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Study · Ex vivo tissue · rabbit · 2008

4 results

Pharmacological profiling of neuropeptides on rabbit vaginal wall and vaginal artery smooth muscle in vitro.

Aughton KL, Hamilton-Smith K, Gupta J, Morton JS, Wayman CP, Jackson VM

British journal of pharmacology30 Jun 2008Cited by 17 (Europe PMC)

PMID18587425 (opens in a new tab)PMCIDPMC2538698 (opens in a new tab)DOI10.1038/bjp.2008.253 (opens in a new tab)PepBankPUB-18587425
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In rabbit vaginal wall strips, bremelanotide at 1 µM did not relax the tissue, unlike alpha-MSH.

    In plain wordsIn lab tests on rabbit tissue, bremelanotide did not relax vaginal wall strips, while alpha-MSH did.

    Peptide
    Bremelanotide (PT-141)
    Outcome
    No significant changeRelaxation of rabbit vaginal wall strips
    Study

    rabbitn: not reported in source

    vaginal wall strips in tissue bath
    Comparator
    Alpha-MSH 1 µM
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    1 µMAs given in this study (rabbit).

    Source sentences

    Summary
    The melanocortin agonist alpha-melanocortin-stimulating hormone (1 microM), but not bremelanotide (1 microM), also relaxed both preparations.
    1 context sentence
    Summary · context
    Tissue bath and wire myography techniques were used to measure isometric tension from strips and arteries, respectively.
  2. 02LabEx vivo tissueActivity measurement

    In rabbit vaginal arteries, bremelanotide at 1 µM did not relax the vessels, unlike alpha-MSH.

    In plain wordsIn lab tests on rabbit tissue, bremelanotide did not relax vaginal arteries, while alpha-MSH did.

    Peptide
    Bremelanotide (PT-141)
    Outcome
    No significant changeRelaxation of rabbit vaginal arteries
    Study

    rabbitn: not reported in source

    vaginal arteries in wire myography
    Comparator
    Alpha-MSH 1 µM
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    1 µMAs given in this study (rabbit).

    Source sentences

    Summary
    The melanocortin agonist alpha-melanocortin-stimulating hormone (1 microM), but not bremelanotide (1 microM), also relaxed both preparations.
    1 context sentence
    Summary · context
    Tissue bath and wire myography techniques were used to measure isometric tension from strips and arteries, respectively.
  3. 03LabEx vivo tissueActivity measurement

    In rabbit vaginal wall strips and vaginal arteries in vitro, oxytocin contracted the vaginal preparations.

    In plain wordsIn lab tests on rabbit vaginal tissue, oxytocin made the tissue contract.

    Peptide
    Oxytocin
    Outcome
    IncreaseContraction of vaginal wall strips and arteries
    Study

    rabbitn: not reported in source

    Vaginal wall strips and vaginal arteries
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin and vasopressin contracted vaginal preparations
    1 context sentence
    Summary · context
    Tissue bath and wire myography techniques were used to measure isometric tension from strips and arteries, respectively.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 04LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In rabbit vaginal preparations in vitro, the V(1A) antagonist SR 49059 antagonized the contraction caused by oxytocin and vasopressin.

    In plain wordsIn lab tests on rabbit vaginal tissue, a vasopressin receptor blocker reduced the contraction caused by oxytocin and vasopressin.

    Peptide
    Oxytocin
    Outcome
    DecreaseAntagonism of oxytocin-induced contraction by V(1A) antagonist SR 49059
    Study

    rabbitn: not reported in source

    Vaginal wall strips and vaginal arteries
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    which could be antagonized by the V(1A) antagonist SR 49059.
    1 context sentence
    Summary · context
    Tissue bath and wire myography techniques were used to measure isometric tension from strips and arteries, respectively.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 38Current

    28 Oct 2026, 02:04 UTC

    The same notice was added 36 times, first on 9 Oct 2026, 18:17 UTC. The status did not change between them.

    Study results updated

  2. Version 2

    9 Oct 2026, 03:04 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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