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Study · Measured the body's own peptide · 2008

3 results

Hyperthermia and acidification stimulate mechano-growth factor synthesis in murine myoblasts and myotubes.

Kravchenko IV, Furalyov VA, Popov VO

Biochemical and biophysical research communications13 Aug 2008Cited by 6 (Europe PMC)

PMID18706390 (opens in a new tab)DOI10.1016/j.bbrc.2008.08.016 (opens in a new tab)PepBankPUB-18706390
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Mechanism

    In murine myoblasts and myotubes, hyperthermia stimulated MGF expression, with a peak at 40 degrees.

    In plain wordsIn mouse muscle cells, heat raised the cells' own MGF production.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF expression under hyperthermia
    Study

    mousen: not reported in source

    Murine primary myoblasts and differentiated myotubes in culture
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    Hyperthermia was shown to stimulate MGF expression both in primary myoblasts and in differentiated multinuclear myotubes. The induction of MGF synthesis peaked at 40 degrees capital ES, Cyrillic, with some activation at 39 and 41 degrees capital ES, Cyrillic.
    1 context sentence
    Summary · context
    The effect of cellular stress factors, the hyperthermia and the acidification of culture medium, on mechano-growth factor (MGF) synthesis by murine myoblasts in culture was investigated.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Mechanism

    In murine myoblasts, lowering the culture medium pH stimulated MGF expression, with a maximum at pH 6.3.

    In plain wordsIn mouse muscle cells, more acidic medium raised the cells' own MGF production.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF expression under acidification
    Study

    mousen: not reported in source

    Murine primary myoblasts and differentiated myotubes in culture
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Measurements

    pH at maximum MGF expression
    6.3 pH
    acidification

    Source sentences

    Summary
    Decrease of culture medium pH stimulated MGF expression with a maximum at pH 6.3.
    1 context sentence
    Summary · context
    The effect of cellular stress factors, the hyperthermia and the acidification of culture medium, on mechano-growth factor (MGF) synthesis by murine myoblasts in culture was investigated.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Mechanism

    In murine myoblasts, hydrocortisone completely eliminated the induction of MGF synthesis under hyperthermia and acidification.

    In plain wordsIn mouse muscle cells, hydrocortisone stopped the heat and acid induced rise in the cells' own MGF production.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseEffect of hydrocortisone on stress-induced MGF synthesis
    Study

    mousen: not reported in source

    Murine primary myoblasts and differentiated myotubes in culture
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    Hydrocortisone eliminated induction of MGF synthesis completely both under hyperthermia and acidification conditions.
    1 context sentence
    Summary · context
    The effect of cellular stress factors, the hyperthermia and the acidification of culture medium, on mechano-growth factor (MGF) synthesis by murine myoblasts in culture was investigated.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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