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Study · Measured the body's own peptide · 2009

3 results

Muscle expressions of MGF, IGF-IEa, and myostatin in intact and hypophysectomized rats: effects of rhGH and testosterone alone or combined.

Rigamonti AE, Locatelli L, Cella SG, Bonomo SM, Giunta M, Molinari F, Sartorio A, Müller EE

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme7 Oct 2008Cited by 9 (Europe PMC)

PMID18841527 (opens in a new tab)DOI10.1055/s-0028-1087205 (opens in a new tab)PepBankPUB-18841527
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In hypophysectomized rats, rhGH treatment increased natural MGF mRNA expression in muscle.

    In plain wordsIn rats without a pituitary gland, growth hormone raised the body's own MGF mRNA in muscle.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMuscle MGF mRNA after rhGH in hypophysectomized rats
    Study

    ratn: not reported in source

    Intact and hypophysectomized rats, muscle MGF mRNA by RT-PCR
    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Administration of rhGH to hypophysectomized rats caused a marked increase in both MGF and IGF-IEa muscle mRNA levels
    1 context sentence
    Summary · context
    The aim of the present study was to investigate the effects of recombinant human growth hormone (rhGH) and/or testosterone on muscle MGF/IGF-IEa/myostatin expression in intact and hypophysectomized rats treated for 15 d with 1) saline or rhGH, 2) sesame oil or testosterone, 3) saline+sesame oil, or…

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In hypophysectomized rats, adding testosterone abolished the rhGH-induced rise in natural MGF mRNA in muscle.

    In plain wordsIn rats without a pituitary gland, adding testosterone removed the rise in the body's own MGF mRNA that growth hormone caused.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMuscle MGF mRNA after rhGH plus testosterone in hypophysectomized rats
    Study

    ratn: not reported in source

    Intact and hypophysectomized rats, muscle MGF mRNA by RT-PCR
    Comparator
    rhGH alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    an effect that was abolished when testosterone was combined with rhGH
    1 context sentence
    Summary · context
    The aim of the present study was to investigate the effects of recombinant human growth hormone (rhGH) and/or testosterone on muscle MGF/IGF-IEa/myostatin expression in intact and hypophysectomized rats treated for 15 d with 1) saline or rhGH, 2) sesame oil or testosterone, 3) saline+sesame oil, or…

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In intact rats, rhGH did not change natural MGF mRNA expression in muscle.

    In plain wordsIn normal rats, growth hormone did not change the body's own MGF mRNA in muscle.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeMuscle MGF mRNA after rhGH in intact rats
    Study

    ratn: not reported in source

    Intact and hypophysectomized rats, muscle MGF mRNA by RT-PCR
    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    in intact rats rhGH increased myostatin muscle mRNA levels without affecting those of MGF and IGF-IEa.
    1 context sentence
    Summary · context
    The aim of the present study was to investigate the effects of recombinant human growth hormone (rhGH) and/or testosterone on muscle MGF/IGF-IEa/myostatin expression in intact and hypophysectomized rats treated for 15 d with 1) saline or rhGH, 2) sesame oil or testosterone, 3) saline+sesame oil, or…

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:36 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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