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Study · Measured the body's own peptide · 2008

5 results

Ethnicity is associated with alterations in oxytocin relationships to pain sensitivity in women.

Grewen KM, Light KC, Mechlin B, Girdler SS

Ethnicity & health1 Jun 2008Cited by 51 (Europe PMC)

PMID18568974 (opens in a new tab)PMCIDPMC4624387 (opens in a new tab)DOI10.1080/13557850701837310 (opens in a new tab)PepBankPUB-18568974
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In pre-menopausal women, plasma oxytocin was lower in African American women than in non-Hispanic White women.

    In plain wordsIn women, the body's own oxytocin level was lower in African American women than in White women.

    Peptide
    Oxytocin
    Outcome
    DecreasePlasma oxytocin in African American versus non-Hispanic White women
    Study

    n = 48

    Comparator
    Non-Hispanic White women
    Outcome group
    Pain · Nervous system and cognition

    Measurements

    Plasma OT
    3.9 pg/mL
    African American women
    Plasma OT
    7.05 pg/mL
    non-Hispanic White women

    Source sentences

    Summary
    African American women demonstrated significantly lower pain tolerance across tasks compared with Whites (F(1,46)=6.31, p=0.0156) and also exhibited lower plasma OT levels (AA: 3.90, W: 7.05 pg/mL; p=0.0014).
    1 context sentence
    Summary · context
    OT concentration and sensitivity to ischemic, cold pressor, and thermal pain tasks were assessed in African American (n=25) and non-Hispanic White (n=23) pre-menopausal women.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In pre-menopausal women, higher plasma oxytocin was correlated with greater tolerance of ischemic pain.

    In plain wordsIn women, higher natural oxytocin levels were linked to greater tolerance of ischemic pain.

    Peptide
    Oxytocin
    Outcome
    IncreaseAssociation of plasma oxytocin with ischemic pain tolerance
    Study

    n = 48

    Outcome group
    Pain · Nervous system and cognition

    Measurements

    r
    0.36
    ischemic pain tolerance

    Source sentences

    Summary
    Greater OT levels were correlated with greater tolerance to ischemic pain (r=0.36, p=0.013)
    1 context sentence
    Summary · context
    OT concentration and sensitivity to ischemic, cold pressor, and thermal pain tasks were assessed in African American (n=25) and non-Hispanic White (n=23) pre-menopausal women.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In pre-menopausal women, plasma oxytocin accounted for only a marginally significant portion of the ethnic difference in ischemic pain tolerance.

    In plain wordsIn women, natural oxytocin levels explained only a small, borderline part of the ethnic difference in tolerance of ischemic pain.

    Peptide
    Oxytocin
    Outcome
    No significant changeShare of ethnic difference in ischemic pain tolerance accounted for by oxytocin
    Study

    n = 48

    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    and accounted for a marginally significant portion of the ethnic difference in ischemic pain tolerance (B=+0.29, p=0.06).
    1 context sentence
    Summary · context
    OT concentration and sensitivity to ischemic, cold pressor, and thermal pain tasks were assessed in African American (n=25) and non-Hispanic White (n=23) pre-menopausal women.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In pre-menopausal women, higher plasma oxytocin was correlated with greater tolerance of cold pressor pain.

    In plain wordsIn women, higher natural oxytocin levels were linked to greater tolerance of cold pressor pain.

    Peptide
    Oxytocin
    Outcome
    IncreaseAssociation of plasma oxytocin with cold pressor pain tolerance
    Study

    n = 48

    Outcome group
    Pain · Nervous system and cognition

    Measurements

    r
    0.31
    cold pressor pain tolerance

    Source sentences

    Summary
    Greater OT was also correlated with greater tolerance of cold pressor pain (r=0.31, p=0.03)
    1 context sentence
    Summary · context
    OT concentration and sensitivity to ischemic, cold pressor, and thermal pain tasks were assessed in African American (n=25) and non-Hispanic White (n=23) pre-menopausal women.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelObservational studyOther

    In pre-menopausal women, the association between plasma oxytocin and cold pressor pain tolerance was no longer seen after the variance due to ethnicity was accounted for.

    In plain wordsIn women, the link between natural oxytocin levels and cold pressor pain tolerance disappeared once ethnicity was taken into account.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin and cold pressor pain tolerance after accounting for ethnicity
    Study

    n = 48

    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    however, this association was no longer seen after the variance due to ethnicity was accounted for.
    1 context sentence
    Summary · context
    OT concentration and sensitivity to ischemic, cold pressor, and thermal pain tasks were assessed in African American (n=25) and non-Hispanic White (n=23) pre-menopausal women.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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