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Study · Randomized controlled trial · n = 29 · 2009

4 results

Oxytocin enhances processing of positive versus negative emotional information in healthy male volunteers.

Di Simplicio M, Massey-Chase R, Cowen PJ, Harmer CJ

Journal of psychopharmacology (Oxford, England)18 Sept 2008Cited by 168 (Europe PMC)

PMID18801829 (opens in a new tab)DOI10.1177/0269881108095705 (opens in a new tab)PepBankPUB-18801829
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy men, a single intranasal oxytocin dose slowed reaction time to correctly identify fearful faces versus placebo.

    In plain wordsIn healthy men, one dose of oxytocin nasal spray slowed the time to recognise fearful faces compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseReaction time to identify fearful facial expressions
    Study

    n = 29

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 UI · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    A single dose of intranasally administered oxytocin slowed reaction time to correctly identify fearful facial expressions and reduced the misclassification of positive emotions as negative ones.
    1 context sentence
    Summary · context
    Twenty-nine male healthy volunteers were randomly allocated to receive a single dose of oxytocin nasal spray (24 UI) or placebo.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy men, a single intranasal oxytocin dose reduced the misclassification of positive emotions as negative ones versus placebo.

    In plain wordsIn healthy men, one dose of oxytocin nasal spray reduced mistaking positive expressions for negative ones, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseMisclassification of positive emotions as negative
    Study

    n = 29

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 UI · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    A single dose of intranasally administered oxytocin slowed reaction time to correctly identify fearful facial expressions and reduced the misclassification of positive emotions as negative ones.
    1 context sentence
    Summary · context
    Twenty-nine male healthy volunteers were randomly allocated to receive a single dose of oxytocin nasal spray (24 UI) or placebo.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy men, intranasal oxytocin did not change subjective mood ratings versus placebo.

    In plain wordsIn healthy men, oxytocin nasal spray did not change self-rated mood compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeSubjective mood rating
    Study

    n = 29

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    24 UI · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    These effects occurred in the absence of significant differences in subjective ratings of mood and anxiety.
    1 context sentence
    Summary · context
    Twenty-nine male healthy volunteers were randomly allocated to receive a single dose of oxytocin nasal spray (24 UI) or placebo.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In healthy men, intranasal oxytocin did not change subjective anxiety ratings versus placebo.

    In plain wordsIn healthy men, oxytocin nasal spray did not change self-rated anxiety compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeSubjective anxiety rating
    Study

    n = 29

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    24 UI · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    These effects occurred in the absence of significant differences in subjective ratings of mood and anxiety.
    1 context sentence
    Summary · context
    Twenty-nine male healthy volunteers were randomly allocated to receive a single dose of oxytocin nasal spray (24 UI) or placebo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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