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Study · Non-randomized trial · n = 20 · 2008

5 results

[Cerebrolysin alleviates perinatal CNS disorders through the autoimmune modulation and antioxidant protection].

Serkina EV, Gromova OA, Torshin IIu, Sotnikova NIu, Nikonov AA

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2008Cited by 1 (Europe PMC)

PMID19008804 (opens in a new tab)PepBankPUB-19008804
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanNon-randomized trialMechanism

    In newborns with perinatal ischemic CNS damage, cerebrolysin increased Fas, reported as part of normalized T-lymphocyte apoptosis (p<0.001).

    In plain wordsIn newborns with ischemic brain damage, cerebrolysin increased Fas, which the authors described as normalizing immune cell death.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseFas
    Study

    n = 20

    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0,1 ml per 1 kg of body mass · 10 injections every other dayAs given in this study (human).

    Source sentences

    Summary
    The treatment with cerebrolysin in dosage of 0,1 ml per 1 kg of body mass, 10 injections every other day, resulted in the normalization (p<0,001) of the T-lymphocyte apoptosis (the increase of Fas and decrease of FasL) and activation of antioxidant protection through the increase of metallotionein-1 expression.
    1 context sentence
    Summary · context
    We investigated the effects of the neuroprotective drug cerebrolysin on the autoimmune parameters (FasL, Fas and metallotionein-1) in 20 newborns with perinatal ischemic CNS damage and 20 healthy newborns.
  2. 02HumanNon-randomized trialMechanism

    In newborns with perinatal ischemic CNS damage, cerebrolysin decreased FasL, reported as part of normalized T-lymphocyte apoptosis (p<0.001).

    In plain wordsIn newborns with ischemic brain damage, cerebrolysin decreased FasL, which the authors described as normalizing immune cell death.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseFasL
    Study

    n = 20

    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0,1 ml per 1 kg of body mass · 10 injections every other dayAs given in this study (human).

    Source sentences

    Summary
    The treatment with cerebrolysin in dosage of 0,1 ml per 1 kg of body mass, 10 injections every other day, resulted in the normalization (p<0,001) of the T-lymphocyte apoptosis (the increase of Fas and decrease of FasL) and activation of antioxidant protection through the increase of metallotionein-1 expression.
    1 context sentence
    Summary · context
    We investigated the effects of the neuroprotective drug cerebrolysin on the autoimmune parameters (FasL, Fas and metallotionein-1) in 20 newborns with perinatal ischemic CNS damage and 20 healthy newborns.
  3. 03HumanNon-randomized trialMechanism

    In newborns with perinatal ischemic CNS damage, cerebrolysin increased metallotionein-1 expression.

    In plain wordsIn newborns with ischemic brain damage, cerebrolysin increased an antioxidant protection marker.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseMetallotionein-1 expression
    Study

    n = 20

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0,1 ml per 1 kg of body mass · 10 injections every other dayAs given in this study (human).

    Source sentences

    Summary
    The treatment with cerebrolysin in dosage of 0,1 ml per 1 kg of body mass, 10 injections every other day, resulted in the normalization (p<0,001) of the T-lymphocyte apoptosis (the increase of Fas and decrease of FasL) and activation of antioxidant protection through the increase of metallotionein-1 expression.
    1 context sentence
    Summary · context
    We investigated the effects of the neuroprotective drug cerebrolysin on the autoimmune parameters (FasL, Fas and metallotionein-1) in 20 newborns with perinatal ischemic CNS damage and 20 healthy newborns.
  4. 04HumanNon-randomized trialEfficacy outcome

    In newborns with ischemic CNS damage, normalization of autoimmunity after cerebrolysin treatment was linked to reduced edema.

    In plain wordsIn newborns with ischemic brain damage, immune normalization after cerebrolysin was linked to less edema.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseBrain edema
    Study

    n = 20

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0,1 ml per 1 kg of body mass · 10 injections every other dayAs given in this study (human).

    Source sentences

    Summary
    The normalization of the autoimmunity was found to reduce edema and improve the circulation of the brain sites affected with ischemia.
    1 context sentence
    Summary · context
    We investigated the effects of the neuroprotective drug cerebrolysin on the autoimmune parameters (FasL, Fas and metallotionein-1) in 20 newborns with perinatal ischemic CNS damage and 20 healthy newborns.
  5. 05HumanNon-randomized trialEfficacy outcome

    In newborns with ischemic CNS damage, normalization of autoimmunity after cerebrolysin treatment was linked to improved circulation in affected brain sites.

    In plain wordsIn newborns with ischemic brain damage, immune normalization after cerebrolysin was linked to better circulation in affected brain areas.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseBrain circulation
    Study

    n = 20

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0,1 ml per 1 kg of body mass · 10 injections every other dayAs given in this study (human).

    Source sentences

    Summary
    The normalization of the autoimmunity was found to reduce edema and improve the circulation of the brain sites affected with ischemia.
    1 context sentence
    Summary · context
    We investigated the effects of the neuroprotective drug cerebrolysin on the autoimmune parameters (FasL, Fas and metallotionein-1) in 20 newborns with perinatal ischemic CNS damage and 20 healthy newborns.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

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