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Study · Measured the body's own peptide · 2008

2 results

Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons.

Lambert CP, Wright NR, Finck BN, Villareal DT

Journal of applied physiology (Bethesda, Md. : 1985)5 Jun 2008Cited by 173 (Europe PMC)

PMID18535122 (opens in a new tab)PMCIDPMC2519937 (opens in a new tab)DOI10.1152/japplphysiol.00006.2008 (opens in a new tab)PepBankPUB-18535122
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelNon-randomized trialMechanism

    In frail obese older adults, 12 weeks of exercise increased muscle MGF mRNA about 2 fold.

    In plain wordsIn frail obese older adults, exercise raised the body's own MGF gene activity in muscle.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMuscle MGF mRNA after exercise
    Study

    n: not reported in source

    Comparator
    Before intervention
    Outcome group
    Exercise and physical function · Musculoskeletal

    Measurements

    MGF mRNA change
    ≈ 2 fold
    exercise group

    Source sentences

    Summary
    Exercise increased MGF mRNA (approximately 2 fold, P<0.05), but weight loss had no effect.
    1 context sentence
    Summary · context
    We evaluated 12 wk of exercise (aerobic and resistance) or 12 wk of weight loss (approximately 7% reduction) on skeletal muscle mRNAs for toll-like receptor-4 (TLR-4), mechanogrowth factor (MGF), TNF-alpha, and IL-6 in 16 obese (body mass index 38+/-2 kg/m2) older (69+/-1 yr) physically frail individuals.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelNon-randomized trialMechanism

    In frail obese older adults, 12 weeks of weight loss had no effect on muscle MGF mRNA.

    In plain wordsIn frail obese older adults, weight loss did not change the body's own MGF gene activity in muscle.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeMuscle MGF mRNA after diet-induced weight loss
    Study

    n: not reported in source

    Comparator
    Before intervention
    Outcome group
    Exercise and physical function · Musculoskeletal

    Source sentences

    Summary
    Exercise increased MGF mRNA (approximately 2 fold, P<0.05), but weight loss had no effect.
    1 context sentence
    Summary · context
    We evaluated 12 wk of exercise (aerobic and resistance) or 12 wk of weight loss (approximately 7% reduction) on skeletal muscle mRNAs for toll-like receptor-4 (TLR-4), mechanogrowth factor (MGF), TNF-alpha, and IL-6 in 16 obese (body mass index 38+/-2 kg/m2) older (69+/-1 yr) physically frail individuals.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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