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Study · Measured the body's own peptide · 2008

2 results

Growth hormone stimulates mechano growth factor expression and activates myoblast transformation in C2C12 cells.

Imanaka M, Iida K, Murawaki A, Nishizawa H, Fukuoka H, Takeno R, Takahashi Y, Okimura Y, Kaji H, Chihara K

The Kobe journal of medical sciences23 May 2008Cited by 12 (Europe PMC)

PMID18772608 (opens in a new tab)PepBankPUB-18772608
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Mechanism

    In C2C12 mouse muscle cells, MGF mRNA increased 1 h after growth hormone stimulation, earlier than IGF-IEa mRNA, which increased 4 h after.

    In plain wordsIn mouse muscle cells, growth hormone raised the cells' own MGF production within 1 hour.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF mRNA after growth hormone stimulation
    Study

    mousen: not reported in source

    C2C12 mouse muscle cell line
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    The MGF mRNA increased 1 h following GH stimulation whereas IGF-IEa mRNA, which encodes a systemic type of IGF-I, increased 4 h following GH stimulation.
    1 context sentence
    Summary · context
    In the present study, we examined the effect of growth hormone (GH) on MGF expression in C2C12 mouse muscle cell lines since GH is the principal regulator of IGF-I.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Mechanism

    In C2C12 mouse muscle cells, muscle injury induced with bupivacaine produced the same diverse expression of MGF and IGF-IEa that was seen after growth hormone stimulation.

    In plain wordsIn mouse muscle cells, injury with bupivacaine showed the same difference between the cells' own MGF and IGF-IEa expression as growth hormone did.

    Peptide
    MGF / PEG-MGF
    Outcome
    Direction not reportedMGF and IGF-IEa expression after bupivacaine injury in C2C12 cells
    Study

    mousen: not reported in source

    C2C12 mouse muscle cell line
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    The diverse expression of MGF and IGF-IEa was also observed in the case of muscle injury by using bupivacaine in the same cell line.
    1 context sentence
    Summary · context
    In the present study, we examined the effect of growth hormone (GH) on MGF expression in C2C12 mouse muscle cell lines since GH is the principal regulator of IGF-I.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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