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Study · Randomized controlled trial · n = 10 · 2008

15 results

Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men.

Clodi M, Vila G, Geyeregger R, Riedl M, Stulnig TM, Struck J, Luger TA, Luger A

American journal of physiology. Endocrinology and metabolism1 Jul 2008Cited by 128 (Europe PMC)

PMID18593851 (opens in a new tab)DOI10.1152/ajpendo.90263.2008 (opens in a new tab)PepBankPUB-18593851
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. 12 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy men with experimental endotoxemia, oxytocin transiently or persistently reduced the endotoxin-induced rise in plasma ACTH.

    In plain wordsIn healthy men given bacterial endotoxin, oxytocin lowered the rise in ACTH compared with endotoxin alone.

    Peptide
    Oxytocin
    Outcome
    DecreaseEndotoxin-induced rise in plasma ACTH
    Study

    n = 10

    Comparator
    LPS alone
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin treatment resulted in a transient or prolonged reduction of endotoxin-induced increases in plasma ACTH, cortisol, procalcitonin, TNF-alpha, IL-1 receptor antagonist, IL-4, IL-6, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, monocyte chemoattractant protein-1…
    1 context sentence
    Summary · context
    Ten healthy men received, in a randomized, placebo-controlled, crossover design, placebo, oxytocin, LPS, and LPS + oxytocin.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy men with experimental endotoxemia, oxytocin transiently or persistently reduced the endotoxin-induced rise in plasma cortisol.

    In plain wordsIn healthy men given bacterial endotoxin, oxytocin lowered the rise in cortisol compared with endotoxin alone.

    Peptide
    Oxytocin
    Outcome
    DecreaseEndotoxin-induced rise in plasma cortisol
    Study

    n = 10

    Comparator
    LPS alone
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin treatment resulted in a transient or prolonged reduction of endotoxin-induced increases in plasma ACTH, cortisol, procalcitonin, TNF-alpha, IL-1 receptor antagonist, IL-4, IL-6, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, monocyte chemoattractant protein-1…
    1 context sentence
    Summary · context
    Ten healthy men received, in a randomized, placebo-controlled, crossover design, placebo, oxytocin, LPS, and LPS + oxytocin.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy men with experimental endotoxemia, oxytocin transiently or persistently reduced the endotoxin-induced rise in plasma procalcitonin.

    In plain wordsIn healthy men given bacterial endotoxin, oxytocin lowered the rise in procalcitonin compared with endotoxin alone.

    Peptide
    Oxytocin
    Outcome
    DecreaseEndotoxin-induced rise in plasma procalcitonin
    Study

    n = 10

    Comparator
    LPS alone
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin treatment resulted in a transient or prolonged reduction of endotoxin-induced increases in plasma ACTH, cortisol, procalcitonin, TNF-alpha, IL-1 receptor antagonist, IL-4, IL-6, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, monocyte chemoattractant protein-1…
    1 context sentence
    Summary · context
    Ten healthy men received, in a randomized, placebo-controlled, crossover design, placebo, oxytocin, LPS, and LPS + oxytocin.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In healthy men with experimental endotoxemia, oxytocin transiently or persistently reduced the endotoxin-induced rise in plasma TNF-alpha.

    In plain wordsIn healthy men given bacterial endotoxin, oxytocin lowered the rise in TNF-alpha compared with endotoxin alone.

    Peptide
    Oxytocin
    Outcome
    DecreaseEndotoxin-induced rise in plasma TNF-alpha
    Study

    n = 10

    Comparator
    LPS alone
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin treatment resulted in a transient or prolonged reduction of endotoxin-induced increases in plasma ACTH, cortisol, procalcitonin, TNF-alpha, IL-1 receptor antagonist, IL-4, IL-6, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, monocyte chemoattractant protein-1…
    1 context sentence
    Summary · context
    Ten healthy men received, in a randomized, placebo-controlled, crossover design, placebo, oxytocin, LPS, and LPS + oxytocin.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In healthy men with experimental endotoxemia, oxytocin transiently or persistently reduced the endotoxin-induced rise in plasma IL-1 receptor antagonist.

    In plain wordsIn healthy men given bacterial endotoxin, oxytocin lowered the rise in IL-1 receptor antagonist compared with endotoxin alone.

    Peptide
    Oxytocin
    Outcome
    DecreaseEndotoxin-induced rise in plasma IL-1 receptor antagonist
    Study

    n = 10

    Comparator
    LPS alone
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin treatment resulted in a transient or prolonged reduction of endotoxin-induced increases in plasma ACTH, cortisol, procalcitonin, TNF-alpha, IL-1 receptor antagonist, IL-4, IL-6, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, monocyte chemoattractant protein-1…
    1 context sentence
    Summary · context
    Ten healthy men received, in a randomized, placebo-controlled, crossover design, placebo, oxytocin, LPS, and LPS + oxytocin.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In healthy men with experimental endotoxemia, oxytocin transiently or persistently reduced the endotoxin-induced rise in plasma IL-4.

    In plain wordsIn healthy men given bacterial endotoxin, oxytocin lowered the rise in IL-4 compared with endotoxin alone.

    Peptide
    Oxytocin
    Outcome
    DecreaseEndotoxin-induced rise in plasma IL-4
    Study

    n = 10

    Comparator
    LPS alone
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin treatment resulted in a transient or prolonged reduction of endotoxin-induced increases in plasma ACTH, cortisol, procalcitonin, TNF-alpha, IL-1 receptor antagonist, IL-4, IL-6, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, monocyte chemoattractant protein-1…
    1 context sentence
    Summary · context
    Ten healthy men received, in a randomized, placebo-controlled, crossover design, placebo, oxytocin, LPS, and LPS + oxytocin.
  7. 07HumanRandomized controlled trialEfficacy outcome

    In healthy men with experimental endotoxemia, oxytocin transiently or persistently reduced the endotoxin-induced rise in plasma IL-6.

    In plain wordsIn healthy men given bacterial endotoxin, oxytocin lowered the rise in IL-6 compared with endotoxin alone.

    Peptide
    Oxytocin
    Outcome
    DecreaseEndotoxin-induced rise in plasma IL-6
    Study

    n = 10

    Comparator
    LPS alone
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin treatment resulted in a transient or prolonged reduction of endotoxin-induced increases in plasma ACTH, cortisol, procalcitonin, TNF-alpha, IL-1 receptor antagonist, IL-4, IL-6, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, monocyte chemoattractant protein-1…
    1 context sentence
    Summary · context
    Ten healthy men received, in a randomized, placebo-controlled, crossover design, placebo, oxytocin, LPS, and LPS + oxytocin.
  8. 08HumanRandomized controlled trialEfficacy outcome

    In healthy men with experimental endotoxemia, oxytocin transiently or persistently reduced the endotoxin-induced rise in plasma macrophage inflammatory protein-1alpha.

    In plain wordsIn healthy men given bacterial endotoxin, oxytocin lowered the rise in macrophage inflammatory protein-1alpha compared with endotoxin alone.

    Peptide
    Oxytocin
    Outcome
    DecreaseEndotoxin-induced rise in plasma macrophage inflammatory protein-1alpha
    Study

    n = 10

    Comparator
    LPS alone
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin treatment resulted in a transient or prolonged reduction of endotoxin-induced increases in plasma ACTH, cortisol, procalcitonin, TNF-alpha, IL-1 receptor antagonist, IL-4, IL-6, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, monocyte chemoattractant protein-1…
    1 context sentence
    Summary · context
    Ten healthy men received, in a randomized, placebo-controlled, crossover design, placebo, oxytocin, LPS, and LPS + oxytocin.
  9. 09HumanRandomized controlled trialEfficacy outcome

    In healthy men with experimental endotoxemia, oxytocin transiently or persistently reduced the endotoxin-induced rise in plasma macrophage inflammatory protein-1beta.

    In plain wordsIn healthy men given bacterial endotoxin, oxytocin lowered the rise in macrophage inflammatory protein-1beta compared with endotoxin alone.

    Peptide
    Oxytocin
    Outcome
    DecreaseEndotoxin-induced rise in plasma macrophage inflammatory protein-1beta
    Study

    n = 10

    Comparator
    LPS alone
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin treatment resulted in a transient or prolonged reduction of endotoxin-induced increases in plasma ACTH, cortisol, procalcitonin, TNF-alpha, IL-1 receptor antagonist, IL-4, IL-6, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, monocyte chemoattractant protein-1…
    1 context sentence
    Summary · context
    Ten healthy men received, in a randomized, placebo-controlled, crossover design, placebo, oxytocin, LPS, and LPS + oxytocin.
  10. 10HumanRandomized controlled trialEfficacy outcome

    In healthy men with experimental endotoxemia, oxytocin transiently or persistently reduced the endotoxin-induced rise in plasma monocyte chemoattractant protein-1 (MCP-1).

    In plain wordsIn healthy men given bacterial endotoxin, oxytocin lowered the rise in MCP-1 compared with endotoxin alone.

    Peptide
    Oxytocin
    Outcome
    DecreaseEndotoxin-induced rise in plasma MCP-1
    Study

    n = 10

    Comparator
    LPS alone
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin treatment resulted in a transient or prolonged reduction of endotoxin-induced increases in plasma ACTH, cortisol, procalcitonin, TNF-alpha, IL-1 receptor antagonist, IL-4, IL-6, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, monocyte chemoattractant protein-1…
    1 context sentence
    Summary · context
    Ten healthy men received, in a randomized, placebo-controlled, crossover design, placebo, oxytocin, LPS, and LPS + oxytocin.
  11. 11HumanRandomized controlled trialEfficacy outcome

    In healthy men with experimental endotoxemia, oxytocin transiently or persistently reduced the endotoxin-induced rise in plasma interferon-inducible protein 10.

    In plain wordsIn healthy men given bacterial endotoxin, oxytocin lowered the rise in interferon-inducible protein 10 compared with endotoxin alone.

    Peptide
    Oxytocin
    Outcome
    DecreaseEndotoxin-induced rise in plasma interferon-inducible protein 10
    Study

    n = 10

    Comparator
    LPS alone
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin treatment resulted in a transient or prolonged reduction of endotoxin-induced increases in plasma ACTH, cortisol, procalcitonin, TNF-alpha, IL-1 receptor antagonist, IL-4, IL-6, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, monocyte chemoattractant protein-1…
    1 context sentence
    Summary · context
    Ten healthy men received, in a randomized, placebo-controlled, crossover design, placebo, oxytocin, LPS, and LPS + oxytocin.
  12. 12HumanRandomized controlled trialEfficacy outcome

    In healthy men with experimental endotoxemia, oxytocin transiently or persistently reduced the endotoxin-induced rise in plasma VEGF.

    In plain wordsIn healthy men given bacterial endotoxin, oxytocin lowered the rise in VEGF compared with endotoxin alone.

    Peptide
    Oxytocin
    Outcome
    DecreaseEndotoxin-induced rise in plasma VEGF
    Study

    n = 10

    Comparator
    LPS alone
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin treatment resulted in a transient or prolonged reduction of endotoxin-induced increases in plasma ACTH, cortisol, procalcitonin, TNF-alpha, IL-1 receptor antagonist, IL-4, IL-6, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, monocyte chemoattractant protein-1…
    1 context sentence
    Summary · context
    Ten healthy men received, in a randomized, placebo-controlled, crossover design, placebo, oxytocin, LPS, and LPS + oxytocin.
  13. 13LabIn vitro (cells)Efficacy outcome

    In human monocytes and peripheral blood mononuclear cells, oxytocin had no impact on LPS-induced TNF-alpha release.

    In plain wordsIn cells from healthy donors, oxytocin did not change how much TNF-alpha endotoxin caused the cells to release.

    Peptide
    Oxytocin
    Outcome
    No significant changeLPS-induced TNF-alpha release in monocytes and PBMC
    Study

    humann: not reported in source

    Monocytes and PBMC from healthy human donors
    Comparator
    LPS alone
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, oxytocin had no impact on LPS effects in releasing TNF-alpha, IL-6, and MCP-1 in monocytes and peripheral blood mononuclear cells from healthy human donors.
  14. 14LabIn vitro (cells)Efficacy outcome

    In human monocytes and peripheral blood mononuclear cells, oxytocin had no impact on LPS-induced IL-6 release.

    In plain wordsIn cells from healthy donors, oxytocin did not change how much IL-6 endotoxin caused the cells to release.

    Peptide
    Oxytocin
    Outcome
    No significant changeLPS-induced IL-6 release in monocytes and PBMC
    Study

    humann: not reported in source

    Monocytes and PBMC from healthy human donors
    Comparator
    LPS alone
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, oxytocin had no impact on LPS effects in releasing TNF-alpha, IL-6, and MCP-1 in monocytes and peripheral blood mononuclear cells from healthy human donors.
  15. 15LabIn vitro (cells)Efficacy outcome

    In human monocytes and peripheral blood mononuclear cells, oxytocin had no impact on LPS-induced MCP-1 release.

    In plain wordsIn cells from healthy donors, oxytocin did not change how much MCP-1 endotoxin caused the cells to release.

    Peptide
    Oxytocin
    Outcome
    No significant changeLPS-induced MCP-1 release in monocytes and PBMC
    Study

    humann: not reported in source

    Monocytes and PBMC from healthy human donors
    Comparator
    LPS alone
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, oxytocin had no impact on LPS effects in releasing TNF-alpha, IL-6, and MCP-1 in monocytes and peripheral blood mononuclear cells from healthy human donors.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

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