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Study · Animal study (in vivo) · mouse and rat · 2008

8 results

[Effects of heptapeptide selank on genetically-based and situation-provoked symptoms of depression in behavior in WAG/Rij and Wistar rats, and in BALB/c mice].

Sarkisova KIu, Kozlovskiĭ II, Kozlovskaia MM

Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova1 Mar 2008

PMID18661785 (opens in a new tab)PepBankPUB-18661785
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In WAG/Rij rats, repeated high-dose selank counteracted the increased immobilization in the forced swimming test.

    In plain wordsIn rats bred for depression-like behavior, repeated high doses of selank reduced the immobility seen in the swim test.

    Peptide
    Selank
    Outcome
    DecreaseImmobilization in forced swimming test
    Study

    ratn: not reported in source

    WAG/Rij rats (genetically-based depression)
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    1000-2000 microg/kgAs given in this study (rat).

    Source sentences

    Summary
    Selank in high doses (1000-2000 microg/kg), after repeated injection counteracted symptoms of depression in behavior of WAG/Rij rats (increased immobilization in the forced swimming test and decreased sucrose intake or preference (anhedonia)).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In WAG/Rij rats, repeated high-dose selank counteracted the decreased sucrose intake or preference.

    In plain wordsIn rats bred for depression-like behavior, repeated high doses of selank reversed the lower sugar-water intake.

    Peptide
    Selank
    Outcome
    IncreaseSucrose intake or preference (anhedonia)
    Study

    ratn: not reported in source

    WAG/Rij rats (genetically-based depression)
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    1000-2000 microg/kgAs given in this study (rat).

    Source sentences

    Summary
    Selank in high doses (1000-2000 microg/kg), after repeated injection counteracted symptoms of depression in behavior of WAG/Rij rats (increased immobilization in the forced swimming test and decreased sucrose intake or preference (anhedonia)).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In BALB/c mice, a single injection of low-dose selank reduced the duration of immobility in the forced swimming test.

    In plain wordsIn mice, one low dose of selank shortened the time spent immobile in the swim test.

    Peptide
    Selank
    Outcome
    DecreaseImmobility duration in forced swimming test after single low dose
    Study

    mousen: not reported in source

    BALB/c mice (situation-provoked depression)
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    100 and 300 microg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Selank in low doses (100 and 300 microg/kg) after single injection reduced the duration of immobility of BALB/c mice in the forced swimming test, but did not exert significant effect after repeated injection or after injection in high doses (600 and 900 microg/kg).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In BALB/c mice, repeated injection of selank had no significant effect on immobility in the forced swimming test.

    In plain wordsIn mice, repeated selank injections did not significantly change time spent immobile in the swim test.

    Peptide
    Selank
    Outcome
    No significant changeImmobility duration in forced swimming test after repeated injection
    Study

    mousen: not reported in source

    BALB/c mice (situation-provoked depression)
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Selank in low doses (100 and 300 microg/kg) after single injection reduced the duration of immobility of BALB/c mice in the forced swimming test, but did not exert significant effect after repeated injection or after injection in high doses (600 and 900 microg/kg).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In BALB/c mice, high-dose selank had no significant effect on immobility in the forced swimming test.

    In plain wordsIn mice, high doses of selank did not significantly change time spent immobile in the swim test.

    Peptide
    Selank
    Outcome
    No significant changeImmobility duration in forced swimming test after high doses
    Study

    mousen: not reported in source

    BALB/c mice (situation-provoked depression)
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    600 and 900 microg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Selank in low doses (100 and 300 microg/kg) after single injection reduced the duration of immobility of BALB/c mice in the forced swimming test, but did not exert significant effect after repeated injection or after injection in high doses (600 and 900 microg/kg).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In WAG/Rij rats, selank did not affect the level of general locomotor activity.

    In plain wordsIn rats bred for depression-like behavior, selank did not change general movement activity.

    Peptide
    Selank
    Outcome
    No significant changeGeneral locomotor activity
    Study

    ratn: not reported in source

    WAG/Rij rats (genetically-based depression)
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Selank did not affect the level of general locomotor activity and anxiety in WAG/Rij rats, and did not exert substantial effect on the behavior of control Wistar rats.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In WAG/Rij rats, selank did not affect the level of anxiety.

    In plain wordsIn rats bred for depression-like behavior, selank did not change anxiety.

    Peptide
    Selank
    Outcome
    No significant changeAnxiety
    Study

    ratn: not reported in source

    WAG/Rij rats (genetically-based depression)
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Selank did not affect the level of general locomotor activity and anxiety in WAG/Rij rats, and did not exert substantial effect on the behavior of control Wistar rats.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In control outbred Wistar rats, selank did not exert a substantial effect on behavior.

    In plain wordsIn normal control rats, selank did not substantially change behavior.

    Peptide
    Selank
    Outcome
    No significant changeBehavior of control Wistar rats
    Study

    ratn: not reported in source

    Outbred Wistar rats (control)
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Selank did not affect the level of general locomotor activity and anxiety in WAG/Rij rats, and did not exert substantial effect on the behavior of control Wistar rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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