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Study · Animal study (in vivo) · mouse · 2008

2 results

AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise.

Zwetsloot KA, Westerkamp LM, Holmes BF, Gavin TP

The Journal of physiology27 Oct 2008Cited by 62 (Europe PMC)

PMID18955383 (opens in a new tab)DOI10.1113/jphysiol.2008.159871 (opens in a new tab)PepBankPUB-18955383
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In wild-type mice, AICAR increased skeletal muscle VEGF mRNA.

    In plain wordsIn mice with normal AMPK, AICAR increased muscle VEGF mRNA levels.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseVEGF mRNA in wild-type mice
    Study

    mousen: not reported in source

    Skeletal muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    1.0 g kg(-1) · Two hoursAs given in this study (mouse).

    Source sentences

    Summary
    Two hours of the AMP analogue AICAR (1.0 g kg(-1)) or systemic hypoxia (6% O(2)) increased vascular endothelial growth factor (VEGF) mRNA in wild-type (WT), but not in AMPK DN mice.
    1 context sentence
    Summary · context
    Mice with muscle-specific inactive AMPK (AMPK DN) were used to investigate if AMPK regulates skeletal muscle capillarization and the angiogenic responses to exercise.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice with muscle-specific inactive AMPK, AICAR did not increase VEGF mRNA.

    In plain wordsIn mice with inactive muscle AMPK, AICAR did not increase muscle VEGF mRNA levels.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeVEGF mRNA in AMPK DN mice
    Study

    mousen: not reported in source

    Skeletal muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    1.0 g kg(-1) · Two hoursAs given in this study (mouse).

    Source sentences

    Summary
    Two hours of the AMP analogue AICAR (1.0 g kg(-1)) or systemic hypoxia (6% O(2)) increased vascular endothelial growth factor (VEGF) mRNA in wild-type (WT), but not in AMPK DN mice.
    1 context sentence
    Summary · context
    Mice with muscle-specific inactive AMPK (AMPK DN) were used to investigate if AMPK regulates skeletal muscle capillarization and the angiogenic responses to exercise.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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