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Study · Not a test of the peptide alone · 2009

2 results

Electron capture dissociation of peptide hormone changes upon opening of the tocin ring and complexation with transition metal cations.

van der Burgt YE, Palmblad M, Dalebout H, Heeren RM, Deelder AM

Rapid communications in mass spectrometry : RCM1 Jan 2009Cited by 16 (Europe PMC)

PMID19051230 (opens in a new tab)DOI10.1002/rcm.3849 (opens in a new tab)PepBankPUB-19051230
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01LabNot a test of Oxytocin aloneIn vitro (cell-free)Other

    In electron capture dissociation mass spectrometry, opening the tocin ring of oxytocin changed the fragment type and the cleavage sites.

    In plain wordsIn lab tests, opening the ring structure of oxytocin changed how the molecule broke apart in a mass spectrometer.

    Peptide
    Oxytocin
    Outcome
    Not applicableECD fragment type and cleavage sites on opening the tocin ring
    Study

    n: not reported in source

    gas-phase mass spectrometry (ECD)
    Comparator
    Ring-opened analogue OT2
    Outcome group
    Peptide structure and chemistry · Pharmacology

    Source sentences

    Summary
    The ECD results showed that both the fragment type (c/z versus b/y) and the cleavage sites (ring versus tail) changed upon opening of the tocin ring.
    1 context sentence
    Summary · context
    In this work the ECD behavior of two peptide hormones oxytocin (OT1) and vasopressin (VP1) was studied.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02LabNot a test of Oxytocin aloneIn vitro (cell-free)Other

    In electron capture dissociation mass spectrometry, complexation of the peptides with Zn, Ni or Cu ions gave different cleavage sites within the same peptide.

    In plain wordsIn lab tests, binding different metal ions to the peptides changed where they broke apart in a mass spectrometer.

    Peptide
    Oxytocin
    Outcome
    Not applicableECD cleavage sites with transition metal complexation
    Study

    n: not reported in source

    gas-phase mass spectrometry (ECD)
    Outcome group
    Peptide structure and chemistry · Pharmacology

    Source sentences

    Summary
    The use of various metal ions yielded different cleavages sites within the same peptide.
    1 context sentence
    Summary · context
    In this work the ECD behavior of two peptide hormones oxytocin (OT1) and vasopressin (VP1) was studied.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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