[Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study].

Narkevich VB, Kudrin VS, Klodt PM, Pokrovskiĭ AA, Kozlovskaia MM, Maĭskiĭ AI, Raevskiĭ KS

Eksperimental'naia i klinicheskaia farmakologiia1 Sept 2008Cited by 3 (Europe PMC)

PMID19093364PepBankPUB-19093364

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In BALB/C and C57Bl/6 mice, selank at 0.3 mg/kg increased norepinephrine in the hypothalamus in both strains.
In plain wordsIn two mouse strains, selank raised norepinephrine in the hypothalamus.
Peptide
Selank
Outcome
IncreaseNorepinephrine in hypothalamus
Study
mousen: not reported in source
BALB/C and C57Bl/6 mice
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
0.3 mg/kgAs given in this study (mouse).
Source sentences
Summary
The injection of selank (0.3 mg/kg) led to an increase in the NE level in the hypothalamus of both mice strains.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of heptapeptide selank on the content of neurotransmitter monoamines and its metabolites in the brain structures of BALB/C and C57Bl/6 line mice under conditions of the open-field test were studied.
Report a problemFND-1909336401
02AnimalAnimal study (in vivo)Mechanism
In C57Bl/6 mice, selank increased the dopamine metabolite DOPAC in the frontal cortex and hippocampus.
In plain wordsIn C57Bl/6 mice, selank raised a dopamine breakdown product in two brain regions.
Peptide
Selank
Outcome
IncreaseDOPAC in frontal cortex and hippocampus
Study
mousen: not reported in source
C57Bl/6 mice
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
At the same time, selank produced opposite effects on the content of DA metabolites: the concentrations of dioxyphenylacetic (DOPAC) and homovanillic (HVA) acids were found to increase in frontal cortex and hippocampus of C57Bl/6 mice, while the same parameters in BALB/C mice were demonstrated to decrease.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of heptapeptide selank on the content of neurotransmitter monoamines and its metabolites in the brain structures of BALB/C and C57Bl/6 line mice under conditions of the open-field test were studied.
Report a problemFND-1909336402
03AnimalAnimal study (in vivo)Mechanism
In C57Bl/6 mice, selank increased the dopamine metabolite homovanillic acid in the frontal cortex and hippocampus.
In plain wordsIn C57Bl/6 mice, selank raised a dopamine breakdown product in two brain regions.
Peptide
Selank
Outcome
IncreaseHVA in frontal cortex and hippocampus
Study
mousen: not reported in source
C57Bl/6 mice
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
At the same time, selank produced opposite effects on the content of DA metabolites: the concentrations of dioxyphenylacetic (DOPAC) and homovanillic (HVA) acids were found to increase in frontal cortex and hippocampus of C57Bl/6 mice, while the same parameters in BALB/C mice were demonstrated to decrease.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of heptapeptide selank on the content of neurotransmitter monoamines and its metabolites in the brain structures of BALB/C and C57Bl/6 line mice under conditions of the open-field test were studied.
Report a problemFND-1909336403
04AnimalAnimal study (in vivo)Mechanism
In BALB/C mice, selank decreased the dopamine metabolite DOPAC in the frontal cortex and hippocampus.
In plain wordsIn BALB/C mice, selank lowered a dopamine breakdown product in two brain regions.
Peptide
Selank
Outcome
DecreaseDOPAC in frontal cortex and hippocampus
Study
mousen: not reported in source
BALB/C mice
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
At the same time, selank produced opposite effects on the content of DA metabolites: the concentrations of dioxyphenylacetic (DOPAC) and homovanillic (HVA) acids were found to increase in frontal cortex and hippocampus of C57Bl/6 mice, while the same parameters in BALB/C mice were demonstrated to decrease.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of heptapeptide selank on the content of neurotransmitter monoamines and its metabolites in the brain structures of BALB/C and C57Bl/6 line mice under conditions of the open-field test were studied.
Report a problemFND-1909336404
05AnimalAnimal study (in vivo)Mechanism
In BALB/C mice, selank decreased the dopamine metabolite homovanillic acid in the frontal cortex and hippocampus.
In plain wordsIn BALB/C mice, selank lowered a dopamine breakdown product in two brain regions.
Peptide
Selank
Outcome
DecreaseHVA in frontal cortex and hippocampus
Study
mousen: not reported in source
BALB/C mice
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
At the same time, selank produced opposite effects on the content of DA metabolites: the concentrations of dioxyphenylacetic (DOPAC) and homovanillic (HVA) acids were found to increase in frontal cortex and hippocampus of C57Bl/6 mice, while the same parameters in BALB/C mice were demonstrated to decrease.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of heptapeptide selank on the content of neurotransmitter monoamines and its metabolites in the brain structures of BALB/C and C57Bl/6 line mice under conditions of the open-field test were studied.
Report a problemFND-1909336405
06AnimalAnimal study (in vivo)Mechanism
In BALB/C mice, selank decreased serotonin levels in the hippocampus.
In plain wordsIn BALB/C mice, selank lowered serotonin in the hippocampus.
Peptide
Selank
Outcome
DecreaseSerotonin in hippocampus
Study
mousen: not reported in source
BALB/C mice
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Selank induced a decrease in 5-HT and 5-HIAA levels in the hippocampus of BALB/C mice, but did not affect these parameters in C57Bl/6 animals.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of heptapeptide selank on the content of neurotransmitter monoamines and its metabolites in the brain structures of BALB/C and C57Bl/6 line mice under conditions of the open-field test were studied.
Report a problemFND-1909336406
07AnimalAnimal study (in vivo)Mechanism
In BALB/C mice, selank decreased the serotonin metabolite 5-HIAA in the hippocampus.
In plain wordsIn BALB/C mice, selank lowered a serotonin breakdown product in the hippocampus.
Peptide
Selank
Outcome
Decrease5-HIAA in hippocampus
Study
mousen: not reported in source
BALB/C mice
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Selank induced a decrease in 5-HT and 5-HIAA levels in the hippocampus of BALB/C mice, but did not affect these parameters in C57Bl/6 animals.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of heptapeptide selank on the content of neurotransmitter monoamines and its metabolites in the brain structures of BALB/C and C57Bl/6 line mice under conditions of the open-field test were studied.
Report a problemFND-1909336407
08AnimalAnimal study (in vivo)Mechanism
In C57Bl/6 mice, selank did not affect serotonin levels in the hippocampus.
In plain wordsIn C57Bl/6 mice, selank did not change serotonin in the hippocampus.
Peptide
Selank
Outcome
No significant changeSerotonin in hippocampus
Study
mousen: not reported in source
C57Bl/6 mice
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Selank induced a decrease in 5-HT and 5-HIAA levels in the hippocampus of BALB/C mice, but did not affect these parameters in C57Bl/6 animals.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of heptapeptide selank on the content of neurotransmitter monoamines and its metabolites in the brain structures of BALB/C and C57Bl/6 line mice under conditions of the open-field test were studied.
Report a problemFND-1909336408
09AnimalAnimal study (in vivo)Mechanism
In C57Bl/6 mice, selank did not affect the serotonin metabolite 5-HIAA in the hippocampus.
In plain wordsIn C57Bl/6 mice, selank did not change a serotonin breakdown product in the hippocampus.
Peptide
Selank
Outcome
No significant change5-HIAA in hippocampus
Study
mousen: not reported in source
C57Bl/6 mice
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Selank induced a decrease in 5-HT and 5-HIAA levels in the hippocampus of BALB/C mice, but did not affect these parameters in C57Bl/6 animals.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of heptapeptide selank on the content of neurotransmitter monoamines and its metabolites in the brain structures of BALB/C and C57Bl/6 line mice under conditions of the open-field test were studied.
Report a problemFND-1909336409

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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