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Study · Measured the body's own peptide · 2008

4 results

Analysis of neutrophil-derived antimicrobial peptides in gingival crevicular fluid suggests importance of cathelicidin LL-37 in the innate immune response against periodontogenic bacteria.

Puklo M, Guentsch A, Hiemstra PS, Eick S, Potempa J

Oral microbiology and immunology1 Aug 2008Cited by 110 (Europe PMC)

PMID18582333 (opens in a new tab)PMCIDPMC2565510 (opens in a new tab)DOI10.1111/j.1399-302x.2008.00433.x (opens in a new tab)PepBankPUB-18582333
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In gingival crevicular fluid of patients with periodontitis, myeloperoxidase concentration was not correlated with levels of the body's own LL‑37.

    In plain wordsIn gum fluid, the body's own LL‑37 level did not track with myeloperoxidase, a marker of white blood cells.

    Peptide
    LL-37
    Outcome
    No significant changeCorrelation of LL-37 with myeloperoxidase in GCF
    Study

    n = 40

    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    Myeloperoxidase concentration was not correlated with levels of LL-37 and HNP1-3 in samples from patients, compared to controls.
    1 context sentence
    Summary · context
    GCF was collected from 14 patients with aggressive periodontitis, 17 patients with chronic periodontitis, and nine healthy subjects.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    Patients with chronic periodontitis had significantly elevated amounts of mature LL‑37 in gingival crevicular fluid.

    In plain wordsPeople with chronic gum disease had more of the body's own mature LL‑37 in gum fluid.

    Peptide
    LL-37
    Outcome
    IncreaseMature LL-37 in GCF in chronic periodontitis
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    Those with chronic disease had significantly elevated amounts of mature LL-37.
    1 context sentence
    Summary · context
    GCF was collected from 14 patients with aggressive periodontitis, 17 patients with chronic periodontitis, and nine healthy subjects.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In chronic periodontitis, the increased concentration of the body's own LL‑37 in gingival crevicular fluid correlated with the load of P. gingivalis, T. forsythia and T. denticola.

    In plain wordsIn chronic gum disease, more of the body's own LL‑37 in gum fluid was linked to more of three gum bacteria.

    Peptide
    LL-37
    Outcome
    IncreaseCorrelation of GCF LL-37 with periodontopathogen load in chronic periodontitis
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    The increased concentration of both peptides in chronic periodontitis correlated with the load of Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola.
    2 context sentences
    Summary · context
    Those with chronic disease had significantly elevated amounts of mature LL-37.
    Summary · context
    GCF was collected from 14 patients with aggressive periodontitis, 17 patients with chronic periodontitis, and nine healthy subjects.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    An 11-kDa cathelicidin-derived fragment of hCAP18/LL‑37 was present in gingival crevicular fluid from pockets infected with P. gingivalis, T. forsythia and T. denticola.

    In plain wordsGum fluid from pockets with three gum bacteria held a small fragment of the body's own hCAP18/LL‑37.

    Peptide
    LL-37
    Outcome
    Not applicable11-kDa cathelicidin-derived fragment in infected pockets
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    The bacterial proteases of P. gingivalis, T. forsythia, and T. denticola might degrade hCAP18/LL-37, because the 11-kDa cathelicidin-derived fragment was present in GCF collected from pockets infected with these bacteria.
    1 context sentence
    Summary · context
    GCF was collected from 14 patients with aggressive periodontitis, 17 patients with chronic periodontitis, and nine healthy subjects.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:58 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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