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Study · In vitro (cells) · mouse · 2008

4 results

Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cells.

Peng Y, Chen Z, Yu W, Zhou Q, Xu L, Mao FF, Huang G, Zhang X, Li S, Lahn BT, Xiang AP

Cell biology international23 Jul 2008Cited by 16 (Europe PMC)

PMID18692582 (opens in a new tab)DOI10.1016/j.cellbi.2008.07.011 (opens in a new tab)PepBankPUB-18692582
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In mouse embryonic stem cells, thymosin alpha‑1 induced differentiation into CD3+ T cells.

    In plain wordsIn mouse stem cells in the lab, thymosin alpha‑1 pushed the cells to become CD3+ T cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseDifferentiation of ES cells into CD3+ T cells
    Study

    mousen: not reported in source

    Mouse embryonic stem cells (embryoid body induction)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Using the embryoid body induction system, we found that both Talpha-1 and thymopeptides effectively induced ES cells to differentiate sequentially into the CD3+ and CD4+/CD8+ T cells.
    1 context sentence
    Summary · context
    In this paper, we compared the effects of three thymic polypeptides, thymopentin (TP5), thymosin alpha-1 (Talpha-1) and thymopeptides on the in vitro thymopoiesis of mouse embryonic stem (ES) cells.
  2. 02LabIn vitro (cells)Activity measurement

    In mouse embryonic stem cells, thymosin alpha‑1 induced differentiation into CD4+/CD8+ T cells.

    In plain wordsIn mouse stem cells in the lab, thymosin alpha‑1 pushed the cells to become CD4+/CD8+ T cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseDifferentiation of ES cells into CD4+/CD8+ T cells
    Study

    mousen: not reported in source

    Mouse embryonic stem cells (embryoid body induction)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Using the embryoid body induction system, we found that both Talpha-1 and thymopeptides effectively induced ES cells to differentiate sequentially into the CD3+ and CD4+/CD8+ T cells.
    1 context sentence
    Summary · context
    In this paper, we compared the effects of three thymic polypeptides, thymopentin (TP5), thymosin alpha-1 (Talpha-1) and thymopeptides on the in vitro thymopoiesis of mouse embryonic stem (ES) cells.
  3. 03LabIn vitro (cells)Mechanism

    In mouse embryonic stem cells induced with thymosin alpha‑1 and thymopeptides, the T cells had TCR Vbeta gene rearrangement, and most were TCR alphabeta T cells.

    In plain wordsIn mouse stem cells in the lab, the T cells made with thymosin alpha‑1 and thymopeptides showed TCR gene rearrangement.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableTCR Vbeta gene rearrangement in induced T cells
    Study

    mousen: not reported in source

    Mouse embryonic stem cells (embryoid body induction)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Using the embryoid body induction system, we found that both Talpha-1 and thymopeptides effectively induced ES cells to differentiate sequentially into the CD3+ and CD4+/CD8+ T cells. These T cells had T cell receptor (TCR) Vbeta gene rearrangement and most were TCRalphabeta T cells.
    1 context sentence
    Summary · context
    In this paper, we compared the effects of three thymic polypeptides, thymopentin (TP5), thymosin alpha-1 (Talpha-1) and thymopeptides on the in vitro thymopoiesis of mouse embryonic stem (ES) cells.
  4. 04LabIn vitro (cells)Mechanism

    In the mouse embryonic stem cell induction system, expression of Notch and its ligands Delta-like-1 and Delta-like-4 gradually increased during induction.

    In plain wordsIn mouse stem cells in the lab, Notch signalling genes rose step by step during T cell induction.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseNotch receptor and ligand expression during induction
    Study

    mousen: not reported in source

    Mouse embryonic stem cells (embryoid body induction)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We also found that the expression of the Notch receptor and its ligands Delta-like-1 and Delta-like-4 gradually increased during the induction.
    1 context sentence
    Summary · context
    In this paper, we compared the effects of three thymic polypeptides, thymopentin (TP5), thymosin alpha-1 (Talpha-1) and thymopeptides on the in vitro thymopoiesis of mouse embryonic stem (ES) cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

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