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Study · Animal study (in vivo) · mouse · 2008

9 results

Thymulin, a thymic peptide, prevents the overproduction of pro-inflammatory cytokines and heat shock protein Hsp70 in inflammation-bearing mice.

Lunin SM, Khrenov MO, Novoselova TV, Parfenyuk SB, Novoselova EG

Immunological investigations1 Jan 2008Cited by 20 (Europe PMC)

PMID18991101 (opens in a new tab)DOI10.1080/08820130802447629 (opens in a new tab)PepBankPUB-18991101
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In LPS-treated mice, thymulin prevented plasma IL-1 beta accumulation.

    In plain wordsIn mice, thymulin prevented IL-1 beta accumulation in blood after LPS exposure.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreasePlasma IL-1 beta accumulation
    Study

    mousen: not reported in source

    LPS-induced inflammation in male NMRI mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    15 microg/100 g body weight · injectionAs given in this study (mouse).

    Source sentences

    Summary
    Thymulin previously injected in dose of 15 microg/100 g body weight, prevented the accumulation of proinflammatory cytokines in plasma.
    2 context sentences
    Summary · context
    Inflammation induced by LPS resulted in accumulation of several plasma pro-inflammatory cytokines, IL-1 beta, IL-2, IL-6, TNF-alpha, interferon-gamma, and also IL-10, anti-inflammatory cytokine.
    Summary · context
    The effects of synthetic analogue of peptide hormone thymulin, which is normally produced by thymic epithelial cells, on immune cells activity and blood cytokine profile had been studied in male NMRI mice with acute inflammation induced by injection of lipopolysaccharide from gram-negative bacteria…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In LPS-treated mice, thymulin prevented increased cytokine production by spleen lymphocytes.

    In plain wordsIn mice, thymulin prevented increased cytokine production by spleen immune cells after LPS exposure.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseSplenic lymphocyte cytokine production
    Study

    mousen: not reported in source

    LPS-induced inflammation in male NMRI mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    15 microg/100 g body weight · injectionAs given in this study (mouse).

    Source sentences

    Summary
    Thymulin also prevented LPS-induced up-regulation of production of several cytokines by spleen lymphocytes and peritoneal macrophages.
    1 context sentence
    Summary · context
    The effects of synthetic analogue of peptide hormone thymulin, which is normally produced by thymic epithelial cells, on immune cells activity and blood cytokine profile had been studied in male NMRI mice with acute inflammation induced by injection of lipopolysaccharide from gram-negative bacteria…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In LPS-treated mice, thymulin prevented increased cytokine production by peritoneal macrophages.

    In plain wordsIn mice, thymulin prevented increased cytokine production by peritoneal macrophages after LPS exposure.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreasePeritoneal macrophage cytokine production
    Study

    mousen: not reported in source

    LPS-induced inflammation in male NMRI mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    15 microg/100 g body weight · injectionAs given in this study (mouse).

    Source sentences

    Summary
    Thymulin also prevented LPS-induced up-regulation of production of several cytokines by spleen lymphocytes and peritoneal macrophages.
    1 context sentence
    Summary · context
    The effects of synthetic analogue of peptide hormone thymulin, which is normally produced by thymic epithelial cells, on immune cells activity and blood cytokine profile had been studied in male NMRI mice with acute inflammation induced by injection of lipopolysaccharide from gram-negative bacteria…
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In LPS-treated mice, thymulin prevented plasma IL-2 accumulation.

    In plain wordsIn mice, thymulin prevented IL-2 accumulation in blood after LPS exposure.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreasePlasma IL-2 accumulation
    Study

    mousen: not reported in source

    LPS-induced inflammation in male NMRI mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    15 microg/100 g body weight · injectionAs given in this study (mouse).

    Source sentences

    Summary
    Thymulin previously injected in dose of 15 microg/100 g body weight, prevented the accumulation of proinflammatory cytokines in plasma.
    2 context sentences
    Summary · context
    Inflammation induced by LPS resulted in accumulation of several plasma pro-inflammatory cytokines, IL-1 beta, IL-2, IL-6, TNF-alpha, interferon-gamma, and also IL-10, anti-inflammatory cytokine.
    Summary · context
    The effects of synthetic analogue of peptide hormone thymulin, which is normally produced by thymic epithelial cells, on immune cells activity and blood cytokine profile had been studied in male NMRI mice with acute inflammation induced by injection of lipopolysaccharide from gram-negative bacteria…
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In LPS-treated mice, thymulin prevented plasma IL-6 accumulation.

    In plain wordsIn mice, thymulin prevented IL-6 accumulation in blood after LPS exposure.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreasePlasma IL-6 accumulation
    Study

    mousen: not reported in source

    LPS-induced inflammation in male NMRI mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    15 microg/100 g body weight · injectionAs given in this study (mouse).

    Source sentences

    Summary
    Thymulin previously injected in dose of 15 microg/100 g body weight, prevented the accumulation of proinflammatory cytokines in plasma.
    2 context sentences
    Summary · context
    Inflammation induced by LPS resulted in accumulation of several plasma pro-inflammatory cytokines, IL-1 beta, IL-2, IL-6, TNF-alpha, interferon-gamma, and also IL-10, anti-inflammatory cytokine.
    Summary · context
    The effects of synthetic analogue of peptide hormone thymulin, which is normally produced by thymic epithelial cells, on immune cells activity and blood cytokine profile had been studied in male NMRI mice with acute inflammation induced by injection of lipopolysaccharide from gram-negative bacteria…
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In LPS-treated mice, thymulin prevented plasma TNF-alpha accumulation.

    In plain wordsIn mice, thymulin prevented TNF-alpha accumulation in blood after LPS exposure.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreasePlasma TNF-alpha accumulation
    Study

    mousen: not reported in source

    LPS-induced inflammation in male NMRI mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    15 microg/100 g body weight · injectionAs given in this study (mouse).

    Source sentences

    Summary
    Thymulin previously injected in dose of 15 microg/100 g body weight, prevented the accumulation of proinflammatory cytokines in plasma.
    2 context sentences
    Summary · context
    Inflammation induced by LPS resulted in accumulation of several plasma pro-inflammatory cytokines, IL-1 beta, IL-2, IL-6, TNF-alpha, interferon-gamma, and also IL-10, anti-inflammatory cytokine.
    Summary · context
    The effects of synthetic analogue of peptide hormone thymulin, which is normally produced by thymic epithelial cells, on immune cells activity and blood cytokine profile had been studied in male NMRI mice with acute inflammation induced by injection of lipopolysaccharide from gram-negative bacteria…
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In LPS-treated mice, thymulin prevented plasma interferon-gamma accumulation.

    In plain wordsIn mice, thymulin prevented interferon-gamma accumulation in blood after LPS exposure.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreasePlasma interferon-gamma accumulation
    Study

    mousen: not reported in source

    LPS-induced inflammation in male NMRI mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    15 microg/100 g body weight · injectionAs given in this study (mouse).

    Source sentences

    Summary
    Thymulin previously injected in dose of 15 microg/100 g body weight, prevented the accumulation of proinflammatory cytokines in plasma.
    2 context sentences
    Summary · context
    Inflammation induced by LPS resulted in accumulation of several plasma pro-inflammatory cytokines, IL-1 beta, IL-2, IL-6, TNF-alpha, interferon-gamma, and also IL-10, anti-inflammatory cytokine.
    Summary · context
    The effects of synthetic analogue of peptide hormone thymulin, which is normally produced by thymic epithelial cells, on immune cells activity and blood cytokine profile had been studied in male NMRI mice with acute inflammation induced by injection of lipopolysaccharide from gram-negative bacteria…
  8. 08LabIn vitro (cells)Efficacy outcome

    In macrophages cultured with LPS, thymulin decreased peak TNF-alpha production.

    In plain wordsIn cells exposed to LPS, thymulin reduced peak TNF-alpha production.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseMacrophage peak TNF-alpha production
    Study

    mousen: not reported in source

    Macrophages cultured with LPS
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Added in vitro, thymulin decreased the peak of TNF-alpha production in macrophages cultivated with LPS.
    1 context sentence
    Summary · context
    The effects of synthetic analogue of peptide hormone thymulin, which is normally produced by thymic epithelial cells, on immune cells activity and blood cytokine profile had been studied in male NMRI mice with acute inflammation induced by injection of lipopolysaccharide from gram-negative bacteria…
  9. 09LabIn vitro (cells)Efficacy outcome

    In macrophages cultured with LPS, thymulin lowered peak Hsp70 production.

    In plain wordsIn cells exposed to LPS, thymulin reduced peak Hsp70 production.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreasePeak Hsp70 production
    Study

    mousen: not reported in source

    Macrophages cultured with LPS
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, thymulin lowered the peak of Hsp70 production induced by LPS treatment.
    2 context sentences
    Summary · context
    Added in vitro, thymulin decreased the peak of TNF-alpha production in macrophages cultivated with LPS.
    Summary · context
    The effects of synthetic analogue of peptide hormone thymulin, which is normally produced by thymic epithelial cells, on immune cells activity and blood cytokine profile had been studied in male NMRI mice with acute inflammation induced by injection of lipopolysaccharide from gram-negative bacteria…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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