[Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex].

Agapova TIu, Agniullin IaV, Silachev DN, Shadrina MI, Slominskiĭ PA, Shram SI, Limborskaia SA, Miasoedov NF

Molekuliarnaia genetika, mikrobiologiia i virusologiia1 Jan 2008Cited by 1 (Europe PMC)

PMID18756821PepBankPUB-18756821

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats, a single intranasal dose of Semax decreased Bdnf gene expression in the hippocampus at 20 minutes.
In plain wordsIn rats, a single nasal dose of Semax lowered Bdnf gene activity in the hippocampus after 20 minutes.
Peptide
Semax
Outcome
DecreaseBdnf expression in hippocampus at 20 minutes
Study
ratn: not reported in source
Outcome group
Neurotransmitters and neurotrophic factors · Nervous system and cognition
Studied dose
50 mg/kg · intranasal · single administrationAs given in this study (rat).
Source sentences
Summary
It was shown that the studied gene expression levels changed significantly both in the hippocampus and the frontal cortex tissues 20 minutes after the peptide preparation application. The expression levels decreased in the hippocampus and increased in the frontal cortex.
1 context sentence(design, population, supporting numbers)
Summary · context
Temporary dynamics of Bdnf and Ngf ex- pression in rat hippocampus and frontal cortex under Semax action (50 mg/kg, single intranasal administration) was studied in this work.
Report a problemFND-1875682101
02AnimalAnimal study (in vivo)Mechanism
In rats, a single intranasal dose of Semax decreased Ngf gene expression in the hippocampus at 20 minutes.
In plain wordsIn rats, a single nasal dose of Semax lowered Ngf gene activity in the hippocampus after 20 minutes.
Peptide
Semax
Outcome
DecreaseNgf expression in hippocampus at 20 minutes
Study
ratn: not reported in source
Outcome group
Neurotransmitters and neurotrophic factors · Nervous system and cognition
Studied dose
50 mg/kg · intranasal · single administrationAs given in this study (rat).
Source sentences
Summary
It was shown that the studied gene expression levels changed significantly both in the hippocampus and the frontal cortex tissues 20 minutes after the peptide preparation application. The expression levels decreased in the hippocampus and increased in the frontal cortex.
1 context sentence(design, population, supporting numbers)
Summary · context
Temporary dynamics of Bdnf and Ngf ex- pression in rat hippocampus and frontal cortex under Semax action (50 mg/kg, single intranasal administration) was studied in this work.
Report a problemFND-1875682102
03AnimalAnimal study (in vivo)Mechanism
In rats, a single intranasal dose of Semax increased Bdnf gene expression in the frontal cortex at 20 minutes.
In plain wordsIn rats, a single nasal dose of Semax raised Bdnf gene activity in the frontal cortex after 20 minutes.
Peptide
Semax
Outcome
IncreaseBdnf expression in frontal cortex at 20 minutes
Study
ratn: not reported in source
Outcome group
Neurotransmitters and neurotrophic factors · Nervous system and cognition
Studied dose
50 mg/kg · intranasal · single administrationAs given in this study (rat).
Source sentences
Summary
It was shown that the studied gene expression levels changed significantly both in the hippocampus and the frontal cortex tissues 20 minutes after the peptide preparation application. The expression levels decreased in the hippocampus and increased in the frontal cortex.
1 context sentence(design, population, supporting numbers)
Summary · context
Temporary dynamics of Bdnf and Ngf ex- pression in rat hippocampus and frontal cortex under Semax action (50 mg/kg, single intranasal administration) was studied in this work.
Report a problemFND-1875682103
04AnimalAnimal study (in vivo)Mechanism
In rats, a single intranasal dose of Semax increased Ngf gene expression in the frontal cortex at 20 minutes.
In plain wordsIn rats, a single nasal dose of Semax raised Ngf gene activity in the frontal cortex after 20 minutes.
Peptide
Semax
Outcome
IncreaseNgf expression in frontal cortex at 20 minutes
Study
ratn: not reported in source
Outcome group
Neurotransmitters and neurotrophic factors · Nervous system and cognition
Studied dose
50 mg/kg · intranasal · single administrationAs given in this study (rat).
Source sentences
Summary
It was shown that the studied gene expression levels changed significantly both in the hippocampus and the frontal cortex tissues 20 minutes after the peptide preparation application. The expression levels decreased in the hippocampus and increased in the frontal cortex.
1 context sentence(design, population, supporting numbers)
Summary · context
Temporary dynamics of Bdnf and Ngf ex- pression in rat hippocampus and frontal cortex under Semax action (50 mg/kg, single intranasal administration) was studied in this work.
Report a problemFND-1875682104
05AnimalAnimal study (in vivo)Mechanism
In rats, Bdnf expression had returned to control tissue levels forty minutes after intranasal Semax.
In plain wordsIn rats, Bdnf gene activity was back to the level of control tissue forty minutes after Semax.
Peptide
Semax
Outcome
No significant changeBdnf expression at forty minutes
Study
ratn: not reported in source
Comparator
Control tissues
Outcome group
Neurotransmitters and neurotrophic factors · Nervous system and cognition
Studied dose
50 mg/kg · intranasal · single administrationAs given in this study (rat).
Source sentences
Summary
Forty minutes after Semax administration both gene expression levels returned to the level typical of control tissues.
1 context sentence(design, population, supporting numbers)
Summary · context
Temporary dynamics of Bdnf and Ngf ex- pression in rat hippocampus and frontal cortex under Semax action (50 mg/kg, single intranasal administration) was studied in this work.
Report a problemFND-1875682105
06AnimalAnimal study (in vivo)Mechanism
In rats, Ngf expression had returned to control tissue levels forty minutes after intranasal Semax.
In plain wordsIn rats, Ngf gene activity was back to the level of control tissue forty minutes after Semax.
Peptide
Semax
Outcome
No significant changeNgf expression at forty minutes
Study
ratn: not reported in source
Comparator
Control tissues
Outcome group
Neurotransmitters and neurotrophic factors · Nervous system and cognition
Studied dose
50 mg/kg · intranasal · single administrationAs given in this study (rat).
Source sentences
Summary
Forty minutes after Semax administration both gene expression levels returned to the level typical of control tissues.
1 context sentence(design, population, supporting numbers)
Summary · context
Temporary dynamics of Bdnf and Ngf ex- pression in rat hippocampus and frontal cortex under Semax action (50 mg/kg, single intranasal administration) was studied in this work.
Report a problemFND-1875682106
07AnimalAnimal study (in vivo)Mechanism
In rats, Bdnf expression increased significantly by 90 minutes after intranasal Semax.
In plain wordsIn rats, Bdnf gene activity rose significantly by 90 minutes after Semax.
Peptide
Semax
Outcome
IncreaseBdnf expression at 90 minutes
Study
ratn: not reported in source
Outcome group
Neurotransmitters and neurotrophic factors · Nervous system and cognition
Studied dose
50 mg/kg · intranasal · single administrationAs given in this study (rat).
Source sentences
Summary
After that they increased significantly by 90 minutes after experiment start.
1 context sentence(design, population, supporting numbers)
Summary · context
Temporary dynamics of Bdnf and Ngf ex- pression in rat hippocampus and frontal cortex under Semax action (50 mg/kg, single intranasal administration) was studied in this work.
Report a problemFND-1875682107
08AnimalAnimal study (in vivo)Mechanism
In rats, Ngf expression increased significantly by 90 minutes after intranasal Semax.
In plain wordsIn rats, Ngf gene activity rose significantly by 90 minutes after Semax.
Peptide
Semax
Outcome
IncreaseNgf expression at 90 minutes
Study
ratn: not reported in source
Outcome group
Neurotransmitters and neurotrophic factors · Nervous system and cognition
Studied dose
50 mg/kg · intranasal · single administrationAs given in this study (rat).
Source sentences
Summary
After that they increased significantly by 90 minutes after experiment start.
1 context sentence(design, population, supporting numbers)
Summary · context
Temporary dynamics of Bdnf and Ngf ex- pression in rat hippocampus and frontal cortex under Semax action (50 mg/kg, single intranasal administration) was studied in this work.
Report a problemFND-1875682108
09AnimalAnimal study (in vivo)Mechanism
In rats, Bdnf expression fell back to control levels by 8 hours after intranasal Semax, after reaching its maximum.
In plain wordsIn rats, Bdnf gene activity fell back to control levels by 8 hours after Semax.
Peptide
Semax
Outcome
No significant changeBdnf expression at 8 hours
Study
ratn: not reported in source
Comparator
Control levels
Outcome group
Neurotransmitters and neurotrophic factors · Nervous system and cognition
Studied dose
50 mg/kg · intranasal · single administrationAs given in this study (rat).
Source sentences
Summary
Bdnf and Ngf expression levels decreased up to the control levels by 8 hours after medicine applying maximum gene expression levels were attained.
1 context sentence(design, population, supporting numbers)
Summary · context
Temporary dynamics of Bdnf and Ngf ex- pression in rat hippocampus and frontal cortex under Semax action (50 mg/kg, single intranasal administration) was studied in this work.
Report a problemFND-1875682109
10AnimalAnimal study (in vivo)Mechanism
In rats, Ngf expression fell back to control levels by 8 hours after intranasal Semax, after reaching its maximum.
In plain wordsIn rats, Ngf gene activity fell back to control levels by 8 hours after Semax.
Peptide
Semax
Outcome
No significant changeNgf expression at 8 hours
Study
ratn: not reported in source
Comparator
Control levels
Outcome group
Neurotransmitters and neurotrophic factors · Nervous system and cognition
Studied dose
50 mg/kg · intranasal · single administrationAs given in this study (rat).
Source sentences
Summary
Bdnf and Ngf expression levels decreased up to the control levels by 8 hours after medicine applying maximum gene expression levels were attained.
1 context sentence(design, population, supporting numbers)
Summary · context
Temporary dynamics of Bdnf and Ngf ex- pression in rat hippocampus and frontal cortex under Semax action (50 mg/kg, single intranasal administration) was studied in this work.
Report a problemFND-1875682110

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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