In dogs with suspected Addison's disease, cortisol responses were equivalent at 5 microg/kg and 250 microg/dog (16.2+/-7.7 versus 15.9+/-6.3 microg/dL).
In plain wordsIn dogs with suspected Addison's disease, the two cosyntropin doses produced equivalent cortisol responses.
- Peptide
- Cosyntropin
- Outcome
- No significant changeDose equivalence of cortisol response
- Study
dogn = 29
Hospitalized dogs with suspected hypoadrenocorticism- Comparator
- 250 microg/dog cosyntropin
- Outcome group
- Adrenal Function · Endocrine and hormones
Measurements
- 90% CI lower
- 91.2%
- Dose equivalence
- 90% CI upper
- 105.4%
- Dose equivalence
Source sentences
In dogs with suspected Addison's disease, mean (+/-SD) cortisol responses to ACTH in the 5 microg/kg dose (16.2+/-7.7 microg/dL) and 250 microg/dog dose (15.9+/-6.3 microg/dL) were statistically equivalent (90% CI: 91.2-105.4%).
3 context sentences(design, population, supporting numbers)
Eight healthy adult dogs and 29 hospitalized dogs with suspected hypoadrenocorticism.
Dogs received either 5 microg/kg or 250 microg/dog of cosyntropin on day 1 and the alternate dose on day 2.
Dogs with suspected Addison's disease received 2 ACTH stimulation tests, 24 hours apart, using either a dose of 5 microg/kg cosyntropin or 250 microg/dog on the 1st day and the alternate dose on the 2nd day.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.