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Study · Not a test of the peptide alone · 2008

2 results

5-HT(2C) receptor activation is a common mechanism on proerectile effects of apomorphine, oxytocin and melanotan-II in rats.

Kimura Y, Naitou Y, Wanibuchi F, Yamaguchi T

European journal of pharmacology24 May 2008Cited by 16 (Europe PMC)

PMID18582863 (opens in a new tab)DOI10.1016/j.ejphar.2008.05.022 (opens in a new tab)PepBankPUB-18582863
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 01AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism

    In rats, the 5-HT(2B)/5-HT(2C) antagonist SB200646 and the 5-HT(2C) antagonist SB242084 significantly inhibited penile erections induced by melanotan II.

    In plain wordsIn rats, two drugs that block serotonin 2C receptors reduced erections caused by melanotan II.

    Peptide
    Melanotan II
    Outcome
    DecreasePenile erections induced by melanotan-II
    Study

    ratn: not reported in source

    Outcome group
    Sexual function · Reproductive and sexual health

    Source sentences

    Summary
    SB200646 at 10 mg/kg and SB242084 at 3 mg/kg, these doses which completely antagonize penile erections induced by 5-HT(2C) receptor agonists, m-chlorophenylpiperazine (mCPP) and (S)-2-(7-ethyl-1H-furo[2,3-g]indazol-1-yl)-1-methylethylamine (YM348), significantly inhibited penile erections elicited b…

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

  2. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In rats, the 5-HT(2B)/5-HT(2C) antagonist SB200646 and the 5-HT(2C) antagonist SB242084 significantly inhibited penile erections induced by oxytocin.

    In plain wordsIn rats, two drugs that block serotonin 2C receptors reduced erections caused by oxytocin.

    Peptide
    Oxytocin
    Outcome
    DecreasePenile erections induced by oxytocin
    Study

    ratn: not reported in source

    Outcome group
    Sexual function · Reproductive and sexual health

    Source sentences

    Summary
    SB200646 at 10 mg/kg and SB242084 at 3 mg/kg, these doses which completely antagonize penile erections induced by 5-HT(2C) receptor agonists, m-chlorophenylpiperazine (mCPP) and (S)-2-(7-ethyl-1H-furo[2,3-g]indazol-1-yl)-1-methylethylamine (YM348), significantly inhibited penile erections elicited b…

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:04 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

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