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Study · Animal study (in vivo) · rat · 2008

8 results

Differential effects of intermittent PTH(1-34) and PTH(7-34) on bone microarchitecture and aortic calcification in experimental renal failure.

Sebastian EM, Suva LJ, Friedman PA

Bone9 Aug 2008Cited by 39 (Europe PMC)

PMID18761112 (opens in a new tab)PMCIDPMC2644420 (opens in a new tab)DOI10.1016/j.bone.2008.07.250 (opens in a new tab)PepBankPUB-18761112
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In parathyroidectomized rats, PTH(1-34) had a greater hypercalcemic effect than PTH(7-34).

    In plain wordsIn rats with removed parathyroid glands, PTH(1-34) raised blood calcium more than PTH(7-34).

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseHypercalcemic effect
    Study

    ratn: not reported in source

    Experimental CKD with or without parathyroidectomy
    Comparator
    PTH(7-34)
    Outcome group
    Adverse events · Endocrine and hormones
    Studied dose
    40 microg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    PTH(1-34) was more hypercalcemic than PTH(7-34) in PTX rats.
    2 context sentences
    Summary · context
    Here, we examined the effects of intermittent administration of PTH(1-34) and PTH(7-34) on mineral ion metabolism, bone architecture, and vascular calcification in rats with experimental CKD. CKD with or without parathyroidectomy (PTX) was established by 5/6 nephrectomy (NPX) in rats.
    Summary · context
    Rats were treated with single daily doses of 40 microg/kg PTH(1-34), PTH(7-34), or vehicle.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH(1-34) increased fractional bone volume versus vehicle in all surgical groups.

    In plain wordsIn rats, PTH(1-34) increased bone volume fraction compared with vehicle in all surgical groups.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseFractional bone volume
    Study

    ratn: not reported in source

    Experimental CKD with or without parathyroidectomy
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 microg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    Fractional bone volume in rats treated with PTH(1-34) increased significantly in all groups compared to that of vehicle treatment.
    2 context sentences
    Summary · context
    Here, we examined the effects of intermittent administration of PTH(1-34) and PTH(7-34) on mineral ion metabolism, bone architecture, and vascular calcification in rats with experimental CKD. CKD with or without parathyroidectomy (PTX) was established by 5/6 nephrectomy (NPX) in rats.
    Summary · context
    Rats were treated with single daily doses of 40 microg/kg PTH(1-34), PTH(7-34), or vehicle.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH(1-34) increased trabecular number.

    In plain wordsIn rats, PTH(1-34) increased the number of bone trabeculae.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseTrabecular number
    Study

    ratn: not reported in source

    Experimental CKD with or without parathyroidectomy
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 microg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    In addition, trabecular number, thickness and volumetric bone density increased in rats treated with PTH(1-34).
    2 context sentences
    Summary · context
    Here, we examined the effects of intermittent administration of PTH(1-34) and PTH(7-34) on mineral ion metabolism, bone architecture, and vascular calcification in rats with experimental CKD. CKD with or without parathyroidectomy (PTX) was established by 5/6 nephrectomy (NPX) in rats.
    Summary · context
    Rats were treated with single daily doses of 40 microg/kg PTH(1-34), PTH(7-34), or vehicle.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH(1-34) increased trabecular thickness.

    In plain wordsIn rats, PTH(1-34) increased bone trabecular thickness.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseTrabecular thickness
    Study

    ratn: not reported in source

    Experimental CKD with or without parathyroidectomy
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 microg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    In addition, trabecular number, thickness and volumetric bone density increased in rats treated with PTH(1-34).
    2 context sentences
    Summary · context
    Here, we examined the effects of intermittent administration of PTH(1-34) and PTH(7-34) on mineral ion metabolism, bone architecture, and vascular calcification in rats with experimental CKD. CKD with or without parathyroidectomy (PTX) was established by 5/6 nephrectomy (NPX) in rats.
    Summary · context
    Rats were treated with single daily doses of 40 microg/kg PTH(1-34), PTH(7-34), or vehicle.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH(1-34) increased volumetric bone density.

    In plain wordsIn rats, PTH(1-34) increased volumetric bone density.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseVolumetric bone density
    Study

    ratn: not reported in source

    Experimental CKD with or without parathyroidectomy
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 microg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    In addition, trabecular number, thickness and volumetric bone density increased in rats treated with PTH(1-34).
    2 context sentences
    Summary · context
    Here, we examined the effects of intermittent administration of PTH(1-34) and PTH(7-34) on mineral ion metabolism, bone architecture, and vascular calcification in rats with experimental CKD. CKD with or without parathyroidectomy (PTX) was established by 5/6 nephrectomy (NPX) in rats.
    Summary · context
    Rats were treated with single daily doses of 40 microg/kg PTH(1-34), PTH(7-34), or vehicle.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with experimental renal failure, PTH(1-34) diminished vascular calcification.

    In plain wordsIn rats with experimental kidney failure, PTH(1-34) reduced calcium deposits in blood vessels.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseVascular calcification
    Study

    ratn: not reported in source

    Experimental CKD with or without parathyroidectomy
    Outcome group
    Tissue calcification · Cardiovascular
    Studied dose
    40 microg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    In contrast, PTH(1-34) diminished vascular calcification.
    2 context sentences
    Summary · context
    Here, we examined the effects of intermittent administration of PTH(1-34) and PTH(7-34) on mineral ion metabolism, bone architecture, and vascular calcification in rats with experimental CKD. CKD with or without parathyroidectomy (PTX) was established by 5/6 nephrectomy (NPX) in rats.
    Summary · context
    Rats were treated with single daily doses of 40 microg/kg PTH(1-34), PTH(7-34), or vehicle.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats, renal PTH1R mRNA increased in response to PTH(1-34).

    In plain wordsIn rats, PTH(1-34) increased kidney PTH receptor gene expression.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseRenal PTH1R mRNA
    Study

    ratn: not reported in source

    Experimental CKD with or without parathyroidectomy
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    40 microg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    Renal but not bone PTH1R mRNA increased in response to PTH(1-34).
    2 context sentences
    Summary · context
    Here, we examined the effects of intermittent administration of PTH(1-34) and PTH(7-34) on mineral ion metabolism, bone architecture, and vascular calcification in rats with experimental CKD. CKD with or without parathyroidectomy (PTX) was established by 5/6 nephrectomy (NPX) in rats.
    Summary · context
    Rats were treated with single daily doses of 40 microg/kg PTH(1-34), PTH(7-34), or vehicle.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats, bone PTH1R mRNA did not increase in response to PTH(1-34).

    In plain wordsIn rats, PTH(1-34) did not increase bone PTH receptor gene expression.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeBone PTH1R mRNA
    Study

    ratn: not reported in source

    Experimental CKD with or without parathyroidectomy
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    40 microg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    Renal but not bone PTH1R mRNA increased in response to PTH(1-34).
    2 context sentences
    Summary · context
    Here, we examined the effects of intermittent administration of PTH(1-34) and PTH(7-34) on mineral ion metabolism, bone architecture, and vascular calcification in rats with experimental CKD. CKD with or without parathyroidectomy (PTX) was established by 5/6 nephrectomy (NPX) in rats.
    Summary · context
    Rats were treated with single daily doses of 40 microg/kg PTH(1-34), PTH(7-34), or vehicle.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:37 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    22 Oct 2026, 02:26 UTC

    Study results updated

  3. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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