Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes.

Vinogradova IA, Bukalev AV, Zabezhinski MA, Semenchenko AV, Khavinson VKh, Anisimov VN

Bulletin of experimental biology and medicine1 Dec 2007Cited by 6 (Europe PMC)

PMID18856211DOI10.1007/s10517-007-0441-zPepBankPUB-18856211

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In female rats under the standard day/night regimen, Epithalon did not change life span.
In plain wordsIn female rats on a normal day and night light cycle, Epithalon did not change life span.
Peptide
Epitalon
Outcome
No significant changeLife span under standard day/night regimen
Study
ratn: not reported in source
Female rats under standard, natural or constant illumination
Outcome group
Aging markers · Aging and longevity
Studied dose
0.1 microg daily 5 times a weekAs given in this study (rat).
Source sentences
Summary
did not change the life span of rats living under conditions of standard day/night regimen
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of Ala-Glu-Asp-Gly peptide (Epithalon) on the life span and development of spontaneous tumors were studied in female rats exposed to standard, natural for North-Western Russia, and constant illumination.
Report a problemFND-1885621101
02AnimalAnimal study (in vivo)Efficacy outcome
In female rats under natural illumination, Epithalon prolonged the maximum life span by 95 days.
In plain wordsIn female rats under natural light, Epithalon extended the maximum life span by 95 days.
Peptide
Epitalon
Outcome
IncreaseMaximum life span under natural illumination
Study
ratn: not reported in source
Female rats under standard, natural or constant illumination
Outcome group
Aging markers · Aging and longevity
Studied dose
0.1 microg daily 5 times a weekAs given in this study (rat).
Measurements
Maximum life span increase
95 days
natural illumination
Source sentences
Summary
while in rats exposed to the natural and constant light it promoted prolongation of the maximum life span by 95 and 24 days, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of Ala-Glu-Asp-Gly peptide (Epithalon) on the life span and development of spontaneous tumors were studied in female rats exposed to standard, natural for North-Western Russia, and constant illumination.
Report a problemFND-1885621102
03AnimalAnimal study (in vivo)Efficacy outcome
In female rats under constant illumination, Epithalon prolonged the maximum life span by 24 days.
In plain wordsIn female rats under constant light, Epithalon extended the maximum life span by 24 days.
Peptide
Epitalon
Outcome
IncreaseMaximum life span under constant illumination
Study
ratn: not reported in source
Female rats under standard, natural or constant illumination
Outcome group
Aging markers · Aging and longevity
Studied dose
0.1 microg daily 5 times a weekAs given in this study (rat).
Measurements
Maximum life span increase
24 days
constant illumination
Source sentences
Summary
while in rats exposed to the natural and constant light it promoted prolongation of the maximum life span by 95 and 24 days, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of Ala-Glu-Asp-Gly peptide (Epithalon) on the life span and development of spontaneous tumors were studied in female rats exposed to standard, natural for North-Western Russia, and constant illumination.
Report a problemFND-1885621103
04AnimalAnimal study (in vivo)Efficacy outcome
In female rats under natural illumination, Epithalon prolonged the mean life span of the last 10% of rats by 137 days.
In plain wordsIn female rats under natural light, Epithalon extended the mean life span of the longest-lived 10% by 137 days.
Peptide
Epitalon
Outcome
IncreaseMean life span of the last 10% of rats under natural illumination
Study
ratn: not reported in source
Female rats under standard, natural or constant illumination
Outcome group
Aging markers · Aging and longevity
Studied dose
0.1 microg daily 5 times a weekAs given in this study (rat).
Measurements
Mean life span increase, last 10%
137 days
natural illumination
Source sentences
Summary
Epithalon prolonged the mean life span of the last 10% of rats exposed to natural and constant illumination, treated with Epithalon, by 137 and 43 days, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of Ala-Glu-Asp-Gly peptide (Epithalon) on the life span and development of spontaneous tumors were studied in female rats exposed to standard, natural for North-Western Russia, and constant illumination.
Report a problemFND-1885621104
05AnimalAnimal study (in vivo)Efficacy outcome
In female rats under constant illumination, Epithalon prolonged the mean life span of the last 10% of rats by 43 days.
In plain wordsIn female rats under constant light, Epithalon extended the mean life span of the longest-lived 10% by 43 days.
Peptide
Epitalon
Outcome
IncreaseMean life span of the last 10% of rats under constant illumination
Study
ratn: not reported in source
Female rats under standard, natural or constant illumination
Outcome group
Aging markers · Aging and longevity
Studied dose
0.1 microg daily 5 times a weekAs given in this study (rat).
Measurements
Mean life span increase, last 10%
43 days
constant illumination
Source sentences
Summary
Epithalon prolonged the mean life span of the last 10% of rats exposed to natural and constant illumination, treated with Epithalon, by 137 and 43 days, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of Ala-Glu-Asp-Gly peptide (Epithalon) on the life span and development of spontaneous tumors were studied in female rats exposed to standard, natural for North-Western Russia, and constant illumination.
Report a problemFND-1885621105
06AnimalAnimal study (in vivo)Efficacy outcome
In female rats under natural light, Epithalon significantly inhibited the development of spontaneous tumors.
In plain wordsIn female rats under natural light, Epithalon significantly reduced the development of spontaneous tumors.
Peptide
Epitalon
Outcome
DecreaseSpontaneous tumor development under natural illumination
Study
ratn: not reported in source
Female rats under standard, natural or constant illumination
Outcome group
Tumor growth · Cancer
Studied dose
0.1 microg daily 5 times a weekAs given in this study (rat).
Source sentences
Summary
but significantly inhibited their development in rats exposed to natural light.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of Ala-Glu-Asp-Gly peptide (Epithalon) on the life span and development of spontaneous tumors were studied in female rats exposed to standard, natural for North-Western Russia, and constant illumination.
Report a problemFND-1885621106
07AnimalAnimal study (in vivo)Efficacy outcome
In female rats under standard or constant illumination, Epithalon had virtually no effect on the development of spontaneous tumors.
In plain wordsIn female rats under standard or constant light, Epithalon had virtually no effect on spontaneous tumor development.
Peptide
Epitalon
Outcome
No significant changeSpontaneous tumor development under standard and constant illumination
Study
ratn: not reported in source
Female rats under standard, natural or constant illumination
Outcome group
Tumor growth · Cancer
Studied dose
0.1 microg daily 5 times a weekAs given in this study (rat).
Source sentences
Summary
This peptide exhibited virtually no effect on the development of spontaneous tumors in rats exposed to standard and constant illumination
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of Ala-Glu-Asp-Gly peptide (Epithalon) on the life span and development of spontaneous tumors were studied in female rats exposed to standard, natural for North-Western Russia, and constant illumination.
Report a problemFND-1885621107

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

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