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Study · In vitro (cells) · 2008

10 results

[Biological activity of regulatory peptides in model experiments in vitro].

Kozina LS, Arutiunian AV, Stvolinskiĭ SL, Khavinson VKh

Advances in gerontology = Uspekhi gerontologii1 Jan 2008Cited by 2 (Europe PMC)

PMID18546826 (opens in a new tab)PepBankPUB-18546826
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In neuronal cells in vitro, epitalon was the exception among four short peptides and did not decrease the percent of dead cells.

    In plain wordsIn nerve cells in the lab, epitalon did not lower cell death, unlike the other three short peptides.

    Peptide
    Epitalon
    Outcome
    No significant changePercent of dead cells in neuronal population
    Study

    n: not reported in source

    In vitro model experiments
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    decrease (all excepting epitalon) percent of dead cells in neuronal population.
    1 context sentence
    Summary · context
    Biological effects of short regulatory peptides, pinealon, vesugen, vilon and epitalon were studied in model experiments in vitro.

Studies that did not test the peptide alone9

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 02LabNot a test of Epitalon aloneIn vitro (cells)Activity measurement

    In red blood cells in vitro, the short peptides including epitalon increased the stability of cell membranes toward osmotic hemolysis.

    In plain wordsIn lab tests, epitalon and three other short peptides made red blood cell membranes more resistant to bursting.

    Peptide
    Epitalon
    Outcome
    IncreaseRed blood cell membrane stability toward osmotic hemolysis
    Study

    n: not reported in source

    In vitro model experiments
    Outcome group
    Receptor activity and mechanism · Whole body

    Source sentences

    Summary
    The short peptides increase stability of red blood cell membranes toward osmotic hemolysis.
    1 context sentence
    Summary · context
    Biological effects of short regulatory peptides, pinealon, vesugen, vilon and epitalon were studied in model experiments in vitro.

    In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.

  2. 03LabNot a test of Epitalon aloneIn vitro (cells)Activity measurement

    In neuronal cells in vitro, the short peptides including epitalon elevated the stationary level of intracellular reactive oxygen species.

    In plain wordsIn nerve cells in the lab, epitalon and three other short peptides raised the level of reactive oxygen species in cells.

    Peptide
    Epitalon
    Outcome
    IncreaseStationary level of intracellular reactive oxygen species
    Study

    n: not reported in source

    In vitro model experiments
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    They also elevate the stationary level of intracellular reactive oxygen species
    1 context sentence
    Summary · context
    Biological effects of short regulatory peptides, pinealon, vesugen, vilon and epitalon were studied in model experiments in vitro.

    In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.

  3. 04LabNot a test of Pinealon aloneIn vitro (cells)Activity measurement

    In vitro, the short-peptide group including pinealon increased red blood cell membrane stability toward osmotic hemolysis.

    In plain wordsIn cells, the short-peptide group including pinealon increased red blood cell membrane resistance to osmotic rupture.

    Peptide
    Pinealon
    Outcome
    IncreaseMembrane stability toward osmotic hemolysis
    Study

    n: not reported in source

    Red blood cells
    Outcome group
    Receptor activity and mechanism · Whole body

    Source sentences

    Summary
    The short peptides increase stability of red blood cell membranes toward osmotic hemolysis.
    1 context sentence
    Summary · context
    Biological effects of short regulatory peptides, pinealon, vesugen, vilon and epitalon were studied in model experiments in vitro.

    In this study, Pinealon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Pinealon.

  4. 05LabNot a test of Pinealon aloneIn vitro (cells)Activity measurement

    In vitro, the short-peptide group including pinealon increased the stationary level of intracellular reactive oxygen species.

    In plain wordsIn cells, the short-peptide group including pinealon increased steady intracellular reactive oxygen species levels.

    Peptide
    Pinealon
    Outcome
    IncreaseStationary intracellular reactive oxygen species level
    Study

    n: not reported in source

    Neuronal population
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    They also elevate the stationary level of intracellular reactive oxygen species and at the same time decrease (all excepting epitalon) percent of dead cells in neuronal population.
    1 context sentence
    Summary · context
    Biological effects of short regulatory peptides, pinealon, vesugen, vilon and epitalon were studied in model experiments in vitro.

    In this study, Pinealon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Pinealon.

  5. 06LabNot a test of Pinealon aloneIn vitro (cells)Activity measurement

    In vitro, the short-peptide group excluding epitalon, but including pinealon, decreased the percentage of dead neuronal cells.

    In plain wordsIn cells, the short-peptide group including pinealon and excluding epitalon reduced the percentage of dead nerve cells.

    Peptide
    Pinealon
    Outcome
    DecreaseDead neuronal cell percentage
    Study

    n: not reported in source

    Neuronal population
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    They also elevate the stationary level of intracellular reactive oxygen species and at the same time decrease (all excepting epitalon) percent of dead cells in neuronal population.
    1 context sentence
    Summary · context
    Biological effects of short regulatory peptides, pinealon, vesugen, vilon and epitalon were studied in model experiments in vitro.

    In this study, Pinealon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Pinealon.

  6. 07LabNot a test of Epitalon aloneIn vitro (cell-free)Activity measurement

    In lab tests, the short peptides pinealon, vesugen, vilon and epitalon showed no direct antioxidant activity.

    In plain wordsIn lab tests, epitalon and three other short peptides did not show direct antioxidant activity.

    Peptide
    Epitalon
    Outcome
    No significant changeDirect antioxidant activity
    Study

    n: not reported in source

    In vitro model experiments
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    These peptides were found not to demonstrate direct antioxidant activity
    1 context sentence
    Summary · context
    Biological effects of short regulatory peptides, pinealon, vesugen, vilon and epitalon were studied in model experiments in vitro.

    In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.

  7. 08LabNot a test of Epitalon aloneIn vitro (cell-free)Activity measurement

    In lab tests, the short peptides including epitalon restricted lipid peroxidation of human lipoproteins by modifying their structure.

    In plain wordsIn lab tests, epitalon and three other short peptides limited fat oxidation in human lipoproteins.

    Peptide
    Epitalon
    Outcome
    DecreaseLipid peroxidation of human lipoproteins
    Study

    humann: not reported in source

    Human lipoproteins
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    be able to restrict lipid peroxidation of human lipoproteins by modification of their structure.
    1 context sentence
    Summary · context
    Biological effects of short regulatory peptides, pinealon, vesugen, vilon and epitalon were studied in model experiments in vitro.

    In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.

  8. 09LabNot a test of Pinealon aloneIn vitro (cell-free)Activity measurement

    In vitro, the short-peptide group including pinealon showed no direct antioxidant activity.

    In plain wordsIn lab tests, the short-peptide group including pinealon showed no direct antioxidant activity.

    Peptide
    Pinealon
    Outcome
    No significant changeDirect antioxidant activity
    Study

    n: not reported in source

    In vitro model experiments
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    These peptides were found not to demonstrate direct antioxidant activity but be able to restrict lipid peroxidation of human lipoproteins by modification of their structure.
    1 context sentence
    Summary · context
    Biological effects of short regulatory peptides, pinealon, vesugen, vilon and epitalon were studied in model experiments in vitro.

    In this study, Pinealon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Pinealon.

  9. 10LabNot a test of Pinealon aloneIn vitro (cell-free)Activity measurement

    In vitro, the short-peptide group including pinealon restricted lipid peroxidation of human lipoproteins through structural modification.

    In plain wordsIn lab tests, the short-peptide group including pinealon reduced lipid peroxidation in human lipoproteins through structural changes.

    Peptide
    Pinealon
    Outcome
    DecreaseLipoprotein lipid peroxidation
    Study

    humann: not reported in source

    Human lipoproteins
    Outcome group
    Lipids · Cardiovascular

    Source sentences

    Summary
    These peptides were found not to demonstrate direct antioxidant activity but be able to restrict lipid peroxidation of human lipoproteins by modification of their structure.
    1 context sentence
    Summary · context
    Biological effects of short regulatory peptides, pinealon, vesugen, vilon and epitalon were studied in model experiments in vitro.

    In this study, Pinealon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Pinealon.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 8 to 15Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 8 times, first on 21 Oct 2026, 17:05 UTC. The status did not change between them.

    Study results updated

  2. Version 7

    21 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  3. Versions 4 to 6

    21 Oct 2026, 15:58 UTC

    The same notice was added 3 times, first on 14 Oct 2026, 05:02 UTC. The status did not change between them.

    Study results updated

  4. Version 3

    14 Oct 2026, 01:46 UTC

    Study data updated · source update from Europe PMC

  5. Version 2

    12 Oct 2026, 17:28 UTC

    Study results updated

  6. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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