeks after surgery.
Report a problemFND-1911233503
04AnimalAnimal study (in vivo)Efficacy outcome
In rabbits after spinal fusion surgery, PTH increased median bone area to 29.9% versus 14.3% with saline.
In plain wordsIn rabbits after spinal fusion surgery, PTH increased the bone area percentage compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone area percentage
Study
New Zealand white rabbitsn = 27
Posterolateral spinal fusion
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 microg/kg daily · subcutaneous · 6 weeksAs given in this study (New Zealand white rabbits).
Source sentences
Summary
Histology showed a median percentage bone area of 14.3% (control) (n = 12) versus 29.9% (PTH) (n = 15) (P < 0.001).
3 context sentences(design, population, supporting numbers)
Summary · context
Forty-four male New Zealand white rabbits underwent bilateral posterolateral spine fusion (L5-L6 level).
Summary · context
Twenty-two rabbits received daily subcutaneous injections of PTH (1-34) (10 microg/kg) and 22 received an injection of saline fluid.
Summary · context
All were killed 6 weeks after surgery.
Report a problemFND-1911233504
05AnimalAnimal study (in vivo)Efficacy outcome
In rabbits after spinal fusion surgery, PTH increased median osteoclast quantity to 345.0 versus 140.5 with saline.
In plain wordsIn rabbits after spinal fusion surgery, PTH increased osteoclast quantity compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseOsteoclast quantity
Study
New Zealand white rabbitsn = 14
Posterolateral spinal fusion
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 microg/kg daily · subcutaneous · 6 weeksAs given in this study (New Zealand white rabbits).
Source sentences
Summary
Osteoclast quantification revealed median values of 140.5 (control) (n = 6) and 345.0 (PTH) (n = 8) (P < 0.001) respectively,
3 context sentences(design, population, supporting numbers)
Summary · context
Forty-four male New Zealand white rabbits underwent bilateral posterolateral spine fusion (L5-L6 level).
Summary · context
Twenty-two rabbits received daily subcutaneous injections of PTH (1-34) (10 microg/kg) and 22 received an injection of saline fluid.
Summary · context
All were killed 6 weeks after surgery.
Report a problemFND-1911233506
06AnimalAnimal study (in vivo)Efficacy outcome
In rabbits after spinal fusion surgery, PTH increased median osteoblast percentage to 64.4% versus 31.4% with saline.
In plain wordsIn rabbits after spinal fusion surgery, PTH increased the osteoblast percentage compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseOsteoblast percentage
Study
New Zealand white rabbitsn = 14
Posterolateral spinal fusion
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 microg/kg daily · subcutaneous · 6 weeksAs given in this study (New Zealand white rabbits).
Source sentences
Summary
and the percentage of osteoblasts revealed a median value of 31.4% (control) (n = 6) versus 64.4% (PTH) (n = 8) (P < 0.001).
3 context sentences(design, population, supporting numbers)
Summary · context
Forty-four male New Zealand white rabbits underwent bilateral posterolateral spine fusion (L5-L6 level).
Summary · context
Twenty-two rabbits received daily subcutaneous injections of PTH (1-34) (10 microg/kg) and 22 received an injection of saline fluid.
Summary · context
All were killed 6 weeks after surgery.
Report a problemFND-1911233507
07AnimalAnimal study (in vivo)Efficacy outcome
In rabbits after spinal fusion surgery, PTH increased median cartilage percentage to 26.6% versus 2.7% with saline.
In plain wordsIn rabbits after spinal fusion surgery, PTH increased the cartilage percentage compared with saline.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCartilage percentage
Study
New Zealand white rabbitsn = 10
Posterolateral spinal fusion
Comparator
Saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 microg/kg daily · subcutaneous · 6 weeksAs given in this study (New Zealand white rabbits).
Source sentences
Summary
The median percentage cartilage was 2.7% (control) (n = 5) versus 26.6% (PTH) (n = 5) (P < 0.01).
3 context sentences(design, population, supporting numbers)
Summary · context
Forty-four male New Zealand white rabbits underwent bilateral posterolateral spine fusion (L5-L6 level).
Summary · context
Twenty-two rabbits received daily subcutaneous injections of PTH (1-34) (10 microg/kg) and 22 received an injection of saline fluid.
Summary · context
All were killed 6 weeks after surgery.
Report a problemFND-1911233505

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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