Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice.

Sugiyama T, Saxon LK, Zaman G, Moustafa A, Sunters A, Price JS, Lanyon LE

Bone1 May 2008Cited by 144 (Europe PMC)

PMID18539556DOI10.1016/j.bone.2008.04.012PepBankPUB-18539556

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In mice, intermittent PTH modified bone structure in a dose- and time-dependent manner, especially in proximal tibial trabecular bone.
In plain wordsIn mice, PTH changed bone structure according to dose and treatment time, especially near the upper tibia.
Peptide
Teriparatide (PTH 1-34)
Outcome
MixedBone structure
Study
mousen: not reported in source
Female C57BL/6 mice with mechanical bone loading
Outcome group
Bone and joint · Musculoskeletal
Studied dose
20, 40 or 80 microg/kg/day · injectionAs given in this study (mouse).
Source sentences
Summary
Treatment with iPTH (1-34) modified bone structure in a dose- and time-dependent manner, which was particularly evident in the trabecular region of the proximal tibia.
2 context sentences(design, population, supporting numbers)
Summary · context
The separate and combined effects of intermittent parathyroid hormone (iPTH) (1-34) and mechanical loading were assessed at trabecular and cortical sites of mouse long bones.
Summary · context
Female C57BL/6 mice from 13 to 19 weeks of age were given daily injections of vehicle or PTH (1-34) at low (20 microg/kg/day), medium (40 microg/kg/day) or high (80 microg/kg/day) dose.
Report a problemFND-1853955601
02AnimalAnimal study (in vivo)Efficacy outcome
In mice, PTH alone did not induce woven bone formation.
In plain wordsIn mice, PTH alone did not induce woven bone formation.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeWoven bone formation with PTH alone
Study
mousen: not reported in source
Female C57BL/6 mice with mechanical bone loading
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
No woven bone was induced by iPTH (1-34) or either level of loading alone,
2 context sentences(design, population, supporting numbers)
Summary · context
The separate and combined effects of intermittent parathyroid hormone (iPTH) (1-34) and mechanical loading were assessed at trabecular and cortical sites of mouse long bones.
Summary · context
Female C57BL/6 mice from 13 to 19 weeks of age were given daily injections of vehicle or PTH (1-34) at low (20 microg/kg/day), medium (40 microg/kg/day) or high (80 microg/kg/day) dose.
Report a problemFND-1853955609

Studies that did not test the peptide alone8

In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Teriparatide (PTH 1-34).

03AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In mice receiving low-dose PTH, sufficient mechanical loading produced trabecular osteogenesis in the tibia.
In plain wordsIn mice receiving low-dose PTH, sufficient mechanical loading stimulated tibial trabecular bone formation.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseLoaded tibial trabecular osteogenesis
Study
mousen: not reported in source
Female C57BL/6 mice with mechanical bone loading
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
In the tibia, loading at a level sufficient by itself to stimulate osteogenesis produced an osteogenic response in the low-dose iPTH (1-34)-treated trabecular bone and in the proximal and middle cortical bone treated with all doses of iPTH (1-34).
2 context sentences(design, population, supporting numbers)
Summary · context
The separate and combined effects of intermittent parathyroid hormone (iPTH) (1-34) and mechanical loading were assessed at trabecular and cortical sites of mouse long bones.
Summary · context
Female C57BL/6 mice from 13 to 19 weeks of age were given daily injections of vehicle or PTH (1-34) at low (20 microg/kg/day), medium (40 microg/kg/day) or high (80 microg/kg/day) dose.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1853955602
04AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In mice receiving PTH at all tested doses, sufficient loading produced osteogenesis in proximal and middle tibial cortical bone.
In plain wordsIn mice receiving PTH, sufficient loading stimulated bone formation in upper and middle tibial cortex.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseLoaded tibial cortical osteogenesis
Study
mousen: not reported in source
Female C57BL/6 mice with mechanical bone loading
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
In the tibia, loading at a level sufficient by itself to stimulate osteogenesis produced an osteogenic response in the low-dose iPTH (1-34)-treated trabecular bone and in the proximal and middle cortical bone treated with all doses of iPTH (1-34).
2 context sentences(design, population, supporting numbers)
Summary · context
The separate and combined effects of intermittent parathyroid hormone (iPTH) (1-34) and mechanical loading were assessed at trabecular and cortical sites of mouse long bones.
Summary · context
Female C57BL/6 mice from 13 to 19 weeks of age were given daily injections of vehicle or PTH (1-34) at low (20 microg/kg/day), medium (40 microg/kg/day) or high (80 microg/kg/day) dose.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1853955603
05AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In mice, otherwise insufficient loading became osteogenic in the distal ulna when combined with high-dose PTH.
In plain wordsIn mice, loading combined with high-dose PTH stimulated distal ulnar bone formation when loading alone did not.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseDistal ulnar osteogenesis
Study
mousen: not reported in source
Female C57BL/6 mice with mechanical bone loading
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
In the ulna, loading at a level that did not by itself stimulate osteogenesis was osteogenic at the distal site when combined with high-dose iPTH (1-34).
2 context sentences(design, population, supporting numbers)
Summary · context
The separate and combined effects of intermittent parathyroid hormone (iPTH) (1-34) and mechanical loading were assessed at trabecular and cortical sites of mouse long bones.
Summary · context
Female C57BL/6 mice from 13 to 19 weeks of age were given daily injections of vehicle or PTH (1-34) at low (20 microg/kg/day), medium (40 microg/kg/day) or high (80 microg/kg/day) dose.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1853955604
06AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In mice, high-dose PTH and loading showed synergistic effects on proximal tibial cortical bone volume.
In plain wordsIn mice, high-dose PTH and loading acted synergistically to increase upper tibial cortical bone volume.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseProximal tibial cortical bone volume
Study
mousen: not reported in source
Female C57BL/6 mice with mechanical bone loading
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
At both levels of loading, there were synergistic effects in cortical bone volume of the proximal tibia and distal ulna between loading and high-dose iPTH (1-34).
2 context sentences(design, population, supporting numbers)
Summary · context
The separate and combined effects of intermittent parathyroid hormone (iPTH) (1-34) and mechanical loading were assessed at trabecular and cortical sites of mouse long bones.
Summary · context
Female C57BL/6 mice from 13 to 19 weeks of age were given daily injections of vehicle or PTH (1-34) at low (20 microg/kg/day), medium (40 microg/kg/day) or high (80 microg/kg/day) dose.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1853955605
07AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In mice, high-dose PTH and loading showed synergistic effects on distal ulnar cortical bone volume.
In plain wordsIn mice, high-dose PTH and loading acted synergistically to increase distal ulnar cortical bone volume.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseDistal ulnar cortical bone volume
Study
mousen: not reported in source
Female C57BL/6 mice with mechanical bone loading
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
At both levels of loading, there were synergistic effects in cortical bone volume of the proximal tibia and distal ulna between loading and high-dose iPTH (1-34).
2 context sentences(design, population, supporting numbers)
Summary · context
The separate and combined effects of intermittent parathyroid hormone (iPTH) (1-34) and mechanical loading were assessed at trabecular and cortical sites of mouse long bones.
Summary · context
Female C57BL/6 mice from 13 to 19 weeks of age were given daily injections of vehicle or PTH (1-34) at low (20 microg/kg/day), medium (40 microg/kg/day) or high (80 microg/kg/day) dose.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1853955606
08AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In mice, synergistic effects of PTH and loading reflected increased endosteal bone formation.
In plain wordsIn mice, PTH with loading increased bone formation on inner bone surfaces.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseEndosteal bone formation
Study
mousen: not reported in source
Female C57BL/6 mice with mechanical bone loading
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Images of fluorescently labelled bones confirmed that such synergism resulted from increases in both endosteal and periosteal bone formation.
3 context sentences(design, population, supporting numbers)
Summary · context
At both levels of loading, there were synergistic effects in cortical bone volume of the proximal tibia and distal ulna between loading and high-dose iPTH (1-34).
Summary · context
The separate and combined effects of intermittent parathyroid hormone (iPTH) (1-34) and mechanical loading were assessed at trabecular and cortical sites of mouse long bones.
Summary · context
Female C57BL/6 mice from 13 to 19 weeks of age were given daily injections of vehicle or PTH (1-34) at low (20 microg/kg/day), medium (40 microg/kg/day) or high (80 microg/kg/day) dose.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1853955607
09AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In mice, synergistic effects of PTH and loading reflected increased periosteal bone formation.
In plain wordsIn mice, PTH with loading increased bone formation on outer bone surfaces.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreasePeriosteal bone formation
Study
mousen: not reported in source
Female C57BL/6 mice with mechanical bone loading
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Images of fluorescently labelled bones confirmed that such synergism resulted from increases in both endosteal and periosteal bone formation.
3 context sentences(design, population, supporting numbers)
Summary · context
At both levels of loading, there were synergistic effects in cortical bone volume of the proximal tibia and distal ulna between loading and high-dose iPTH (1-34).
Summary · context
The separate and combined effects of intermittent parathyroid hormone (iPTH) (1-34) and mechanical loading were assessed at trabecular and cortical sites of mouse long bones.
Summary · context
Female C57BL/6 mice from 13 to 19 weeks of age were given daily injections of vehicle or PTH (1-34) at low (20 microg/kg/day), medium (40 microg/kg/day) or high (80 microg/kg/day) dose.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1853955608
10AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In mice, PTH combined with sufficient loading stimulated woven bone on endosteal and periosteal surfaces of the proximal tibial cortex.
In plain wordsIn mice, PTH with sufficient loading stimulated woven bone on inner and outer surfaces of the upper tibial cortex.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseWoven bone formation with loading
Study
mousen: not reported in source
Female C57BL/6 mice with mechanical bone loading
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
No woven bone was induced by iPTH (1-34) or either level of loading alone, whereas the combination of iPTH (1-34) and the "sufficient" level of loading stimulated woven bone formation on endosteal and periosteal surfaces of the proximal cortex in the tibiae.
2 context sentences(design, population, supporting numbers)
Summary · context
The separate and combined effects of intermittent parathyroid hormone (iPTH) (1-34) and mechanical loading were assessed at trabecular and cortical sites of mouse long bones.
Summary · context
Female C57BL/6 mice from 13 to 19 weeks of age were given daily injections of vehicle or PTH (1-34) at low (20 microg/kg/day), medium (40 microg/kg/day) or high (80 microg/kg/day) dose.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1853955610

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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