Oxytocin-induced contractions within rat and rabbit ejaculatory tissues are mediated by vasopressin V1A receptors and not oxytocin receptors.

Gupta J, Russell R, Wayman C, Hurley D, Jackson V

British journal of pharmacology16 Jun 2008Cited by 54 (Europe PMC)

PMID18552879PMCIDPMC2527840DOI10.1038/bjp.2008.226PepBankPUB-18552879

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueActivity measurement
In isolated rat and rabbit testes, vas deferens, epididymis, seminal vesicles and prostate, oxytocin did not elicit a tonic contractile response.
In plain wordsIn lab tests on rat and rabbit tissues, oxytocin did not make testes, vas deferens, epididymis, seminal vesicles or prostate contract.
Peptide
Oxytocin
Outcome
No significant changeTonic contraction in testes, vas deferens, epididymis, seminal vesicles and prostate
Study
rat and rabbitn: not reported in source
Isolated tissue bath
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Oxytocin and AVP failed to elicit a tonic contractile response in rat and rabbit testes, vas deferens, epididymis, seminal vesicles and prostate.
1 context sentence(design, population, supporting numbers)
Summary · context
Standard tissue bath techniques were used to measure isometric tension from tissues involved in ejaculation and erection.
Report a problemFND-1855287901
02LabEx vivo tissueActivity measurement
In isolated rat and rabbit erectile and ejaculatory tissues, oxytocin elicited large concentration-dependent tonic contractions.
In plain wordsIn lab tests on rat and rabbit tissues, oxytocin made erectile and ejaculatory tissues contract strongly, more at higher concentrations.
Peptide
Oxytocin
Outcome
IncreaseTonic contraction of erectile and ejaculatory tissues
Study
rat and rabbitn: not reported in source
Isolated tissue bath
Outcome group
Sexual function · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
In contrast, oxytocin and AVP elicited large tonic contractions in erectile (corpus spongiosum and corpus cavernosum) and ejaculatory (prostatic urethra, bladder neck and ejaculatory duct) tissues in a concentration-dependent manner.
1 context sentence(design, population, supporting numbers)
Summary · context
Standard tissue bath techniques were used to measure isometric tension from tissues involved in ejaculation and erection.
Report a problemFND-1855287902
03LabEx vivo tissueMechanism
In isolated rat and rabbit tissues, oxytocin-induced contractions were only weakly antagonized by the selective oxytocin antagonist L-368899.
In plain wordsIn lab tests on rat and rabbit tissues, a blocker of the oxytocin receptor only weakly reduced oxytocin-induced contractions.
Peptide
Oxytocin
Outcome
Not applicableAntagonism of oxytocin contractions by oxytocin antagonist L-368899
Study
rat and rabbitn: not reported in source
Isolated tissue bath
Comparator
L-368899
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
Oxytocin and AVP-induced contractions were weakly antagonized by the selective oxytocin antagonist, L-368899 but potently antagonized by the V1A antagonist, SR49059.
1 context sentence(design, population, supporting numbers)
Summary · context
Standard tissue bath techniques were used to measure isometric tension from tissues involved in ejaculation and erection.
Report a problemFND-1855287903
04LabEx vivo tissueMechanism
In isolated rat and rabbit tissues, oxytocin-induced contractions were potently antagonized by the V1A antagonist SR49059.
In plain wordsIn lab tests on rat and rabbit tissues, a blocker of the vasopressin V1A receptor strongly reduced oxytocin-induced contractions.
Peptide
Oxytocin
Outcome
Not applicableAntagonism of oxytocin contractions by V1A antagonist SR49059
Study
rat and rabbitn: not reported in source
Isolated tissue bath
Comparator
SR49059
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
Oxytocin and AVP-induced contractions were weakly antagonized by the selective oxytocin antagonist, L-368899 but potently antagonized by the V1A antagonist, SR49059.
1 context sentence(design, population, supporting numbers)
Summary · context
Standard tissue bath techniques were used to measure isometric tension from tissues involved in ejaculation and erection.
Report a problemFND-1855287904

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 01:30 UTC
Study results updated
Version 1
9 Oct 2026, 02:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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