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Study · Measured the body's own peptide · 2009

2 results

Release of regulatory gut peptides somatostatin, neurotensin and vasoactive intestinal peptide by acid and hyperosmolal solutions in the intestine in conscious rats.

Rudholm T, Wallin B, Theodorsson E, Näslund E, Hellström PM

Regulatory peptides10 Oct 2008Cited by 24 (Europe PMC)

PMID18992283 (opens in a new tab)DOI10.1016/j.regpep.2008.10.002 (opens in a new tab)PepBankPUB-18992283
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In conscious rats, acid perfusion of the jejunal loop did not release the body's own VIP to the same extent as somatostatin.

    In plain wordsIn rats, acid in the gut released the body's own VIP much less than it released somatostatin.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Direction not reportedVIP release with acid perfusion of the loop
    Study

    ratn: not reported in source

    conscious rats with gastric fistula and Thiry-Vella jejunal loop
    Outcome group
    Endogenous peptide levels · Gastrointestinal

    Source sentences

    Summary
    The release of NT and VIP was not affected to the same extent.
    1 context sentence
    Summary · context
    The animals were equipped with a chronic gastric fistula to measure acid secretion and a jejunal Thiry-Vella loop for intestinal challenge with saline, hydrochloric acid (HCl, 200 mmol L(-1)) or hyperosmolal polyethylene glycol (PEG, 1200 mOsm kg(-1)).

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In conscious rats, hyperosmolal PEG perfusion of the jejunal loop released the body's own VIP, but less than somatostatin.

    In plain wordsIn rats, a concentrated solution in the gut released the body's own VIP, but less than somatostatin.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseVIP release with hyperosmolal PEG perfusion of the loop
    Study

    ratn: not reported in source

    conscious rats with gastric fistula and Thiry-Vella jejunal loop
    Outcome group
    Endogenous peptide levels · Gastrointestinal

    Source sentences

    Summary
    PEG perfusion of the loop caused a release of SOM as well as NT and VIP, but less.
    1 context sentence
    Summary · context
    The animals were equipped with a chronic gastric fistula to measure acid secretion and a jejunal Thiry-Vella loop for intestinal challenge with saline, hydrochloric acid (HCl, 200 mmol L(-1)) or hyperosmolal polyethylene glycol (PEG, 1200 mOsm kg(-1)).

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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