Genotype-dependent characteristics of behavior in mice in cognitive tests. The effects of Noopept.

Bel'nik AP, Ostrovskaya RU, Poletaeva II

Neuroscience and behavioral physiology17 Dec 2008Cited by 2 (Europe PMC)

PMID19089630DOI10.1007/s11055-008-9095-1PepBankPUB-19089630

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In BALB/c mice, Noopept significantly improved long-term memory in the simplified Morris maze.
In plain wordsIn mice of the BALB/c strain, Noopept improved long-term memory.
Peptide
Noopept (omberacetam)
Outcome
IncreaseLong-term memory in BALB/c mice
Study
mousen: not reported in source
BALB/c mice
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
0.5 mg/kg · intraperitonealAs given in this study (mouse).
Source sentences
Summary
I.p. administration of the nootropic agent Noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) at a dose of 0.5 mg/kg 15 min before the start of the test induced significant improvements in long-term memory in this test in BALB/c mice but no further improvement in C57BL/6J mice, and had no…
1 context sentence(design, population, supporting numbers)
Summary · context
Male C57BL/6J, BALB/c, and DBA/2J mice showed differences in their abilities to perform two cognitive tests.
Report a problemFND-1908963001
02AnimalAnimal study (in vivo)Efficacy outcome
In C57BL/6J mice, Noopept produced no further improvement in long-term memory.
In plain wordsIn mice of the C57BL/6J strain, Noopept did not further improve long-term memory.
Peptide
Noopept (omberacetam)
Outcome
No significant changeLong-term memory in C57BL/6J mice
Study
mousen: not reported in source
C57BL/6J mice
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
0.5 mg/kg · intraperitonealAs given in this study (mouse).
Source sentences
Summary
I.p. administration of the nootropic agent Noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) at a dose of 0.5 mg/kg 15 min before the start of the test induced significant improvements in long-term memory in this test in BALB/c mice but no further improvement in C57BL/6J mice, and had no…
1 context sentence(design, population, supporting numbers)
Summary · context
Male C57BL/6J, BALB/c, and DBA/2J mice showed differences in their abilities to perform two cognitive tests.
Report a problemFND-1908963002
03AnimalAnimal study (in vivo)Efficacy outcome
In DBA/2J mice, Noopept had no effect in the simplified Morris maze.
In plain wordsIn mice of the DBA/2J strain, Noopept did not improve maze performance.
Peptide
Noopept (omberacetam)
Outcome
No significant changeMorris maze performance in DBA/2J mice
Study
mousen: not reported in source
DBA/2J mice
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
0.5 mg/kg · intraperitonealAs given in this study (mouse).
Source sentences
Summary
I.p. administration of the nootropic agent Noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) at a dose of 0.5 mg/kg 15 min before the start of the test induced significant improvements in long-term memory in this test in BALB/c mice but no further improvement in C57BL/6J mice, and had no…
1 context sentence(design, population, supporting numbers)
Summary · context
Male C57BL/6J, BALB/c, and DBA/2J mice showed differences in their abilities to perform two cognitive tests.
Report a problemFND-1908963003
04AnimalAnimal study (in vivo)Efficacy outcome
In C57BL/6J mice, Noopept increased correct responses when extrapolating stimulus movement.
In plain wordsIn mice of the C57BL/6J strain, Noopept increased correct predictions of stimulus movement.
Peptide
Noopept (omberacetam)
Outcome
IncreaseCorrect extrapolation responses in C57BL/6J mice
Study
mousen: not reported in source
C57BL/6J mice
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
0.5 mg/kg · intraperitonealAs given in this study (mouse).
Source sentences
Summary
On testing the ability to extrapolate the direction of movement of a stimulus, administration of Noopept increased the proportion of correct responses in C57BL/6J and BALB/c mice, but had no effect in DBA/2J mice.
2 context sentences(design, population, supporting numbers)
Summary · context
I.p. administration of the nootropic agent Noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) at a dose of 0.5 mg/kg 15 min before the start of the test induced significant improvements in long-term memory in this test in BALB/c mice but no further improvement in C57BL/6J mice, and had no…
Summary · context
Male C57BL/6J, BALB/c, and DBA/2J mice showed differences in their abilities to perform two cognitive tests.
Report a problemFND-1908963004
05AnimalAnimal study (in vivo)Efficacy outcome
In BALB/c mice, Noopept increased correct responses when extrapolating stimulus movement.
In plain wordsIn mice of the BALB/c strain, Noopept increased correct predictions of stimulus movement.
Peptide
Noopept (omberacetam)
Outcome
IncreaseCorrect extrapolation responses in BALB/c mice
Study
mousen: not reported in source
BALB/c mice
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
0.5 mg/kg · intraperitonealAs given in this study (mouse).
Source sentences
Summary
On testing the ability to extrapolate the direction of movement of a stimulus, administration of Noopept increased the proportion of correct responses in C57BL/6J and BALB/c mice, but had no effect in DBA/2J mice.
2 context sentences(design, population, supporting numbers)
Summary · context
I.p. administration of the nootropic agent Noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) at a dose of 0.5 mg/kg 15 min before the start of the test induced significant improvements in long-term memory in this test in BALB/c mice but no further improvement in C57BL/6J mice, and had no…
Summary · context
Male C57BL/6J, BALB/c, and DBA/2J mice showed differences in their abilities to perform two cognitive tests.
Report a problemFND-1908963005
06AnimalAnimal study (in vivo)Efficacy outcome
In DBA/2J mice, Noopept had no effect on extrapolation responses.
In plain wordsIn mice of the DBA/2J strain, Noopept did not change stimulus movement predictions.
Peptide
Noopept (omberacetam)
Outcome
No significant changeCorrect extrapolation responses in DBA/2J mice
Study
mousen: not reported in source
DBA/2J mice
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
0.5 mg/kg · intraperitonealAs given in this study (mouse).
Source sentences
Summary
On testing the ability to extrapolate the direction of movement of a stimulus, administration of Noopept increased the proportion of correct responses in C57BL/6J and BALB/c mice, but had no effect in DBA/2J mice.
2 context sentences(design, population, supporting numbers)
Summary · context
I.p. administration of the nootropic agent Noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) at a dose of 0.5 mg/kg 15 min before the start of the test induced significant improvements in long-term memory in this test in BALB/c mice but no further improvement in C57BL/6J mice, and had no…
Summary · context
Male C57BL/6J, BALB/c, and DBA/2J mice showed differences in their abilities to perform two cognitive tests.
Report a problemFND-1908963006

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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