Skip to content

Study · Not a test of the peptide alone · 2009

2 results

Aromatase and 5alpha-reductase inhibition during an exogenous testosterone clamp unveils selective sex steroid modulation of somatostatin and growth hormone secretagogue actions in healthy older men.

Veldhuis JD, Mielke KL, Cosma M, Soares-Welch C, Paulo R, Miles JM, Bowers CY

The Journal of clinical endocrinology and metabolism16 Dec 2008Cited by 39 (Europe PMC)

PMID19088159 (opens in a new tab)PMCIDPMC2681279 (opens in a new tab)DOI10.1210/jc.2008-2108 (opens in a new tab)PepBankPUB-19088159
Source linkPubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

  1. 01HumanNot a test of GHRP-2 aloneRandomized controlled trialMechanism

    In healthy older men, regression analysis showed that testosterone positively determined pulsatile GH secretion stimulated by GHRP‑2 (P < 0.001).

    In plain wordsIn healthy older men, higher testosterone was linked to a stronger GH pulse response when GHRP‑2 was infused.

    Peptide
    GHRP-2
    Outcome
    IncreaseTestosterone as determinant of GHRP-2-stimulated pulsatile GH secretion
    Study

    n = 42

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Te positively determines mean (P = 0.017) and peak (P < 0.001) GH concentrations, basal GH secretion (P = 0.015), and pulsatile GH secretion stimulated by GHRP-2 (P < 0.001)
    2 context sentences
    Summary · context
    SUBJECTS AND LOCATION: Healthy older men (N = 42, ages 50-79 yr) participated at an academic medical center.
    Summary · context
    We inhibited 5alpha-reduction with dutasteride and aromatization with anastrozole during a pharmacological Te clamp and infused somatostatin (SS), GHRH, GH-releasing peptide-2 (GHRP-2), and L-arginine/GHRH/GHRP-2 (triple stimulus) to modulate GH secretion.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  2. 02HumanNot a test of GHRP-2 aloneRandomized controlled trialMechanism

    In healthy older men, testosterone (positively) and estradiol (negatively) jointly predicted GH responses to the triple stimulus of L-arginine, GHRH and GHRP‑2.

    In plain wordsIn healthy older men, testosterone and estradiol together predicted the GH response to a three-part stimulus that included GHRP‑2.

    Peptide
    GHRP-2
    Outcome
    MixedTestosterone and estradiol as determinants of GH response to triple stimulus including GHRP-2
    Study

    n = 42

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Te and E(2) jointly predict GH responses to the triple stimulus (positively for Te, P = 0.006, and negatively for E(2), P = 0.031)
    2 context sentences
    Summary · context
    SUBJECTS AND LOCATION: Healthy older men (N = 42, ages 50-79 yr) participated at an academic medical center.
    Summary · context
    We inhibited 5alpha-reduction with dutasteride and aromatization with anastrozole during a pharmacological Te clamp and infused somatostatin (SS), GHRH, GH-releasing peptide-2 (GHRP-2), and L-arginine/GHRH/GHRP-2 (triple stimulus) to modulate GH secretion.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.