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Study · In vitro (cells) · 2008

4 results

Insulin-like growth factor binding protein-1 induces decidualization of human endometrial stromal cells via alpha5beta1 integrin.

Matsumoto H, Sakai K, Iwashita M

Molecular human reproduction26 Jun 2008Cited by 38 (Europe PMC)

PMID18583428 (opens in a new tab)DOI10.1093/molehr/gan038 (opens in a new tab)PepBankPUB-18583428
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In cultured human endometrial stromal cells, LR(3)-IGF-I inhibited decidualization induced by MPA and E2.

    In plain wordsIn human uterine cells grown in the lab, LR(3)-IGF-I blocked the change (decidualization) that hormones normally cause.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseDecidualization induced by MPA and E2
    Study

    humann: not reported in source

    cultured human endometrial stromal cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MPA and E(2) induced decidualization of stromal cells, while LR(3)-IGF-I inhibited decidualization by MPA and E(2) as well as PRL and IGFBP-1 secretion into medium.
    1 context sentence
    Summary · context
    Stromal cells were cultured for up to 4 weeks with estradiol (E(2)) and/or medroxy progesterone acetate (MPA) in the presence or the absence of IGFBP-1 and, LR(3)-IGF-I (an IGF-I analogue) that binds to the IGF-I receptor but has reduced affinity for IGFBPs.
  2. 02LabIn vitro (cells)Efficacy outcome

    In cultured human endometrial stromal cells, LR(3)-IGF-I inhibited prolactin secretion into the medium.

    In plain wordsIn human uterine cells grown in the lab, LR(3)-IGF-I reduced prolactin release.

    Peptide
    IGF-1 LR3
    Outcome
    DecreasePRL secretion
    Study

    humann: not reported in source

    cultured human endometrial stromal cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MPA and E(2) induced decidualization of stromal cells, while LR(3)-IGF-I inhibited decidualization by MPA and E(2) as well as PRL and IGFBP-1 secretion into medium.
    1 context sentence
    Summary · context
    Stromal cells were cultured for up to 4 weeks with estradiol (E(2)) and/or medroxy progesterone acetate (MPA) in the presence or the absence of IGFBP-1 and, LR(3)-IGF-I (an IGF-I analogue) that binds to the IGF-I receptor but has reduced affinity for IGFBPs.
  3. 03LabIn vitro (cells)Efficacy outcome

    In cultured human endometrial stromal cells, LR(3)-IGF-I inhibited IGFBP-1 secretion into the medium.

    In plain wordsIn human uterine cells grown in the lab, LR(3)-IGF-I reduced IGFBP-1 release.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseIGFBP-1 secretion
    Study

    humann: not reported in source

    cultured human endometrial stromal cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MPA and E(2) induced decidualization of stromal cells, while LR(3)-IGF-I inhibited decidualization by MPA and E(2) as well as PRL and IGFBP-1 secretion into medium.
    1 context sentence
    Summary · context
    Stromal cells were cultured for up to 4 weeks with estradiol (E(2)) and/or medroxy progesterone acetate (MPA) in the presence or the absence of IGFBP-1 and, LR(3)-IGF-I (an IGF-I analogue) that binds to the IGF-I receptor but has reduced affinity for IGFBPs.
  4. 04LabIn vitro (cells)Efficacy outcome

    In cultured human endometrial stromal cells, LR(3)IGF-1 did not inhibit decidualization induced by IGFBP-1.

    In plain wordsIn human uterine cells grown in the lab, LR(3)IGF-1 did not block decidualization caused by IGFBP-1.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeIGFBP-1-induced decidualization
    Study

    humann: not reported in source

    cultured human endometrial stromal cells
    Comparator
    IGFBP-1 without LR(3)IGF-1
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    IGFBP-1-induced decidualization was not inhibited by the addition of LR(3)IGF-1 but was inhibited by the addition of an RGD peptide, however, the RGD peptide had no effect on decidualization when added alone.
    1 context sentence
    Summary · context
    Stromal cells were cultured for up to 4 weeks with estradiol (E(2)) and/or medroxy progesterone acetate (MPA) in the presence or the absence of IGFBP-1 and, LR(3)-IGF-I (an IGF-I analogue) that binds to the IGF-I receptor but has reduced affinity for IGFBPs.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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