Delta sleep-inducing peptide and Deltaran: potential approaches to antistress protection.

Koplik EV, Umryukhin PE, Konorova IL, Terekhina OL, Mikhaleva II, Gannushkina IV, Sudakov KV

Neuroscience and behavioral physiology1 Nov 2008Cited by 6 (Europe PMC)

PMID18975104DOI10.1007/s11055-008-9076-4PepBankPUB-18975104

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Activity measurement
In rats, activation of neuron spike activity dominated in the dorsal hippocampus in response to DSIP.
In plain wordsIn rats, DSIP mostly increased the electrical activity of neurons in the hippocampus.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseSpike activity in dorsal hippocampus
Study
ratn: not reported in source
Rats (cerebral ischemia after stress)
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The dorsal hippocampus was dominated by activation of spike activity in response to administration of delta sleep-inducing peptide
1 context sentence(design, population, supporting numbers)
Summary · context
The aims of the present work were to perform a comparative study of the effects of delta sleep-inducing peptide and Deltaran
Report a problemFND-1897510402

Studies that did not test the peptide alone3

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

02AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Activity measurement
In rats, DSIP and Deltaran activated spike activity in some neurons of the dorsal hippocampus, paraventricular hypothalamic nucleus and ventral anterior thalamic nuclei.
In plain wordsIn rats, DSIP and Deltaran increased the electrical activity of some neurons in three brain areas.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseNeuronal spike activity in emotiogenic brain structures
Study
ratn: not reported in source
Rats (cerebral ischemia after stress)
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
The results showed that Deltaran and delta sleep-inducing peptide had largely the same actions on the nature of spike activity of neurons in the dorsal hippocampus, paraventricular nucleus of the hypothalamus, and ventral anterior nuclei of the thalamus, evoking activation of some of the neurons in…
1 context sentence(design, population, supporting numbers)
Summary · context
The aims of the present work were to perform a comparative study of the effects of delta sleep-inducing peptide and Deltaran
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-1897510401
03AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In rats with cerebral ischemia, the index of brain blood supply was significantly greater in all animals given Deltaran than in animals not given Deltaran.
In plain wordsIn rats with brain ischemia, Deltaran raised brain blood supply compared with rats that did not receive it.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseIndex of brain blood supply (Deltaran)
Study
ratn: not reported in source
Rats (cerebral ischemia after stress)
Comparator
Animals not given Deltaran
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
In all animals given Deltaran, the index of brain blood supply was significantly greater than in animals not given Deltaran.
1 context sentence(design, population, supporting numbers)
Summary · context
The aims of the present work were to perform a comparative study of the effects of delta sleep-inducing peptide and Deltaran
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-1897510403
04AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome
In rats with cerebral ischemia, survival was 100% in animals given Deltaran; 38% of animals not given Deltaran died.
In plain wordsIn rats with brain ischemia, all animals given Deltaran survived, while 38% of those not given it died.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseSurvival of cerebral ischemia (Deltaran)
Study
ratn: not reported in source
Rats (cerebral ischemia after stress)
Comparator
Animals not given Deltaran
Outcome group
Mortality · Nervous system and cognition
Measurements
Survival rate
100%
Deltaran
Source sentences
Summary
The survival rate of cerebral ischemia was 100% in animals given Deltaran. Death occurred in 38% of animals not given Deltaran.
1 context sentence(design, population, supporting numbers)
Summary · context
The aims of the present work were to perform a comparative study of the effects of delta sleep-inducing peptide and Deltaran
In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).
Report a problemFND-1897510404

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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