Cancellous and cortical bone architecture and turnover at the iliac crest of postmenopausal osteoporotic women treated with parathyroid hormone 1-84.

In osteoporotic women, cancellous bone volume was 45-48% higher after PTH(1-84) than placebo at 18 months.

In plain wordsIn women with osteoporosis, cancellous bone volume was 45-48% higher with PTH than placebo at 18 months.

Measurements

Cancellous bone volume (BV/TV) higher with PTH(1-84) versus placebo

45 to 48%

18 months, microCT and histomorphometry

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In osteoporotic women, PTH(1-84) increased trabecular number versus placebo at 18 months.

In plain wordsIn women with osteoporosis, trabecular number was higher with PTH than placebo.

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In osteoporotic women, PTH(1-84) increased trabecular thickness versus placebo at 18 months.

In plain wordsIn women with osteoporosis, trabecular thickness was higher with PTH than placebo.

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In osteoporotic women, connectivity density was higher with PTH(1-84) than placebo.

In plain wordsIn women with osteoporosis, bone connectivity density was higher with PTH than placebo.

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In osteoporotic women, structure model index was lower with PTH(1-84) than placebo.

In plain wordsIn women with osteoporosis, bone structure model index was lower with PTH than placebo.

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In osteoporotic women, cancellous bone formation rate was 2-fold higher with PTH(1-84) than placebo.

In plain wordsIn women with osteoporosis, cancellous bone formation was 2-fold higher with PTH than placebo.

Measurements

Cancellous bone formation rate with PTH(1-84) versus placebo

2 fold

PTH(1-84)-treated subjects

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In osteoporotic women, mineralizing surface was greater with PTH(1-84) than placebo.

In plain wordsIn women with osteoporosis, mineralizing bone surface was greater with PTH than placebo.

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In osteoporotic women, osteoblast surface was nonsignificantly 58% higher with PTH(1-84) than placebo.

In plain wordsIn women with osteoporosis, osteoblast surface was 58% higher with PTH than placebo, without statistical significance.

Measurements

Osteoblast surface higher with PTH(1-84)

58%

reported as nonsignificant

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In osteoporotic women, osteoid surface was nonsignificantly 35% higher with PTH(1-84) than placebo.

In plain wordsIn women with osteoporosis, osteoid surface was 35% higher with PTH than placebo, without statistical significance.

Measurements

Osteoid surface higher with PTH(1-84)

35%

reported as nonsignificant

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In osteoporotic women, PTH(1-84) did not affect osteoclast surface versus placebo.

In plain wordsIn women with osteoporosis, PTH did not affect osteoclast surface versus placebo.

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In osteoporotic women, PTH(1-84) did not affect eroded surface versus placebo.

In plain wordsIn women with osteoporosis, PTH did not affect eroded bone surface versus placebo.

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In osteoporotic women, PTH(1-84) did not affect cortical thickness versus placebo.

In plain wordsIn women with osteoporosis, PTH did not affect cortical thickness versus placebo.

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In osteoporotic women, PTH(1-84) did not affect endocortical bone formation rate versus placebo.

In plain wordsIn women with osteoporosis, PTH did not affect endocortical bone formation versus placebo.

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In osteoporotic women, PTH(1-84) did not affect periosteal bone formation rate versus placebo.

In plain wordsIn women with osteoporosis, PTH did not affect periosteal bone formation versus placebo.

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In osteoporotic women, cortical porosity tended to be higher with PTH(1-84) than placebo.

In plain wordsIn women with osteoporosis, cortical porosity tended to be higher with PTH than placebo.

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In osteoporotic women receiving PTH(1-84), cancellous bone formation rate was lower at 24 than at 18 months.

In plain wordsIn women receiving PTH, cancellous bone formation was lower at 24 than at 18 months.

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In osteoporotic women receiving PTH(1-84), cancellous and cortical structure measures were similar at 24 and 18 months.

In plain wordsIn women receiving PTH, cancellous and cortical bone structure was similar at 24 and 18 months.

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In osteoporotic women, bone produced during PTH(1-84) treatment had normal lamellar structure and mineralization without abnormal histology.

In plain wordsIn women with osteoporosis, bone produced during PTH treatment had normal structure and mineralization without abnormal histology.

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In osteoporotic women given PTH(1-84), higher trabecular number appeared to result from intratrabecular tunneling.

In plain wordsIn women given PTH, higher trabecular number appeared to result from tunneling within bone struts.

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