In rats with area postrema lesions, third-ventricle injection of melanotan II suppressed meal size.
In plain wordsIn rats with a lesion in one brain area, melanotan II injected into the brain reduced meal size.
- Peptide
- Melanotan II
- Outcome
- DecreaseMeal size after third-ventricle MTII in area postrema lesioned rats
- Study
ratn: not reported in source
in vivo, rats with dorsal medullary (area postrema) lesions- Outcome group
- Appetite and food intake · Metabolic and weight
- Studied dose
- 1 nm · third ventricle injectionAs given in this study (rat).
Source sentences
They also showed meal size suppression after 3V injection of the melanocortin-3/4 receptor agonist melanotan II (1 nm).
1 context sentence(design, population, supporting numbers)
In experiment 3, rats with cannulas in the third ventricle (3V) received dorsal medullary lesions centered on the area postrema (APX group) or sham procedures, and licking for water and 0.1 and 1 m sucrose was evaluated after 1 nm 3V ORXA/artificial cerebrospinal fluid injections.