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Study · Randomized controlled trial · n = 73 · 2008

8 results

Thymosin alpha 1 provides short-term and long-term benefits in the reimplantation of avulsed teeth: a double-blind randomized control pilot study.

Loo WT, Dou YD, Chou WK, Wang M

The American journal of emergency medicine1 Jun 2008Cited by 10 (Europe PMC)

PMID18534287 (opens in a new tab)DOI10.1016/j.ajem.2007.09.007 (opens in a new tab)PepBankPUB-18534287
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In patients with avulsed teeth, interferon levels were lower with thymosin alpha‑1 than with saline after reimplantation (P < .05).

    In plain wordsIn patients with reimplanted teeth, interferon levels were lower with thymosin alpha‑1 than with saline.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseInterferon level
    Study

    n = 73

    Comparator
    Saline (control)
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The thymosin group demonstrated a lower interferon, tumor necrosis factor alpha and interleukin-6 levels (P < .05) and higher white blood cell levels than the control group (P < .05).
    1 context sentence
    Summary · context
    Seventy-three patients with avulsed teeth were double-blind randomly assigned to a control group and group that used Talpha1.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In patients with avulsed teeth, tumor necrosis factor alpha levels were lower with thymosin alpha‑1 than with saline after reimplantation (P < .05).

    In plain wordsIn patients with reimplanted teeth, tumor necrosis factor alpha levels were lower with thymosin alpha‑1 than with saline.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseTumor necrosis factor alpha level
    Study

    n = 73

    Comparator
    Saline (control)
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The thymosin group demonstrated a lower interferon, tumor necrosis factor alpha and interleukin-6 levels (P < .05) and higher white blood cell levels than the control group (P < .05).
    1 context sentence
    Summary · context
    Seventy-three patients with avulsed teeth were double-blind randomly assigned to a control group and group that used Talpha1.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In patients with avulsed teeth, interleukin-6 levels were lower with thymosin alpha‑1 than with saline after reimplantation (P < .05).

    In plain wordsIn patients with reimplanted teeth, interleukin-6 levels were lower with thymosin alpha‑1 than with saline.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseInterleukin-6 level
    Study

    n = 73

    Comparator
    Saline (control)
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The thymosin group demonstrated a lower interferon, tumor necrosis factor alpha and interleukin-6 levels (P < .05) and higher white blood cell levels than the control group (P < .05).
    1 context sentence
    Summary · context
    Seventy-three patients with avulsed teeth were double-blind randomly assigned to a control group and group that used Talpha1.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In patients with avulsed teeth, white blood cell levels were higher with thymosin alpha‑1 than with saline after reimplantation (P < .05).

    In plain wordsIn patients with reimplanted teeth, white blood cell levels were higher with thymosin alpha‑1 than with saline.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseWhite blood cell level
    Study

    n = 73

    Comparator
    Saline (control)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The thymosin group demonstrated a lower interferon, tumor necrosis factor alpha and interleukin-6 levels (P < .05) and higher white blood cell levels than the control group (P < .05).
    1 context sentence
    Summary · context
    Seventy-three patients with avulsed teeth were double-blind randomly assigned to a control group and group that used Talpha1.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In patients with avulsed teeth, periodontal healing was greater with thymosin alpha‑1 than with saline after reimplantation (P < .05).

    In plain wordsIn patients with reimplanted teeth, gum and ligament healing was greater with thymosin alpha‑1 than with saline.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreasePeriodontal healing
    Study

    n = 73

    Comparator
    Saline (control)
    Outcome group
    Wound healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The thymosin group demonstrated greater periodontal healing (P < .05), less ankylosis (P < .05), less tooth movement, and greater lifetime of the replanted teeth.
    1 context sentence
    Summary · context
    Seventy-three patients with avulsed teeth were double-blind randomly assigned to a control group and group that used Talpha1.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In patients with avulsed teeth, ankylosis was less frequent with thymosin alpha‑1 than with saline after reimplantation (P < .05).

    In plain wordsIn patients with reimplanted teeth, tooth-to-bone fusion was less frequent with thymosin alpha‑1 than with saline.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseAnkylosis
    Study

    n = 73

    Comparator
    Saline (control)
    Outcome group
    Wound healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The thymosin group demonstrated greater periodontal healing (P < .05), less ankylosis (P < .05), less tooth movement, and greater lifetime of the replanted teeth.
    1 context sentence
    Summary · context
    Seventy-three patients with avulsed teeth were double-blind randomly assigned to a control group and group that used Talpha1.
  7. 07HumanRandomized controlled trialEfficacy outcome

    In patients with avulsed teeth, reimplanted teeth moved less with thymosin alpha‑1 than with saline.

    In plain wordsIn patients with reimplanted teeth, the teeth moved less with thymosin alpha‑1 than with saline.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseTooth movement
    Study

    n = 73

    Comparator
    Saline (control)
    Outcome group
    Wound healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The thymosin group demonstrated greater periodontal healing (P < .05), less ankylosis (P < .05), less tooth movement, and greater lifetime of the replanted teeth.
    1 context sentence
    Summary · context
    Seventy-three patients with avulsed teeth were double-blind randomly assigned to a control group and group that used Talpha1.
  8. 08HumanRandomized controlled trialEfficacy outcome

    In patients with avulsed teeth, replanted teeth lasted longer with thymosin alpha‑1 than with saline.

    In plain wordsIn patients with reimplanted teeth, the teeth lasted longer with thymosin alpha‑1 than with saline.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseLifetime of replanted teeth
    Study

    n = 73

    Comparator
    Saline (control)
    Outcome group
    Wound healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The thymosin group demonstrated greater periodontal healing (P < .05), less ankylosis (P < .05), less tooth movement, and greater lifetime of the replanted teeth.
    1 context sentence
    Summary · context
    Seventy-three patients with avulsed teeth were double-blind randomly assigned to a control group and group that used Talpha1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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