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Study · Randomized controlled trial · n = 104 · 2009

4 results

Does oxytocin influence the early detection of angry and happy faces?

Guastella AJ, Carson DS, Dadds MR, Mitchell PB, Cox RE

Psychoneuroendocrinology9 Oct 2008Cited by 87 (Europe PMC)

PMID18848401 (opens in a new tab)DOI10.1016/j.psyneuen.2008.09.001 (opens in a new tab)PepBankPUB-18848401
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, oxytocin did not change response time in detecting angry or happy faces versus placebo.

    In plain wordsIn healthy volunteers, oxytocin did not change how fast people found angry or happy faces compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeResponse time to angry and happy faces in visual search
    Study

    n = 104

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IUAs given in this study (human).

    Source sentences

    Summary
    Oxytocin did not, however, influence response time, accuracy, or gaze toward angry or happy faces, even when participants were separated into high- and low-social anxiety.
    1 context sentence
    Summary · context
    In a double-blind, randomized, placebo-controlled, between-subject design, oxytocin (24 IU) or a placebo was administered to 104 healthy volunteers.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, oxytocin did not change accuracy in detecting angry or happy faces versus placebo.

    In plain wordsIn healthy volunteers, oxytocin did not change how accurately people found angry or happy faces compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeAccuracy in detecting angry and happy faces
    Study

    n = 104

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IUAs given in this study (human).

    Source sentences

    Summary
    Oxytocin did not, however, influence response time, accuracy, or gaze toward angry or happy faces, even when participants were separated into high- and low-social anxiety.
    1 context sentence
    Summary · context
    In a double-blind, randomized, placebo-controlled, between-subject design, oxytocin (24 IU) or a placebo was administered to 104 healthy volunteers.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, oxytocin did not change gaze toward angry or happy faces versus placebo.

    In plain wordsIn healthy volunteers, oxytocin did not change where people looked, angry or happy faces, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeGaze toward angry and happy faces
    Study

    n = 104

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IUAs given in this study (human).

    Source sentences

    Summary
    Oxytocin did not, however, influence response time, accuracy, or gaze toward angry or happy faces, even when participants were separated into high- and low-social anxiety.
    1 context sentence
    Summary · context
    In a double-blind, randomized, placebo-controlled, between-subject design, oxytocin (24 IU) or a placebo was administered to 104 healthy volunteers.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers separated into high and low social anxiety, oxytocin did not influence detection of angry or happy faces versus placebo.

    In plain wordsIn healthy volunteers, oxytocin did not change face detection in people with high or low social anxiety, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeVisual search effects by social anxiety level
    Study

    n = 104

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    24 IUAs given in this study (human).

    Source sentences

    Summary
    Oxytocin did not, however, influence response time, accuracy, or gaze toward angry or happy faces, even when participants were separated into high- and low-social anxiety.
    1 context sentence
    Summary · context
    In a double-blind, randomized, placebo-controlled, between-subject design, oxytocin (24 IU) or a placebo was administered to 104 healthy volunteers.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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