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Study · Not a test of the peptide alone · 2008

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The commensal Streptococcus salivarius K12 downregulates the innate immune responses of human epithelial cells and promotes host-microbe homeostasis.

Cosseau C, Devine DA, Dullaghan E, Gardy JL, Chikatamarla A, Gellatly S, Yu LL, Pistolic J, Falsafi R, Tagg J, Hancock RE

Infection and immunity14 Jul 2008Cited by 220 (Europe PMC)

PMID18625732 (opens in a new tab)PMCIDPMC2519405 (opens in a new tab)DOI10.1128/iai.00188-08 (opens in a new tab)PepBankPUB-18625732
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking LL-37.

  1. 01LabNot a test of LL-37 aloneIn vitro (cells)Mechanism

    In human bronchial epithelial cells, Streptococcus salivarius K12 inhibited the IL-8 response to LL‑37.

    In plain wordsIn cells, a harmless mouth bacterium reduced the inflammatory IL-8 response triggered by LL‑37.

    Peptide
    LL-37
    Outcome
    DecreaseIL-8 response to LL-37
    Study

    humann: not reported in source

    human bronchial epithelial cells (16HBE14O-)
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    It inhibited baseline IL-8 secretion and IL-8 responses to LL-37, Pseudomonas aeruginosa, and flagellin in epithelial cells

    In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:58 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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