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Study · In vitro (cell-free) · 2007

2 results

ESI-MS study of the mechanism of glycyl-l-histidyl-l-lysine-Cu(II) complex transport through model membrane of stratum corneum.

Mazurowska L, Mojski M

Talanta22 Dec 2006Cited by 13 (Europe PMC)

PMID19071668 (opens in a new tab)DOI10.1016/j.talanta.2006.11.034 (opens in a new tab)PepBankPUB-19071668
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Other

    In a Flynn diffusion cell with a liposome membrane, only the tripeptide GHK and its copper complexes GHK‑Cu and (GHK)2-Cu migrated through the stratum corneum model membrane.

    In plain wordsIn lab tests, only GHK and its copper complexes passed through a membrane that models the outer skin layer.

    Peptide
    GHK-Cu
    Outcome
    Not applicableMembrane migration of GHK and its copper complexes
    Study

    n: not reported in source

    Flynn diffusion cell with liposome membrane
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was proved that only tripeptide GHK and its complexes with copper: GHK-Cu and (GHK)(2)-Cu are able to migrate through membrane model of stratum corneum.
    1 context sentence
    Summary · context
    The permeability phenomenon was studied by use in vitro model system-Flynn diffusion cell with the liposome membrane.
  2. 02LabIn vitro (cell-free)Other

    In a Flynn diffusion cell with a liposome membrane, the permeability coefficients of the copper complexes increased with increasing pH.

    In plain wordsIn lab tests, copper complexes passed through the model skin membrane faster as the pH of the solution rose.

    Peptide
    GHK-Cu
    Outcome
    IncreasePermeability coefficient of copper complexes versus pH
    Study

    n: not reported in source

    Flynn diffusion cell with liposome membrane
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The permeability coefficients of copper complexes increase with increasing pH.
    1 context sentence
    Summary · context
    The permeability phenomenon was studied by use in vitro model system-Flynn diffusion cell with the liposome membrane.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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