Cerebrolysin lowers kynurenic acid formation--an in vitro study.

Baran H, Kepplinger B

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology12 Nov 2008Cited by 12 (Europe PMC)

PMID19008081DOI10.1016/j.euroneuro.2008.09.003PepBankPUB-19008081

Publisher page PubMedAsk about this study

Jump to 11 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cell-free)Mechanism
In rat liver homogenate, Cerebrolysin dose-dependently and significantly reduced KAT I activity.
In plain wordsIn lab tests with rat liver homogenate, Cerebrolysin significantly reduced KAT I activity as the dose increased.
Peptide
Cerebrolysin
Outcome
DecreaseRat liver KAT I activity
Study
ratn: not reported in source
Liver homogenate
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
Cerebrolysin, dose-dependently and significantly reduced KAT I, KAT II and KAT III activities of rat liver homogenate.
1 context sentence(design, population, supporting numbers)
Summary · context
The activities of the KYNA synthesizing enzymes kynurenine aminotransferases I, II and III (KAT I, KAT II and KAT III) in rat liver, and rat and human brain homogenates were analysed in the presence of Cerebrolysin.
Report a problemFND-1900808101
02LabIn vitro (cell-free)Mechanism
In rat liver homogenate, Cerebrolysin dose-dependently and significantly reduced KAT II activity.
In plain wordsIn lab tests with rat liver homogenate, Cerebrolysin significantly reduced KAT II activity as the dose increased.
Peptide
Cerebrolysin
Outcome
DecreaseRat liver KAT II activity
Study
ratn: not reported in source
Liver homogenate
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
Cerebrolysin, dose-dependently and significantly reduced KAT I, KAT II and KAT III activities of rat liver homogenate.
1 context sentence(design, population, supporting numbers)
Summary · context
The activities of the KYNA synthesizing enzymes kynurenine aminotransferases I, II and III (KAT I, KAT II and KAT III) in rat liver, and rat and human brain homogenates were analysed in the presence of Cerebrolysin.
Report a problemFND-1900808102
03LabIn vitro (cell-free)Mechanism
In rat liver homogenate, Cerebrolysin dose-dependently and significantly reduced KAT III activity.
In plain wordsIn lab tests with rat liver homogenate, Cerebrolysin significantly reduced KAT III activity as the dose increased.
Peptide
Cerebrolysin
Outcome
DecreaseRat liver KAT III activity
Study
ratn: not reported in source
Liver homogenate
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
Cerebrolysin, dose-dependently and significantly reduced KAT I, KAT II and KAT III activities of rat liver homogenate.
1 context sentence(design, population, supporting numbers)
Summary · context
The activities of the KYNA synthesizing enzymes kynurenine aminotransferases I, II and III (KAT I, KAT II and KAT III) in rat liver, and rat and human brain homogenates were analysed in the presence of Cerebrolysin.
Report a problemFND-1900808103
04LabIn vitro (cell-free)Mechanism
In rat brain homogenate, Cerebrolysin dose-dependently inhibited KAT I activity.
In plain wordsIn lab tests with rat brain homogenate, Cerebrolysin inhibited KAT I activity as the dose increased.
Peptide
Cerebrolysin
Outcome
DecreaseRat brain KAT I activity
Study
ratn: not reported in source
Brain homogenate
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
Furthermore, Cerebrolysin exerted a dose-dependent inhibition of rat and human brain KAT I, KAT II and KAT III activities, too.
1 context sentence(design, population, supporting numbers)
Summary · context
The activities of the KYNA synthesizing enzymes kynurenine aminotransferases I, II and III (KAT I, KAT II and KAT III) in rat liver, and rat and human brain homogenates were analysed in the presence of Cerebrolysin.
Report a problemFND-1900808104
05LabIn vitro (cell-free)Mechanism
In rat brain homogenate, Cerebrolysin dose-dependently inhibited KAT II activity.
In plain wordsIn lab tests with rat brain homogenate, Cerebrolysin inhibited KAT II activity as the dose increased.
Peptide
Cerebrolysin
Outcome
DecreaseRat brain KAT II activity
Study
ratn: not reported in source
Brain homogenate
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
Furthermore, Cerebrolysin exerted a dose-dependent inhibition of rat and human brain KAT I, KAT II and KAT III activities, too.
1 context sentence(design, population, supporting numbers)
Summary · context
The activities of the KYNA synthesizing enzymes kynurenine aminotransferases I, II and III (KAT I, KAT II and KAT III) in rat liver, and rat and human brain homogenates were analysed in the presence of Cerebrolysin.
Report a problemFND-1900808105
06LabIn vitro (cell-free)Mechanism
In rat brain homogenate, Cerebrolysin dose-dependently inhibited KAT III activity.
In plain wordsIn lab tests with rat brain homogenate, Cerebrolysin inhibited KAT III activity as the dose increased.
Peptide
Cerebrolysin
Outcome
DecreaseRat brain KAT III activity
Study
ratn: not reported in source
Brain homogenate
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
Furthermore, Cerebrolysin exerted a dose-dependent inhibition of rat and human brain KAT I, KAT II and KAT III activities, too.
1 context sentence(design, population, supporting numbers)
Summary · context
The activities of the KYNA synthesizing enzymes kynurenine aminotransferases I, II and III (KAT I, KAT II and KAT III) in rat liver, and rat and human brain homogenates were analysed in the presence of Cerebrolysin.
Report a problemFND-1900808106
07LabIn vitro (cell-free)Mechanism
In human brain homogenate, Cerebrolysin dose-dependently inhibited KAT I activity.
In plain wordsIn lab tests with human brain homogenate, Cerebrolysin inhibited KAT I activity as the dose increased.
Peptide
Cerebrolysin
Outcome
DecreaseHuman brain KAT I activity
Study
humann: not reported in source
Brain homogenate
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
Furthermore, Cerebrolysin exerted a dose-dependent inhibition of rat and human brain KAT I, KAT II and KAT III activities, too.
1 context sentence(design, population, supporting numbers)
Summary · context
The activities of the KYNA synthesizing enzymes kynurenine aminotransferases I, II and III (KAT I, KAT II and KAT III) in rat liver, and rat and human brain homogenates were analysed in the presence of Cerebrolysin.
Report a problemFND-1900808107
08LabIn vitro (cell-free)Mechanism
In human brain homogenate, Cerebrolysin dose-dependently inhibited KAT II activity.
In plain wordsIn lab tests with human brain homogenate, Cerebrolysin inhibited KAT II activity as the dose increased.
Peptide
Cerebrolysin
Outcome
DecreaseHuman brain KAT II activity
Study
humann: not reported in source
Brain homogenate
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
Furthermore, Cerebrolysin exerted a dose-dependent inhibition of rat and human brain KAT I, KAT II and KAT III activities, too.
1 context sentence(design, population, supporting numbers)
Summary · context
The activities of the KYNA synthesizing enzymes kynurenine aminotransferases I, II and III (KAT I, KAT II and KAT III) in rat liver, and rat and human brain homogenates were analysed in the presence of Cerebrolysin.
Report a problemFND-1900808108
09LabIn vitro (cell-free)Mechanism
In human brain homogenate, Cerebrolysin dose-dependently inhibited KAT III activity.
In plain wordsIn lab tests with human brain homogenate, Cerebrolysin inhibited KAT III activity as the dose increased.
Peptide
Cerebrolysin
Outcome
DecreaseHuman brain KAT III activity
Study
humann: not reported in source
Brain homogenate
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
Furthermore, Cerebrolysin exerted a dose-dependent inhibition of rat and human brain KAT I, KAT II and KAT III activities, too.
1 context sentence(design, population, supporting numbers)
Summary · context
The activities of the KYNA synthesizing enzymes kynurenine aminotransferases I, II and III (KAT I, KAT II and KAT III) in rat liver, and rat and human brain homogenates were analysed in the presence of Cerebrolysin.
Report a problemFND-1900808109
10LabIn vitro (cell-free)Mechanism
In homogenate assays, Cerebrolysin inhibited KAT I more strongly than KAT II.
In plain wordsIn lab tests with homogenates, Cerebrolysin inhibited KAT I more strongly than KAT II.
Peptide
Cerebrolysin
Outcome
IncreaseKAT I inhibition relative to KAT II
Study
n: not reported in source
Rat liver and rat and human brain homogenates
Comparator
KAT II inhibition
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
The inhibitory effect of Cerebrolysin was more pronounced for KAT I than for KAT II and KAT III.
1 context sentence(design, population, supporting numbers)
Summary · context
The activities of the KYNA synthesizing enzymes kynurenine aminotransferases I, II and III (KAT I, KAT II and KAT III) in rat liver, and rat and human brain homogenates were analysed in the presence of Cerebrolysin.
Report a problemFND-1900808110
11LabIn vitro (cell-free)Mechanism
In homogenate assays, Cerebrolysin inhibited KAT I more strongly than KAT III.
In plain wordsIn lab tests with homogenates, Cerebrolysin inhibited KAT I more strongly than KAT III.
Peptide
Cerebrolysin
Outcome
IncreaseKAT I inhibition relative to KAT III
Study
n: not reported in source
Rat liver and rat and human brain homogenates
Comparator
KAT III inhibition
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
The inhibitory effect of Cerebrolysin was more pronounced for KAT I than for KAT II and KAT III.
1 context sentence(design, population, supporting numbers)
Summary · context
The activities of the KYNA synthesizing enzymes kynurenine aminotransferases I, II and III (KAT I, KAT II and KAT III) in rat liver, and rat and human brain homogenates were analysed in the presence of Cerebrolysin.
Report a problemFND-1900808111

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.