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Study · Not a test of the peptide alone · 2009

4 results

Mechano-growth factor, an IGF-I splice variant, rescues motoneurons and improves muscle function in SOD1(G93A) mice.

Riddoch-Contreras J, Yang SY, Dick JR, Goldspink G, Orrell RW, Greensmith L

Experimental neurology7 Nov 2008Cited by 39 (Europe PMC)

PMID19038252 (opens in a new tab)DOI10.1016/j.expneurol.2008.10.014 (opens in a new tab)PepBankPUB-19038252
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

  1. 01AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome

    In SOD1(G93A) mice, intramuscular delivery of an MGF expression plasmid improved hindlimb muscle strength.

    In plain wordsIn mice with an ALS-like disease, a gene-delivery plasmid for MGF improved hind leg muscle strength.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseHindlimb muscle strength
    Study

    mousen: not reported in source

    SOD1(G93A) mouse model of ALS
    Outcome group
    Exercise and physical function · Nervous system and cognition

    Source sentences

    Summary
    Treatment with either IGF-I or MGF resulted in a significant improvement in hindlimb muscle strength
    1 context sentence
    Summary · context
    A mammalian expression plasmid containing either MGF or, for comparison, the IGF-I cDNA sequence was delivered to the hindlimb muscles of SOD1(G93A) mice at 70 days of age, at symptom onset.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  2. 02AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome

    In SOD1(G93A) mice, delivery of an MGF expression plasmid increased motor unit survival.

    In plain wordsIn mice with an ALS-like disease, a gene-delivery plasmid for MGF helped more motor units survive.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMotor unit survival
    Study

    mousen: not reported in source

    SOD1(G93A) mouse model of ALS
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    an increase in motor unit and motoneuron survival.
    1 context sentence
    Summary · context
    A mammalian expression plasmid containing either MGF or, for comparison, the IGF-I cDNA sequence was delivered to the hindlimb muscles of SOD1(G93A) mice at 70 days of age, at symptom onset.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  3. 03AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome

    In SOD1(G93A) mice, delivery of an MGF expression plasmid increased motoneuron survival.

    In plain wordsIn mice with an ALS-like disease, a gene-delivery plasmid for MGF helped more motor nerve cells survive.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMotoneuron survival
    Study

    mousen: not reported in source

    SOD1(G93A) mouse model of ALS
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    an increase in motor unit and motoneuron survival.
    1 context sentence
    Summary · context
    A mammalian expression plasmid containing either MGF or, for comparison, the IGF-I cDNA sequence was delivered to the hindlimb muscles of SOD1(G93A) mice at 70 days of age, at symptom onset.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  4. 04AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome

    In SOD1(G93A) mice, significantly more motoneurons survived in MGF-treated mice than with the IGF-I comparison plasmid.

    In plain wordsIn mice with an ALS-like disease, more motor nerve cells survived with the MGF plasmid than with the IGF-I plasmid.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMotoneuron survival, MGF versus IGF-I plasmid
    Study

    mousen: not reported in source

    SOD1(G93A) mouse model of ALS
    Comparator
    IGF-I plasmid
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Significantly more motoneurons survived in MGF treated mice.
    1 context sentence
    Summary · context
    A mammalian expression plasmid containing either MGF or, for comparison, the IGF-I cDNA sequence was delivered to the hindlimb muscles of SOD1(G93A) mice at 70 days of age, at symptom onset.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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