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Study · Animal study (in vivo) · rat · 2009

2 results

Gastrin-releasing peptide messenger ribonucleic acid expression in the hypothalamic paraventricular nucleus is altered by melanocortin receptor stimulation and food deprivation.

Ladenheim EE, Behles RR, Bi S, Moran TH

Endocrinology25 Sept 2008Cited by 24 (Europe PMC)

PMID18818295 (opens in a new tab)PMCIDPMC2646528 (opens in a new tab)DOI10.1210/en.2008-0559 (opens in a new tab)PepBankPUB-18818295
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In ad libitum-fed rats, lateral ventricular MTII increased gastrin-releasing peptide mRNA expression in the paraventricular nucleus 4 h after administration.

    In plain wordsIn rats, MTII injected into the brain raised gastrin-releasing peptide gene activity in one brain region.

    Peptide
    Melanotan II
    Outcome
    IncreaseGRP mRNA expression in paraventricular nucleus in ad libitum-fed rats
    Study

    ratn: not reported in source

    in vivo, rats
    Outcome group
    Appetite and food intake · Nervous system and cognition
    Studied dose
    Dose not stated · lateral ventricular administration · 4 h after administrationAs given in this study (rat).

    Source sentences

    Summary
    lateral ventricular MTII administration increased GRP mRNA expression in ad libitum-fed rats 4 h after administration.
    1 context sentence
    Summary · context
    Because GRP neurons are localized in the vicinity of projection sites in the PVN for peptides that participate in energy homeostasis, we investigated whether GRP mRNA expression in the PVN may be sensitive to challenges imposed by either 38 h food deprivation or stimulation of the melanocortin syste…
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, MTII prevented the decrease in GRP mRNA expression seen in animals pair fed to the food consumed by MTII-injected animals.

    In plain wordsIn rats, MTII prevented the fall in gastrin-releasing peptide gene activity seen in pair-fed rats.

    Peptide
    Melanotan II
    Outcome
    IncreaseGRP mRNA expression in paraventricular nucleus versus pair-fed animals
    Study

    ratn: not reported in source

    in vivo, rats
    Comparator
    Pair-fed animals
    Outcome group
    Appetite and food intake · Nervous system and cognition
    Studied dose
    Dose not stated · lateral ventricular administrationAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, administration of MTII at a dose that reduces 24 h food intake and body weight prevented the decrease in GRP mRNA expression observed in animals that were pair fed to the amount of food consumed by those injected with MTII.
    1 context sentence
    Summary · context
    Because GRP neurons are localized in the vicinity of projection sites in the PVN for peptides that participate in energy homeostasis, we investigated whether GRP mRNA expression in the PVN may be sensitive to challenges imposed by either 38 h food deprivation or stimulation of the melanocortin syste…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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