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Study · Animal study (in vivo) · 2008

6 results

[Investigation of antihypoxic properties of short peptides].

Kozina LS

Advances in gerontology = Uspekhi gerontologii1 Jan 2008

PMID18546825 (opens in a new tab)PepBankPUB-18546825
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In hypobaric hypoxia experiments, pinealon had the most pronounced antihypoxic effect among the tested peptides.

    In plain wordsIn animal experiments with hypobaric hypoxia, pinealon had a stronger antihypoxic effect than the other tested peptides.

    Peptide
    Pinealon
    Outcome
    IncreaseComparative antihypoxic effect
    Study

    n: not reported in source

    Hypobaric hypoxia
    Comparator
    Vilon, epitalon and vesugen
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pinealon (Glu-Asp-Arg) has the most pronounced effect among them.
    1 context sentence
    Summary · context
    The data presented suggest that short regulatory peptides (vilon, epitalon, vesugen and pinealon) have manifested the antihypoxic properties in the model of hypobaric hypoxia.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In prenatal hypoxia experiments, pinealon increased neuronal resistance to hypoxic stress.

    In plain wordsIn animal experiments with prenatal hypoxia, pinealon increased nerve cell resistance to hypoxic stress.

    Peptide
    Pinealon
    Outcome
    IncreaseNeuronal resistance to hypoxic stress
    Study

    n: not reported in source

    Prenatal hypoxia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The capability of pinealon to increase the neuronal resistance to hypoxic stress in experiments with prenatal hypoxia has a complex nature.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In prenatal hypoxia experiments, pinealon's neuronal protection involved stimulation of the internal antioxidative enzyme system.

    In plain wordsIn animal experiments with prenatal hypoxia, pinealon's nerve cell protection involved stimulation of internal antioxidant enzymes.

    Peptide
    Pinealon
    Outcome
    IncreaseInternal antioxidative enzyme system
    Study

    n: not reported in source

    Prenatal hypoxia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It is based not so much on the inhibition of ROS increase in cells in response to stress as on stimulation of internal antioxidative enzyme system and possibly limiting the excitotoxic effect of N-methyl-D-aspartate.
    1 context sentence
    Summary · context
    The capability of pinealon to increase the neuronal resistance to hypoxic stress in experiments with prenatal hypoxia has a complex nature.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In prenatal hypoxia experiments, pinealon's neuronal protection possibly involved limiting the excitotoxic effect of N-methyl-D-aspartate.

    In plain wordsIn animal experiments with prenatal hypoxia, pinealon possibly limited nerve cell toxicity from N-methyl-D-aspartate.

    Peptide
    Pinealon
    Outcome
    DecreaseN-methyl-D-aspartate excitotoxicity
    Study

    n: not reported in source

    Prenatal hypoxia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It is based not so much on the inhibition of ROS increase in cells in response to stress as on stimulation of internal antioxidative enzyme system and possibly limiting the excitotoxic effect of N-methyl-D-aspartate.
    1 context sentence
    Summary · context
    The capability of pinealon to increase the neuronal resistance to hypoxic stress in experiments with prenatal hypoxia has a complex nature.

Studies that did not test the peptide alone2

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 05AnimalNot a test of Epitalon aloneAnimal study (in vivo)Efficacy outcome

    In a model of hypobaric hypoxia, the short regulatory peptides vilon, epitalon, vesugen and pinealon showed antihypoxic properties.

    In plain wordsIn an animal model of low oxygen, epitalon and three other short peptides showed protective effects against oxygen shortage.

    Peptide
    Epitalon
    Outcome
    Not applicableAntihypoxic properties in hypobaric hypoxia
    Study

    n: not reported in source

    Hypobaric hypoxia
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    The data presented suggest that short regulatory peptides (vilon, epitalon, vesugen and pinealon) have manifested the antihypoxic properties in the model of hypobaric hypoxia.

    In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.

  2. 06AnimalNot a test of Pinealon aloneAnimal study (in vivo)Efficacy outcome

    In hypobaric hypoxia experiments, the short-peptide group including pinealon showed antihypoxic properties.

    In plain wordsIn animal experiments with hypobaric hypoxia, the short-peptide group including pinealon showed antihypoxic properties.

    Peptide
    Pinealon
    Outcome
    Not applicableAntihypoxic activity
    Study

    n: not reported in source

    Hypobaric hypoxia
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    The data presented suggest that short regulatory peptides (vilon, epitalon, vesugen and pinealon) have manifested the antihypoxic properties in the model of hypobaric hypoxia.

    In this study, Pinealon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Pinealon.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 8 to 15Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 8 times, first on 21 Oct 2026, 17:05 UTC. The status did not change between them.

    Study results updated

  2. Version 7

    21 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  3. Versions 4 to 6

    21 Oct 2026, 15:58 UTC

    The same notice was added 3 times, first on 14 Oct 2026, 05:02 UTC. The status did not change between them.

    Study results updated

  4. Version 3

    14 Oct 2026, 01:46 UTC

    Study data updated · source update from Europe PMC

  5. Version 2

    12 Oct 2026, 17:28 UTC

    Study results updated

  6. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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