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Study · Animal study (in vivo) · mouse · 2008

3 results

Enhancement of maternal lactation performance during prolonged lactation in the mouse by mouse GH and long-R3-IGF-I is linked to changes in mammary signaling and gene expression.

Hadsell DL, Parlow AF, Torres D, George J, Olea W

The Journal of endocrinology1 Jul 2008Cited by 15 (Europe PMC)

PMID18577570 (opens in a new tab)DOI10.1677/joe-07-0556 (opens in a new tab)PepBankPUB-18577570
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In lactating mouse dams, subcutaneous long-R3-IGF-I increased mammary phospho-Akt.

    In plain wordsIn lactating mice, long-R3-IGF-I increased a mammary signaling marker, phospho-Akt.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseMammary phospho-Akt
    Study

    mousen: not reported in source

    lactating mouse dams
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    LR3 increased (P<0.05) mammary phospho-Akt and suppressors of cytokines signaling 3 (SOCS3) gene expression, and had a modest ability to increase (P<0.05) lactation capacity.
    1 context sentence
    Summary · context
    In the present study, murine GH and PRL, and a human IGF-I analog, long-R3-IGF-I (LR3), were administered as s.c. injections to compare their ability to enhance milk production, and alter mammary gland signaling and gene expression.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In lactating mouse dams, subcutaneous long-R3-IGF-I increased mammary SOCS3 gene expression.

    In plain wordsIn lactating mice, long-R3-IGF-I increased mammary SOCS3 gene expression.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseMammary SOCS3 gene expression
    Study

    mousen: not reported in source

    lactating mouse dams
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    LR3 increased (P<0.05) mammary phospho-Akt and suppressors of cytokines signaling 3 (SOCS3) gene expression, and had a modest ability to increase (P<0.05) lactation capacity.
    1 context sentence
    Summary · context
    In the present study, murine GH and PRL, and a human IGF-I analog, long-R3-IGF-I (LR3), were administered as s.c. injections to compare their ability to enhance milk production, and alter mammary gland signaling and gene expression.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In lactating mouse dams, subcutaneous long-R3-IGF-I had a modest ability to increase lactation capacity.

    In plain wordsIn lactating mice, long-R3-IGF-I modestly increased milk production, measured as litter gain.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseLactation capacity (litter gain)
    Study

    mousen: not reported in source

    lactating mouse dams
    Outcome group
    Lactation and milk synthesis · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    LR3 increased (P<0.05) mammary phospho-Akt and suppressors of cytokines signaling 3 (SOCS3) gene expression, and had a modest ability to increase (P<0.05) lactation capacity.
    2 context sentences
    Summary · context
    Lactation capacity, as measured by litter gain, was increased (P<0.05) by GH, but not by PRL.
    Summary · context
    In the present study, murine GH and PRL, and a human IGF-I analog, long-R3-IGF-I (LR3), were administered as s.c. injections to compare their ability to enhance milk production, and alter mammary gland signaling and gene expression.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 4Current

    21 Oct 2026, 13:52 UTC

    The same notice was added 2 times, first on 21 Oct 2026, 12:50 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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