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Study · In vitro (cells) · 2008

5 results

[Expression of mechano-growth factor in Escherichia coli and activity analysis].

Zhang B, Jiang P, Xian C, Li Y, Li D, Tang L, Wang Y

Sheng wu gong cheng xue bao = Chinese journal of biotechnology1 Jul 2008Cited by 4 (Europe PMC)

PMID18837392 (opens in a new tab)PepBankPUB-18837392
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In MC3T3-E1 cells, des(1‑3)IGF-1 promoted proliferation less than des(1‑3)MGF.

    In plain wordsIn cells, des(1‑3)IGF-1 promoted proliferation less than des(1‑3)MGF.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseCell proliferation
    Study

    n: not reported in source

    MC3T3-E1
    Comparator
    des(1-3)MGF
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results show that des(1-3)MGF exhibited more facilitative effects on proliferation and migration of MC3T3-E1 than that of des(1-3)IGF-1.
    1 context sentence
    Summary · context
    The purified des(1-3)MGF was incubated with MC3T3-E1 for cell proliferation and migration assays.
  2. 02LabIn vitro (cells)Activity measurement

    In MC3T3-E1 cells, des(1‑3)IGF-1 promoted migration less than des(1‑3)MGF.

    In plain wordsIn cells, des(1‑3)IGF-1 promoted migration less than des(1‑3)MGF.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseCell migration
    Study

    n: not reported in source

    MC3T3-E1
    Comparator
    des(1-3)MGF
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results show that des(1-3)MGF exhibited more facilitative effects on proliferation and migration of MC3T3-E1 than that of des(1-3)IGF-1.
    1 context sentence
    Summary · context
    The purified des(1-3)MGF was incubated with MC3T3-E1 for cell proliferation and migration assays.

Studies that did not test the peptide alone3

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

  1. 03LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Activity measurement

    In MC3T3-E1 cells, truncated des(1-3)MGF increased proliferation more than des(1-3)IGF-1.

    In plain wordsIn cells, a shortened form of MGF increased cell growth more than a shortened form of IGF-1.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseProliferation of MC3T3-E1 cells
    Study

    n: not reported in source

    MC3T3-E1 cells
    Comparator
    des(1-3)IGF-1
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    The purified des(1-3)MGF was incubated with MC3T3-E1 for cell proliferation and migration assays. The results show that des(1-3)MGF exhibited more facilitative effects on proliferation and migration of MC3T3-E1 than that of des(1-3)IGF-1.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  2. 04LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Activity measurement

    In MC3T3-E1 cells, truncated des(1-3)MGF increased migration more than des(1-3)IGF-1.

    In plain wordsIn cells, a shortened form of MGF increased cell movement more than a shortened form of IGF-1.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMigration of MC3T3-E1 cells
    Study

    n: not reported in source

    MC3T3-E1 cells
    Comparator
    des(1-3)IGF-1
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    The purified des(1-3)MGF was incubated with MC3T3-E1 for cell proliferation and migration assays. The results show that des(1-3)MGF exhibited more facilitative effects on proliferation and migration of MC3T3-E1 than that of des(1-3)IGF-1.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  3. 05LabNot a test of MGF / PEG-MGF aloneOther designOther

    Truncated des(1-3)MGF was produced in Escherichia coli and purified to 98% purity.

    In plain wordsIn lab work, a shortened form of MGF was made in bacteria and purified to 98% purity.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicablePurity of recombinant des(1-3)MGF
    Study

    n: not reported in source

    Recombinant expression in Escherichia coli
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Measurements

    Purity
    98%
    des(1-3)MGF

    Source sentences

    Summary
    After the fusion protein was cleaved by enterokinase, Trx and des(1-3)MGF was isolated by reverse-phase HPLC. Through these procedures, des(1-3) MGF was obtained with the purity of 98%.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 4Current

    21 Oct 2026, 13:52 UTC

    The same notice was added 2 times, first on 21 Oct 2026, 12:50 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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