Cerebrolysin and morphine decrease glutathione and 5-hydroxyindole acetic acid levels in fasted rat brain.

Guzmán DC, Brizuela NO, Alvarez RG, García EH, Mejía GB, Olguín HJ

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie23 Oct 2008Cited by 13 (Europe PMC)

PMID18993027DOI10.1016/j.biopha.2008.09.013PepBankPUB-18993027

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In fasted Wistar rats, Cerebrolysin alone significantly decreased brain glutathione levels (p<0.05).
In plain wordsIn fasted Wistar rats, Cerebrolysin alone significantly decreased brain glutathione levels.
Peptide
Cerebrolysin
Outcome
DecreaseBrain glutathione levels with Cerebrolysin alone
Study
Wistar ratn: not reported in source
Starvation for 48h with moderate hypoglycaemia
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
215 mg/kgAs given in this study (Wistar rat).
Source sentences
Summary
GSH and 5-HIAA levels decreased significantly (p<0.05) in animals which received cerebrolysin and morphine alone or combined.
1 context sentence(design, population, supporting numbers)
Summary · context
Wistar rats under starvation for 48h received a single dose of 215 mg/kg cerebrolysin or 4 mg/kg morphine sulphate.
Report a problemFND-1899302701
02AnimalAnimal study (in vivo)Mechanism
In fasted Wistar rats, Cerebrolysin alone significantly decreased brain 5-HIAA levels (p<0.05).
In plain wordsIn fasted Wistar rats, Cerebrolysin alone significantly decreased brain 5-HIAA levels.
Peptide
Cerebrolysin
Outcome
DecreaseBrain 5-HIAA levels with Cerebrolysin alone
Study
Wistar ratn: not reported in source
Starvation for 48h with moderate hypoglycaemia
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
215 mg/kgAs given in this study (Wistar rat).
Source sentences
Summary
GSH and 5-HIAA levels decreased significantly (p<0.05) in animals which received cerebrolysin and morphine alone or combined.
1 context sentence(design, population, supporting numbers)
Summary · context
Wistar rats under starvation for 48h received a single dose of 215 mg/kg cerebrolysin or 4 mg/kg morphine sulphate.
Report a problemFND-1899302702
03AnimalAnimal study (in vivo)Mechanism
In fasted Wistar rats, TBARS increased in all groups, but the increase with Cerebrolysin alone was not statistically significant.
In plain wordsIn fasted Wistar rats, TBARS increased in all groups, but the increase with Cerebrolysin alone was not statistically significant.
Peptide
Cerebrolysin
Outcome
No significant changeBrain TBARS levels with Cerebrolysin alone
Study
Wistar ratn: not reported in source
Starvation for 48h with moderate hypoglycaemia
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
215 mg/kgAs given in this study (Wistar rat).
Source sentences
Summary
TBARS levels increased in all groups, but the values were statistically significant only in those animals that received cerebrolysin combined with morphine (p<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Wistar rats under starvation for 48h received a single dose of 215 mg/kg cerebrolysin or 4 mg/kg morphine sulphate.
Report a problemFND-1899302705

Studies that did not test the peptide alone5

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

04AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In fasted Wistar rats, combined Cerebrolysin and morphine significantly decreased brain glutathione levels (p<0.05).
In plain wordsIn fasted Wistar rats, combined Cerebrolysin and morphine significantly decreased brain glutathione levels.
Peptide
Cerebrolysin
Outcome
DecreaseBrain glutathione levels with Cerebrolysin and morphine
Study
Wistar ratn: not reported in source
Starvation for 48h with moderate hypoglycaemia
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
GSH and 5-HIAA levels decreased significantly (p<0.05) in animals which received cerebrolysin and morphine alone or combined.
1 context sentence(design, population, supporting numbers)
Summary · context
Wistar rats under starvation for 48h received a single dose of 215 mg/kg cerebrolysin or 4 mg/kg morphine sulphate.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-1899302703
05AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In fasted Wistar rats, combined Cerebrolysin and morphine significantly decreased brain 5-HIAA levels (p<0.05).
In plain wordsIn fasted Wistar rats, combined Cerebrolysin and morphine significantly decreased brain 5-HIAA levels.
Peptide
Cerebrolysin
Outcome
DecreaseBrain 5-HIAA levels with Cerebrolysin and morphine
Study
Wistar ratn: not reported in source
Starvation for 48h with moderate hypoglycaemia
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
GSH and 5-HIAA levels decreased significantly (p<0.05) in animals which received cerebrolysin and morphine alone or combined.
1 context sentence(design, population, supporting numbers)
Summary · context
Wistar rats under starvation for 48h received a single dose of 215 mg/kg cerebrolysin or 4 mg/kg morphine sulphate.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-1899302704
06AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In fasted Wistar rats, TBARS increased in all groups, with a significant increase only after combined Cerebrolysin and morphine (p<0.05).
In plain wordsIn fasted Wistar rats, TBARS increased in all groups, with a significant increase only after combined Cerebrolysin and morphine.
Peptide
Cerebrolysin
Outcome
IncreaseBrain TBARS levels with Cerebrolysin and morphine
Study
Wistar ratn: not reported in source
Starvation for 48h with moderate hypoglycaemia
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
TBARS levels increased in all groups, but the values were statistically significant only in those animals that received cerebrolysin combined with morphine (p<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Wistar rats under starvation for 48h received a single dose of 215 mg/kg cerebrolysin or 4 mg/kg morphine sulphate.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-1899302706
07AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In fasted Wistar rats, the reported Cerebrolysin and morphine groups showed significantly increased Na(+)-K(+) ATPase activity; the arm attribution is unclear.
In plain wordsIn fasted Wistar rats, the reported Cerebrolysin and morphine groups showed increased Na(+)-K(+) ATPase activity; the arm attribution is unclear.
Peptide
Cerebrolysin
Outcome
IncreaseNa(+)-K(+) ATPase activity in Cerebrolysin and morphine groups
Study
Wistar ratn: not reported in source
Starvation for 48h with moderate hypoglycaemia
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Na(+)-K(+) ATPase and total ATPase activities decreased significantly in rats treated only with morphine, but the cerebrolysin and morphine groups showed a significant increase in these enzymatic activities.
1 context sentence(design, population, supporting numbers)
Summary · context
Wistar rats under starvation for 48h received a single dose of 215 mg/kg cerebrolysin or 4 mg/kg morphine sulphate.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-1899302707
08AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In fasted Wistar rats, the reported Cerebrolysin and morphine groups showed significantly increased total ATPase activity; the arm attribution is unclear.
In plain wordsIn fasted Wistar rats, the reported Cerebrolysin and morphine groups showed increased total ATPase activity; the arm attribution is unclear.
Peptide
Cerebrolysin
Outcome
IncreaseTotal ATPase activity in Cerebrolysin and morphine groups
Study
Wistar ratn: not reported in source
Starvation for 48h with moderate hypoglycaemia
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Na(+)-K(+) ATPase and total ATPase activities decreased significantly in rats treated only with morphine, but the cerebrolysin and morphine groups showed a significant increase in these enzymatic activities.
1 context sentence(design, population, supporting numbers)
Summary · context
Wistar rats under starvation for 48h received a single dose of 215 mg/kg cerebrolysin or 4 mg/kg morphine sulphate.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-1899302708

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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