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Study · Animal study (in vivo) · sprague-dawley rats · 2009

7 results

Recombinant human parathyroid hormone (PTH 1-34) and low-intensity pulsed ultrasound have contrasting additive effects during fracture healing.

Warden SJ, Komatsu DE, Rydberg J, Bond JL, Hassett SM

Bone21 Nov 2008Cited by 54 (Europe PMC)

PMID19071238 (opens in a new tab)DOI10.1016/j.bone.2008.11.007 (opens in a new tab)PepBankPUB-19071238
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with femur fractures, PTH increased callus bone mineral content compared with vehicle.

    In plain wordsIn rats with femur fractures, PTH increased callus mineral content compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCallus bone mineral content
    Study

    Sprague-Dawley ratsn: not reported in source

    Bilateral midshaft femur fractures
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 7 days/weekAs given in this study (Sprague-Dawley rats).

    Source sentences

    Summary
    and PTH having the opposite effect of increasing BMC without influencing TV.
    3 context sentences
    Summary · context
    Bilateral midshaft femur fractures were created in Sprague-Dawley rats, and the animals treated 7 days/week with PTH (10 microg/kg) or a vehicle solution.
    Summary · context
    Each animal also had one fracture treated for 20 min/day with active-LIPUS (spatial-averaged, temporal-averaged intensity [I(SATA)]=100 mW/cm(2)) and the contralateral fracture treated with inactive-LIPUS (placebo).
    Summary · context
    Femurs were harvested 35 days following injury to permit micro-computed tomography, mechanical property and histological assessments of the fracture calluses.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with femur fractures, PTH did not influence total callus volume compared with vehicle.

    In plain wordsIn rats with femur fractures, PTH did not change callus volume compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeTotal callus volume
    Study

    Sprague-Dawley ratsn: not reported in source

    Bilateral midshaft femur fractures
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 7 days/weekAs given in this study (Sprague-Dawley rats).

    Source sentences

    Summary
    and PTH having the opposite effect of increasing BMC without influencing TV.
    3 context sentences
    Summary · context
    Bilateral midshaft femur fractures were created in Sprague-Dawley rats, and the animals treated 7 days/week with PTH (10 microg/kg) or a vehicle solution.
    Summary · context
    Each animal also had one fracture treated for 20 min/day with active-LIPUS (spatial-averaged, temporal-averaged intensity [I(SATA)]=100 mW/cm(2)) and the contralateral fracture treated with inactive-LIPUS (placebo).
    Summary · context
    Femurs were harvested 35 days following injury to permit micro-computed tomography, mechanical property and histological assessments of the fracture calluses.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with femur fractures, PTH increased callus volumetric bone mineral density compared with vehicle.

    In plain wordsIn rats with femur fractures, PTH increased callus bone density compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCallus volumetric bone mineral density
    Study

    Sprague-Dawley ratsn: not reported in source

    Bilateral midshaft femur fractures
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 7 days/weekAs given in this study (Sprague-Dawley rats).

    Source sentences

    Summary
    In contrast, the effect of PTH on callus BMC but not TV resulted in increased callus vBMD and a more mature callus.
    3 context sentences
    Summary · context
    Bilateral midshaft femur fractures were created in Sprague-Dawley rats, and the animals treated 7 days/week with PTH (10 microg/kg) or a vehicle solution.
    Summary · context
    Each animal also had one fracture treated for 20 min/day with active-LIPUS (spatial-averaged, temporal-averaged intensity [I(SATA)]=100 mW/cm(2)) and the contralateral fracture treated with inactive-LIPUS (placebo).
    Summary · context
    Femurs were harvested 35 days following injury to permit micro-computed tomography, mechanical property and histological assessments of the fracture calluses.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with femur fractures, PTH produced a more mature callus compared with vehicle.

    In plain wordsIn rats with femur fractures, PTH produced a more mature callus compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCallus maturity
    Study

    Sprague-Dawley ratsn: not reported in source

    Bilateral midshaft femur fractures
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 7 days/weekAs given in this study (Sprague-Dawley rats).

    Source sentences

    Summary
    In contrast, the effect of PTH on callus BMC but not TV resulted in increased callus vBMD and a more mature callus.
    3 context sentences
    Summary · context
    Bilateral midshaft femur fractures were created in Sprague-Dawley rats, and the animals treated 7 days/week with PTH (10 microg/kg) or a vehicle solution.
    Summary · context
    Each animal also had one fracture treated for 20 min/day with active-LIPUS (spatial-averaged, temporal-averaged intensity [I(SATA)]=100 mW/cm(2)) and the contralateral fracture treated with inactive-LIPUS (placebo).
    Summary · context
    Femurs were harvested 35 days following injury to permit micro-computed tomography, mechanical property and histological assessments of the fracture calluses.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with femur fractures, PTH increased fracture site mechanical strength compared with vehicle.

    In plain wordsIn rats with femur fractures, PTH increased fracture site strength compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseFracture site mechanical strength
    Study

    Sprague-Dawley ratsn: not reported in source

    Bilateral midshaft femur fractures
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 7 days/weekAs given in this study (Sprague-Dawley rats).

    Source sentences

    Summary
    This resulted in PTH increasing fracture site mechanical strength and stiffness.
    3 context sentences
    Summary · context
    Bilateral midshaft femur fractures were created in Sprague-Dawley rats, and the animals treated 7 days/week with PTH (10 microg/kg) or a vehicle solution.
    Summary · context
    Each animal also had one fracture treated for 20 min/day with active-LIPUS (spatial-averaged, temporal-averaged intensity [I(SATA)]=100 mW/cm(2)) and the contralateral fracture treated with inactive-LIPUS (placebo).
    Summary · context
    Femurs were harvested 35 days following injury to permit micro-computed tomography, mechanical property and histological assessments of the fracture calluses.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with femur fractures, PTH increased fracture site stiffness compared with vehicle.

    In plain wordsIn rats with femur fractures, PTH increased fracture site stiffness compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseFracture site stiffness
    Study

    Sprague-Dawley ratsn: not reported in source

    Bilateral midshaft femur fractures
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg, 7 days/weekAs given in this study (Sprague-Dawley rats).

    Source sentences

    Summary
    This resulted in PTH increasing fracture site mechanical strength and stiffness.
    3 context sentences
    Summary · context
    Bilateral midshaft femur fractures were created in Sprague-Dawley rats, and the animals treated 7 days/week with PTH (10 microg/kg) or a vehicle solution.
    Summary · context
    Each animal also had one fracture treated for 20 min/day with active-LIPUS (spatial-averaged, temporal-averaged intensity [I(SATA)]=100 mW/cm(2)) and the contralateral fracture treated with inactive-LIPUS (placebo).
    Summary · context
    Femurs were harvested 35 days following injury to permit micro-computed tomography, mechanical property and histological assessments of the fracture calluses.

Studies that did not test the peptide alone1

In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Teriparatide (PTH 1-34).

  1. 07AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Mechanism

    In rats with femur fractures, PTH and LIPUS showed no interaction, consistent with additive rather than synergistic effects.

    In plain wordsIn rats with femur fractures, PTH and ultrasound showed additive effects without evidence of synergy.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changePTH and LIPUS interaction
    Study

    Sprague-Dawley ratsn: not reported in source

    Bilateral midshaft femur fractures
    Comparator
    Individual PTH and LIPUS effects
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    There were no interactions between PTH and LIPUS indicating that their effects were additive rather than synergistic.
    3 context sentences
    Summary · context
    Bilateral midshaft femur fractures were created in Sprague-Dawley rats, and the animals treated 7 days/week with PTH (10 microg/kg) or a vehicle solution.
    Summary · context
    Each animal also had one fracture treated for 20 min/day with active-LIPUS (spatial-averaged, temporal-averaged intensity [I(SATA)]=100 mW/cm(2)) and the contralateral fracture treated with inactive-LIPUS (placebo).
    Summary · context
    Femurs were harvested 35 days following injury to permit micro-computed tomography, mechanical property and histological assessments of the fracture calluses.

    In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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