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Study · Animal study (in vivo) · mouse · 2008

2 results

AMPK and PPARdelta agonists are exercise mimetics.

Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, Kang H, Shaw RJ, Evans RM

Cell31 Jul 2008Cited by 975 (Europe PMC)

PMID18674809 (opens in a new tab)PMCIDPMC2706130 (opens in a new tab)DOI10.1016/j.cell.2008.06.051 (opens in a new tab)PepBankPUB-18674809
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In sedentary mice, AICAR treatment alone induced metabolic genes.

    In plain wordsIn sedentary mice, AICAR alone increased metabolic gene activity.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseMetabolic gene induction
    Study

    mousen: not reported in source

    sedentary mice
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Unexpectedly, even in sedentary mice, 4 weeks of AICAR treatment alone induced metabolic genes and enhanced running endurance by 44%.
    1 context sentence
    Summary · context
    We therefore tested the effect of pathway-specific drugs on endurance capacities of mice in a treadmill running test.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In sedentary mice, AICAR treatment alone enhanced running endurance by 44%.

    In plain wordsIn sedentary mice, AICAR alone increased running endurance by 44%.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseRunning endurance
    Study

    mousen: not reported in source

    sedentary mice
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated · 4 weeksAs given in this study (mouse).

    Measurements

    Running endurance increase
    44%
    sedentary mice

    Source sentences

    Summary
    Unexpectedly, even in sedentary mice, 4 weeks of AICAR treatment alone induced metabolic genes and enhanced running endurance by 44%.
    1 context sentence
    Summary · context
    We therefore tested the effect of pathway-specific drugs on endurance capacities of mice in a treadmill running test.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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