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Study · Animal study (in vivo) · rat · 2008

1 result

[Formation of the spatial memory in rats with ischemic injury in prefrontal areas of the cortex--effects of a sinthetic analogue of ACTH(4-7)].

Silachev DN, Shram SI, Shakova FM, Romanova GA, Miasoedov NF

Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova1 Jul 2008Cited by 1 (Europe PMC)

PMID18825944 (opens in a new tab)PepBankPUB-18825944
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with photothrombotic prefrontal cortex injury, chronic intranasal Semax restored spatial learning ability.

    In plain wordsIn rats with brain injury in the prefrontal cortex, Semax given through the nose restored spatial learning ability.

    Peptide
    Semax
    Outcome
    IncreaseSpatial learning in Morris water maze after prefrontal cortex injury
    Study

    ratn: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    250 microg/kg · intranasal · six daysAs given in this study (rat).

    Source sentences

    Summary
    Chronic treatment of brain-injuried rats with peptide semax, a synthetic analogue of ACTH(4-7), at a dose of 250 microg/kg (intranasal, once a day) during six days after photothrombosis resulted in restoration of spatial learning ability.
    1 context sentence
    Summary · context
    Bilateral prefrontal cortex injury impair acquisition of the Morris water-maze on postoperative days 20-24.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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