In MCT-treated rats, thymulin prevented the characteristic cardiopulmonary disease profile, with some effects also present with zinc-containing vehicle.
In plain wordsIn rats, thymulin prevented the pulmonary hypertension profile, but the zinc-containing vehicle also produced some effects.
- Outcome
- DecreaseCardiopulmonary disease profile
- Study
ratn: not reported in source
Monocrotaline-induced pulmonary hypertension in adult Wistar rats- Outcome group
- Heart function · Respiratory
- Studied dose
- 100 ng/kg daily · subcutaneous · 3 wkAs given in this study (rat).
Source sentences
Thymulin prevented morphological, hemodynamic, and inflammatory cardiopulmonary profile characteristic of MCT-induced PH, whereas part of these effects were also observed in MCT-treated animals injected with the thymulin's vehicle containing zinc.
2 context sentences(design, population, supporting numbers)
Adult Wistar rats received an injection of MCT (60 mg/kg, sc) or an equal volume of saline.
One day after, the animals randomly received during 3 wk an injection of saline, vehicle (zinc plus carboxymethyl cellulose), or thymulin (100 ng/kg, sc, daily).