In adult Wistar rats with early-life catecholaminergic damage from 6-hydroxydopamine, Selank restored cognitive processes.
In plain wordsIn rats with early-life damage to a brain signalling system, Selank restored thinking and learning functions.
- Peptide
- Selank
- Outcome
- IncreaseCognitive processes after catecholamine system damage
- Study
ratn: not reported in source
neonatal 6-hydroxydopamine catecholamine damage- Outcome group
- Cognition and memory · Nervous system and cognition
- Studied dose
- 300 microg/kgAs given in this study (rat).
Source sentences
Selank (300 microg/kg) restored cognitive processes disordered by chronic artificial inhibition of the cerebral catecholaminergic system.
1 context sentence(design, population, supporting numbers)
Effects of selank on learning, memory, and attention to sensory stimuli of different modality were studied in adult Wistar rats treated with 6-hydroxydopamine (neurotoxin selectively damaging catecholaminergic neurons and their terminals) during the first 3 days of life.