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Study · Randomized controlled trial · 2008

4 results

Oxytocin shapes the neural circuitry of trust and trust adaptation in humans.

Baumgartner T, Heinrichs M, Vonlanthen A, Fischbacher U, Fehr E

Neuron1 May 2008Cited by 700 (Europe PMC)

PMID18498743 (opens in a new tab)DOI10.1016/j.neuron.2008.04.009 (opens in a new tab)PepBankPUB-18498743
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In human subjects, intranasal oxytocin prevented the fall in trusting behavior after repeated breaches of trust that occurred with placebo.

    In plain wordsIn people who learned their trust was breached, those given oxytocin kept trusting; those given placebo trusted less.

    Peptide
    Oxytocin
    Outcome
    IncreaseTrust adaptation after breach of trust
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    We find that subjects in the oxytocin group show no change in their trusting behavior after they learned that their trust had been breached several times while subjects receiving placebo decrease their trust.
    1 context sentence
    Summary · context
    We examined the neural circuitry of trusting behavior by combining the intranasal, double-blind, administration of oxytocin with fMRI.
  2. 02HumanRandomized controlled trialMechanism

    In human subjects, intranasal oxytocin was associated with reduced amygdala activation during adaptation to breach of trust compared with placebo.

    In plain wordsIn people given oxytocin, brain scans showed less activity in the amygdala than in people given placebo when trust was breached.

    Peptide
    Oxytocin
    Outcome
    DecreaseAmygdala activation during trust adaptation
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    This difference in trust adaptation is associated with a specific reduction in activation in the amygdala, the midbrain regions, and the dorsal striatum in subjects receiving oxytocin, suggesting that neural systems mediating fear processing (amygdala and midbrain regions) and behavioral adaptations…
    1 context sentence
    Summary · context
    We examined the neural circuitry of trusting behavior by combining the intranasal, double-blind, administration of oxytocin with fMRI.
  3. 03HumanRandomized controlled trialMechanism

    In human subjects, intranasal oxytocin was associated with reduced midbrain activation during adaptation to breach of trust compared with placebo.

    In plain wordsIn people given oxytocin, brain scans showed less activity in midbrain regions than in people given placebo when trust was breached.

    Peptide
    Oxytocin
    Outcome
    DecreaseMidbrain activation during trust adaptation
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    This difference in trust adaptation is associated with a specific reduction in activation in the amygdala, the midbrain regions, and the dorsal striatum in subjects receiving oxytocin, suggesting that neural systems mediating fear processing (amygdala and midbrain regions) and behavioral adaptations…
    1 context sentence
    Summary · context
    We examined the neural circuitry of trusting behavior by combining the intranasal, double-blind, administration of oxytocin with fMRI.
  4. 04HumanRandomized controlled trialMechanism

    In human subjects, intranasal oxytocin was associated with reduced dorsal striatum activation during adaptation to breach of trust compared with placebo.

    In plain wordsIn people given oxytocin, brain scans showed less activity in the dorsal striatum than in people given placebo when trust was breached.

    Peptide
    Oxytocin
    Outcome
    DecreaseDorsal striatum activation during trust adaptation
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    This difference in trust adaptation is associated with a specific reduction in activation in the amygdala, the midbrain regions, and the dorsal striatum in subjects receiving oxytocin, suggesting that neural systems mediating fear processing (amygdala and midbrain regions) and behavioral adaptations…
    1 context sentence
    Summary · context
    We examined the neural circuitry of trusting behavior by combining the intranasal, double-blind, administration of oxytocin with fMRI.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials3

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

3 trials · 3 completed · 1 with posted results · source ClinicalTrials.gov (opens in a new tab)

CompletedEarly phase 1NCT03211013

Study of the Effects of Oxytocin on Attentional Bias and Startle in PTSD

Palo Alto Veterans Institute for Researchn = 1710 Jul 2017 to 9 Jun 2021

Posttraumatic Stress Disorder

Trial pageClinicalTrials.govUpdated 10 Jun 2021
CompletedPhase 1Results postedNCT01834261

Brain Dynamics of Oxytocin

Stony Brook Universityn = 51Apr 2013 to May 2015

Brain Dynamics in Healthy Adults

Trial pageClinicalTrials.govUpdated 17 Mar 2017
CompletedPhase not statedNCT01891201

Intrapartum Oxytocin Administration Affects Primitive Neonatal Reflexes

Puerta de Hierro University Hospitaln = 98Mar 2011 to Jun 2013

Bonding · Oxytocin · Breastfeeding · Newborn · Perinatal

Trial pageClinicalTrials.govUpdated 3 Jul 2013

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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