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Study · Animal study (in vivo) · rat · 2008

2 results

[A comparative analysis of distribution of glyprolines administered by various routes].

Ashmarin IP, Baglikova KE, Edeeva SE, Zolotarev IuA, Kozik VS, Dadaian AK, Dorokhova EM, Alfeeva LIu, Andreeva LA, Kopylova GN, Pavlov TS, Vas'kovskiĭ BV and 6 more

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Meshavkin VK, Sokolov OIu, Kost NV, Zozulia AA, Samonina GE, Miasoedov NF

Bioorganicheskaia khimiia1 Jul 2008Cited by 3 (Europe PMC)

PMID18695718 (opens in a new tab)DOI10.1134/s1068162008040043 (opens in a new tab)PepBankPUB-18695718
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, intranasal administration of Selanc was optimal for delivery to the central nervous system.

    In plain wordsIn rats, giving selank through the nose was the best route to get it into the central nervous system.

    Peptide
    Selank
    Outcome
    Not applicableCNS delivery by intranasal administration
    Study

    ratn: not reported in source

    Rat organs, tritium-labelled peptides
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intranasalAs given in this study (rat).

    Source sentences

    Summary
    The intranasal administration of both peptides was shown to be optimal for the delivery of glyproline molecules in the CNS.
    1 context sentence
    Summary · context
    The distribution of the glyprolines Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selanc) was analyzed and compared in tissues of rat organs after different ways of their administration using the peptides uniformly labeled with tritium.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, Selanc showed high affinity for gastric tissues after every route of administration.

    In plain wordsIn rats, selank built up in stomach tissue after every route of administration.

    Peptide
    Selank
    Outcome
    Not applicableGastric tissue affinity and accumulation
    Study

    ratn: not reported in source

    Rat organs, tritium-labelled peptides
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intraperitoneal, intranasal, intragastric and intravenousAs given in this study (rat).

    Source sentences

    Summary
    Comparative data on changes in concentrations of the peptides in the rat organs after their intraperitoneal, intranasal, intragastric, and intravenous administration are given.
    2 context sentences
    Summary · context
    A high affinity of the studied glyprolines for gastric tissues was found for all the ways of their administration.
    Summary · context
    The distribution of the glyprolines Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selanc) was analyzed and compared in tissues of rat organs after different ways of their administration using the peptides uniformly labeled with tritium.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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